Macromolecular systems and bactericidal films based on chitin derivatives and silver nanoparticles

Shirokova, L. N.; Alexandrova, V. A.; Егорова, Елена; Vihoreva, G. A.

doi:10.1134/s000368380904005x

Cited by 15 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Silver nanoparticles (SNPs) provide a thermal, chemical, and photostable reservoir of metal atoms that are uniquely suited to polymer composite formation while remaining available for conversion to the active ionic compound upon exposure to physiological solutions. Several silver containing nanocomposites have been described for use in anti‐infective coatings; silver bromide in pyridinium polymer, 21 silver bromide in amphiphilic graft copolymer, 28 silver nanoparticles in carboxymethylchitin, 29 photoreduced silver in polyvinyl alcohol, 30 and sputtered silver in plasma deposited polymer. 31…”

Section: Introductionmentioning

confidence: 99%

Biocompatible/bioabsorbable silver nanocomposite coatings

Qureshi

Monroe

Lopez

et al. 2011

J of Applied Polymer Sci

View full text Add to dashboard Cite

A novel biomass-mediated method to synthesize cellulose-stabilized silver nanoparticles (SNPs) and incorporate them into biocompatible/bioabsorbable poly-L-lactic acid (PLLA) for producing SNP-PLLA nanocomposite thin films was developed and the antimicrobial efficacy and biocompatibility of the SNP-PLLA films were studied. The formation and coating morphology of SNPs were characterized with UV-visible spectrophotometry and transmission electron microscopy (TEM), and the release rate of silver ion from the SNP-PLLA films was determined by inductively coupled plasma-optical emission spectrometry. Antimicrobial testing of the SNP-PLLA films performed with Staphylococcus aureus and Escherichia coli according to ISO 22196 standards demonstrated that the SNP-PLLA nanocomposite films with a SNP concentration of 700 ppm reduced colonies forming unit (CFU) counts by 99.8 and 99.99%, respectively. Despite the significant antimicrobial activity, the nanocomposite films with the same SNP concentration had little effect on the viability of human HeLa cells. This strategy that has been developed for the synthesis of nanoparticles and the formation of composite films demonstrates promise for reducing perioperative surgical site infections associated with indwelling devices.

show abstract

Section: Introductionmentioning

confidence: 99%

Biocompatible/bioabsorbable silver nanocomposite coatings

Qureshi

Monroe

Lopez

et al. 2011

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…Among the several reported proteoglycans, neoproteoglycans can be categorized as conjugates of protein and glycosaminoglycan, nanoparticles conjugated-glycosaminoglycan and polymer conjugated-glycosaminoglycan [281]. Several composite biomaterials synthesized using either natural or synthetic biomaterials have antibacterial components incorporated, such as polyurethane–dextran mats with ciprofloxacin [282], cellulose acetate and shikonin containing poly- l -lactide and poly(lactide- co -glycolide) [283], chitosan–poly( N , N -diethyl-acrylamide) films, scaffolds of poly(ethylene glycol)/chitosan loaded with ciprofloxacin, silver nanoparticles along with chitin-based films [1,284]. Several PEG based composite mixtures have also been reported for wound healing purposes, such as heparin functionalized PEG [285], a combination of proteins with PEG [286] and gelatin-PEG [287].…”

Section: Biomaterials and Nanobiomaterials Used For Several Scaffomentioning

confidence: 99%

Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review

Chaudhari

Vig

Baganizi

et al. 2016

IJMS

466

288

View full text Add to dashboard Cite

Over centuries, the field of regenerative skin tissue engineering has had several advancements to facilitate faster wound healing and thereby restoration of skin. Skin tissue regeneration is mainly based on the use of suitable scaffold matrices. There are several scaffold types, such as porous, fibrous, microsphere, hydrogel, composite and acellular, etc., with discrete advantages and disadvantages. These scaffolds are either made up of highly biocompatible natural biomaterials, such as collagen, chitosan, etc., or synthetic materials, such as polycaprolactone (PCL), and poly-ethylene-glycol (PEG), etc. Composite scaffolds, which are a combination of natural or synthetic biomaterials, are highly biocompatible with improved tensile strength for effective skin tissue regeneration. Appropriate knowledge of the properties, advantages and disadvantages of various biomaterials and scaffolds will accelerate the production of suitable scaffolds for skin tissue regeneration applications. At the same time, emphasis on some of the leading challenges in the field of skin tissue engineering, such as cell interaction with scaffolds, faster cellular proliferation/differentiation, and vascularization of engineered tissues, is inevitable. In this review, we discuss various types of scaffolding approaches and biomaterials used in the field of skin tissue engineering and more importantly their future prospects in skin tissue regeneration efforts.

show abstract

“…The use of cytotoxic drugs, those that inhibit the growth of or kill cells, to treat cancer is referred to as antineoplastic drug therapy or, more commonly, as chemotherapy. The problem of cancer chemotherapy is the severe toxic side effects of anticancer drugs on healthy tissues .…”

Section: Applications Of Cmc and Cmcs Npsmentioning

confidence: 99%

Versatile carboxymethyl chitin and chitosan nanomaterials: a review

Narayanan

Jayakumar

Chennazhi

2014

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Biocompatibility, biodegradability, and low cost of chitin and chitosan have drawn immense attention in many fields including medicine, bioinspired material science, pharmaceuticals, and agriculture. Their handling and processing are difficult owing to its insolubility in neutral aqueous solution or organic solvents. One of the methods used to improve the solubility characteristics of chitin and chitosan is chemical modification. Introducing a carboxymethyl group is the most advantageous method of increasing the solubility of chitosan at neutral and alkaline pH. Carboxymethyl chitin (CMC) and carboxymethyl chitosan (CMCS) are water soluble derivatives formed by introducing CH₂COOH function into the polymer which endows it with better biological properties. The functional group makes CMC/CMCS nanoparticles (NPs) efficient vehicles for the delivery of DNA, proteins, and drugs. This review provides an overview of the characteristics of CMC/CMCS NPs as well as fulfills the task of describing and discussing its important roles primarily in cancer nanomedicine detailing the targeted drug delivery aspect. The application of these NPs in imaging, agriculture, and textiles has also been highlighted. The review also elaborates the advantages of using the CMC and CMCS NPs for drug and gene delivery.

show abstract

Macromolecular systems and bactericidal films based on chitin derivatives and silver nanoparticles

Cited by 15 publications

References 3 publications

Biocompatible/bioabsorbable silver nanocomposite coatings

Biocompatible/bioabsorbable silver nanocomposite coatings

Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review

Versatile carboxymethyl chitin and chitosan nanomaterials: a review

Contact Info

Product

Resources

About