Macrolide-resistant Streptococcus pyogenes from Chinese pediatric patients in association with Tn916 transposons family over a 16-year period

Feng, Liqiang; Lin, Hongrui; Ma, Yiming; Yang, Yonghong; Zheng, Yaojie; Fu, Zhou; Yu, Sangjie; Yao, Kaihu; Shen, Xuzhuang

doi:10.1016/j.diagmicrobio.2010.03.014

Cited by 15 publications

(6 citation statements)

References 35 publications

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“…In Chinese pediatric patients, high levels of resistance to erythromycin (94.0%) and clindamycin (96.9%) were detected. These frequencies were significantly higher than those reported in this study, indicating the predominance of the c MLS B phenotype [19]. The MLS B phenotype was also the most prevalent among GAS isolates from pediatric patients in 8 European countries, while MLS B phenotypes as well as a lesser frequency of M phenotype strains were observed in French children [14,20].…”

Section: Discussioncontrasting

confidence: 51%

Throat Carriage Rate and Antimicrobial Resistance of Streptococcus pyogenes In Rural Children in Argentina

Delpech

Sparo

Baldaccini

et al. 2017

J Prev Med Public Health

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ObjectivesThe aim of this study was to determine the prevalence of asymptomatic carriers of group A β-hemolytic streptococci (GAS) in children living in a rural community and to investigate the association between episodes of acute pharyngitis and carrier status.MethodsThroat swabs were collected from September to November 2013 among children 5-13 years of age from a rural community (Maria Ignacia-Vela, Argentina). The phenotypic characterization of isolates was performed by conventional tests. Antimicrobial susceptibility was assayed for penicillin, tetracycline, chloramphenicol, erythromycin, and clindamycin (disk diffusion). The minimum inhibitory concentration was determined for penicillin, cefotaxime, tetracycline, and erythromycin.ResultsThe carriage of β-hemolytic streptococci was detected in 18.1% of participants, with Streptococcus pyogenes in 18 participants followed by S. dysgalactiae ssp. equisimilis in 5. The highest proportion of GAS was found in 8 to 10-year-old children. No significant association between the number of episodes of acute pharyngitis suffered in the last year and the carrier state was detected (p>0.05). Tetracycline resistance (55.5%) and macrolide-resistant phenotypes (11.1%) were observed. Resistance to penicillin, cefotaxime, or chloramphenicol was not expressed in any streptococcal isolate.ConclusionsThe present study demonstrated significant throat carriage of GAS and the presence of group C streptococci (S. dysgalactiae ssp. equisimilis) in an Argentinian rural population. These results point out the need for continuous surveillance of GAS and non-GAS carriage as well as of antimicrobial resistance in highly susceptible populations, such as school-aged rural children. An extended surveillance program including school-aged children from different cities should be considered to estimate the prevalence of GAS carriage in Argentina.

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Section: Discussioncontrasting

confidence: 51%

Throat Carriage Rate and Antimicrobial Resistance of Streptococcus pyogenes In Rural Children in Argentina

Delpech

Sparo

Baldaccini

et al. 2017

J Prev Med Public Health

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“…Interspecific resistance gene exchanges involving enterococci have already been described (Biavasco et al ., ; Vignaroli et al ., ); however, to our knowledge this is the first report of the ability of enterococci from the marine environment to transfer antibiotic resistance to clinical strains. Moreover, whereas the association of tet (M) and erm (B) has already been described (Brenciani et al ., ; Feng et al ., ), this is the first report of co‐transfer of tet (L) and erm (B). These data highlight a possible different association of TET and ERY resistance genes in environmental compared with clinical strains.…”

Section: Resultsmentioning

confidence: 58%

The marine environment as a reservoir of enterococci carrying resistance and virulence genes strongly associated with clinical strains

Cesare

Pasquaroli

Vignaroli

et al. 2013

Environ Microbiol Rep

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To gain insights into the relationships and the genetic exchange among environmental and clinical enterococci, 59 strains (29 from marine aquaculture sites and 30 from clinical settings) resistant to tetracycline, erythromycin, ampicillin and/or gentamicin were analysed for the antibiotic resistance tet(M), tet(L), tet(O), erm(A), erm(B), mef blaZ, aac(6')-Ie aph(2″)-Ia and virulence gelE, cylB, efaA and esp genes, and for the copper resistance gene tcrB. Antibiotic resistance and virulence genes were detected more frequently in clinical than in environmental enterococci; the opposite was true for copper resistance. Conjugation experiments demonstrated the transfer of antibiotic resistance genes from marine to clinical enterococci in interspecific mating and the uncommon joint transfer of tet(L) and erm(B). Enterobacterial repetitive intergenic consensus polymerase chain reaction typing evidenced a cluster (90% similarity) encompassing strains carrying multiple antibiotic resistance genes from both sets; the others marine isolates exhibited polyclonality and bore tcrB. Our results demonstrate that antibiotic-resistant marine enterococci bear antibiotic resistance genes transferable to humans and suggest that copper resistance, not observed among clinical strains, may be useful for survival in the environment, whereas virulence genes likely confer no advantage to enterococcal populations adapted to a lifestyle outside the host.

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“…An effective prevention program for GAS is greatly needed, especially in the developing world, where antibiotic therapy fails to control the occurrences of RF and rheumatic heart disease as it does in developed countries [2,4,16]. The increasing reports of drug-resistant GAS further underscore the need for GAS vaccine [37][38][39][40]. The hyper-variable M protein is the most prominent and promising GAS antigen [17,18].…”

Section: Discussionmentioning

confidence: 99%

Defense From the Group A Streptococcus by Active and Passive Vaccination With the Streptococcal Hemoprotein Receptor

Huang

Fisher

Nasrawi

et al. 2011

The Journal of Infectious Diseases

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Macrolide-resistant Streptococcus pyogenes from Chinese pediatric patients in association with Tn916 transposons family over a 16-year period

Cited by 15 publications

References 35 publications

Throat Carriage Rate and Antimicrobial Resistance of Streptococcus pyogenes In Rural Children in Argentina

Throat Carriage Rate and Antimicrobial Resistance of Streptococcus pyogenes In Rural Children in Argentina

The marine environment as a reservoir of enterococci carrying resistance and virulence genes strongly associated with clinical strains

Defense From the Group A Streptococcus by Active and Passive Vaccination With the Streptococcal Hemoprotein Receptor

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