Macro-Aspartate Aminotransferase

Silivontchik, N. N.; Lednik, A. I.; Levchuk, O. P.; Plotnikova, L. I.

doi:10.25298/2616-5546-2021-5-1-25-29

Hepatol and Gastroenterol

2021

DOI: 10.25298/2616-5546-2021-5-1-25-29

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Macro-Aspartate Aminotransferase

N. N. Silivontchik¹,

A. I. Lednik²,

O. P. Levchuk³

et al.

Abstract: Measurement of serum enzyme activity is one of the most common laboratory tests. Increased activity may be caused by abnormal enzymes with a high molecular mass, the so-called macroenzymes. Macroenzymes may be seen in healthy subjects, but can also be related to disease. Macro-aspartate aminotransferase (macro-AST) is a macroenzyme that results from an enzymatic complex consisting of AST linked to serum immunoglobulin (IgA, IgG or both). MacroAST persistence is a rare benign condition. Macro-AST is generally c… Show more

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Cited by 3 publications

References 25 publications

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The Prevalence of Dental Diseases and Features of Hematological Parameters in Cancer Patients

Uspenskaya¹,

Fadeeva²,

Kokobelyan

et al. 2022

Actual Problems in Dentistry

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Subject. Oncological diseases are one of the leading causes of medical losses worldwide, so early and timely diagnosis of oncological diseases remains relevant to this day. Most patients have multiple comorbidities. It is known that all pathological processes occurring in the human body cannot but affect the state of the oral cavity. Therefore, the study of common pathogenetic links in the development of these diseases, including cancer, and the need to optimize the methods of their diagnosis, complex treatment and prevention continue to be relevant. Objectives. To study the features of the dental status and analysis of blood parameters in patients with extraoral pathology. Methodology. To carry out the study, a dental examination was carried out, including an assessment of the condition of the oral mucosa and periodontium, screening by diascopy and APS diagnostics, determination of KPU indices, oral hygiene index OHI-S, PMA, CPITN. All subjects underwent a clinical and biochemical blood test with further research. Results. The study revealed the predominance of certain types of dental diseases in patients with different localization of oncopathology. According to the results of the general and biochemical blood tests, changes were noted that are characteristic of latent iron deficiency and anemia, as well as liver pathology. Conclusion. The study revealed a high intensity of dental caries in cancer patients. A high prevalence of periodontal disease has been noted. Of the dental diseases in cancer patients, hyperplasia of the filiform papillae, geographic tongue, and candidiasis were most often diagnosed. Analysis of blood parameters revealed the presence of a latent iron deficiency and impaired hemoglobin formation. Changes in biochemical parameters of blood, characteristic of the pathological state of liver tissues, were also noted.

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The Prevalence of Dental Diseases and Features of Hematological Parameters in Cancer Patients

Uspenskaya¹,

Fadeeva²,

Kokobelyan

et al. 2022

Actual Problems in Dentistry

View full text Add to dashboard Cite

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Reduction of hepatotoxicity of nimesulide in mechanochemically obtained composition with disodium salt of glycyrrhizic acid

Petrova

Жукова

Evseenko

et al. 2023

Sibirskij nauchnyj medicinskij zhurnal

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Nimesulide (NIM) is a nonsteroid anti-inflammatory drug which acts as a selective cyclooxygenase 2 inhibitor and is widely used for acute pain treatment. In medical practice, a large amount of data has been collected describing the effect of NIM on the body, while a hepatotoxic side effect of the drug has been found. The exact mechanisms of such NIM-induced hepatotoxicity largely remain unknown but likely involve the intermediate reaction of its metabolism. Reduction of the hepatotoxic side effect of NIM is an actual problem for pharmacology. The aim of the present research was to evaluate the hepatotoxicity of the mechanochemically obtained composition of NIM with glycyrrhizic acid disodium salt (Na2GA) compared to pure NIM and a physical mixture of NIM with Na2GA. Material and methods. CD-1 mice were orally administered for 14 days: 1 group – mechanochemical composition NIM/Na2GA (1:10, m/m) at a dose of 1650 mg/kg; 2 group – physical mixture of NIM with Na2GA (1:10, m/m) at a dose of 1650 mg/kg; 3 group – pure NIM at a dose of 600 mg/kg (which pharmacokinetically corresponds to 1650 mg/kg of NIM/Na2GA); 4 group – vehicle (distilled water). The liver damage was assessed using histological studies and enzymatic activity of the alanine aminotransferase and aspartate aminotransferase in blood serum. Results. Histological analysis did not detect any changes in the liver of NIM/Na2GA-treated animals in comparison with a water-treated group. On the opposite, NIM given alone or as a physical mixture with Na2GA induced severe hepatotoxicity in experimental mice. Biochemical analysis of the blood serum revealed that mechanochemical NIM/Na2GA composition significantly reduced activity of the alanine aminotransferase (about 1.5 times) and aspartate aminotransferase (1.3 times) as compared with the pure NIM. Conclusions. The results obtained indicate a high potential for the practical application of the NIM/Na2GA mechanochemical composition.

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Hereditary definiteness of aspartate aminotransferase level in Holstein cattle

Себежко

Konovalova

Korotkevich

et al. 2023

Vestn. Novosib. gos. agrar. univ.

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Farm animals’ growth, development and realization of productive qualities are closely interrelated by enzymatic transformations of amino acids, proteins and other complex nitrogenous compounds. Aspartate aminotransferase (AsT) is involved in the metabolism of amino acids in the cycles of urea, tricarboxylic acids and gluconeogenesis. The level of AsT in the blood depends on many paratypical and genetic factors. The paper presents the results of a biochemical analysis of the AsT content in the blood serum of Holstein bulls aged 12-13 months, who are descendants of 4 breeding bulls. Blood sampling was carried out in animals with a live weight of 330-365 kg, bred in the conditions of a large livestock enterprise located in Western Siberia. The level of AsT in the blood serum of animals was determined by the Reitman-Frenkel colourimetric method using reagents “Transaminase AsT Novo” (manufacturer “Vector-Best” Russia). It was found that the average value of the AsT content in the groups of sons was lower than the generally accepted physiological norm and, for all descendants, was 22.44 ± 1.29 E/l. The reference interval for AsT based on the central 95% percentile with 90% confidence intervals was 12.29 (8.67...15.91) - 34.84(31.2... 38.5) E/l. The descendants of different fathers had different phenotypic variability of the indicator and differed in the level of AST. Thus, the descendants of the bull-producer Brio were characterized by a higher level compared to the sons of the bulls Malstrem and Fabio by 1.69 and 1.8 times, respectively. The revealed differences indicate the hereditary determination of the AsT level in Holstein cattle. The strength of the influence of the father’s factor was 0.18.

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Macro-Aspartate Aminotransferase

Cited by 3 publications

References 25 publications

The Prevalence of Dental Diseases and Features of Hematological Parameters in Cancer Patients

The Prevalence of Dental Diseases and Features of Hematological Parameters in Cancer Patients

Reduction of hepatotoxicity of nimesulide in mechanochemically obtained composition with disodium salt of glycyrrhizic acid

Hereditary definiteness of aspartate aminotransferase level in Holstein cattle

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