Macrophage Colony‐Stimulating Factor Levels in Amniotic Fluid Before and After the Onset of Labor Do Not Differ in Normal Pregnancies

Hayashi, Masatoshi; Hoshimoto, Kazunori; Komine, Fumiko; Ohkura, Takeyoshi; Inaba, Noriyuki

doi:10.1111/j.1600-0897.2004.00164.x

Cited by 4 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…38,39 Moreover, in term parturition, Hayashi et al revealed that elevated levels of M-CSF in AF were not associated with the onset of labor in term pregnancy and labor, which result in subsequent delivery. 40 However, to date, there has been a paucity of data regarding the altered levels of M-CSF in the CVF in PPROM pregnancies complicated by MIAC/IAI and SPTB. In the context of preterm labor and premature cervical dilation, our previous studies have shown that elevated CVF levels of M-CSF are independently associated with MIAC in women presenting with preterm labor or SPTB at <32 weeks in cases with premature cervical dilation.…”

Section: Discussionmentioning

confidence: 99%

Complement Activation Fragments in Cervicovaginal Fluid Are Associated with Intra-Amniotic Infection/Inflammation and Spontaneous Preterm Birth in Women with Preterm Premature Rupture of Membranes

et al. 2021

View full text Add to dashboard Cite

Objective: We sought to determine whether the levels of complement and other inflammatory and angiogenic mediators in cervicovaginal fluid (CVF) are independently associated with intra-amniotic infection and/or inflammation (IAI) and imminent spontaneous preterm birth (SPTB, ≤48 hours of sampling) in women with preterm premature rupture of membranes (PPROM). Study design: This was a retrospective study consisting of 85 singleton pregnant women with PPROM at 20+0 to 33+6 weeks. Amniotic fluid (AF) obtained via amniocentesis was cultured and assayed for interleukin-6. CVF samples collected at the time of amniocentesis were assayed for complement C3a, C4a, and C5a, HSP70, M-CSF, M-CSF-R, S100 A8, S100 A9, thrombospondin-2, VEGF, and VEGFR-1 by ELISA. Results: Multivariate logistic regression analyses revealed that elevated CVF concentrations of complement C3a, 4a and 5a were significantly associated with an increased risk of IAI and imminent SPTB, whereas those of M-CSF were associated with IAI, but not imminent SPTB (P=0.063), after adjustment for baseline covariates (e.g., gestational age at sampling). However, univariate and multivariate analyses showed that the CVF concentrations of angiogenic (thrombospondin-2, VEGF, and VEGFR-1) and inflammatory (HSP70, M-CSF-R, S100 A8, and S100 A9) proteins were not associated with either IAI or imminent SPTB. Conclusions: In women with PPROM, elevated CVF concentrations of complement C3a, C4a, and C5a are independently related to an increased risk of IAI and imminent SPTB. These findings suggest that complement activation in CVF is significantly involved in mechanisms underlying preterm birth and in the host response to IAI in the context of PPROM.

show abstract

Section: Discussionmentioning

confidence: 99%

Complement Activation Fragments in Cervicovaginal Fluid Are Associated with Intra-Amniotic Infection/Inflammation and Spontaneous Preterm Birth in Women with Preterm Premature Rupture of Membranes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…We examined whether M‐CSF levels in amniotic fluid were increased during labor compared with those in women who were not in labor. Consequently, there was not any difference between the two groups, showing that M‐CSF levels in amniotic fluid in laboring group were similar to those in non‐laboring group 20 . This implies that it is possible to compare M‐CSF levels in amniotic fluid in term gravidas including women in labor and those not in labor to M‐CSF levels in controls.…”

Section: Discussionmentioning

confidence: 87%

Elevation of Macrophage Colony‐Stimulating Factor in Amniotic Fluid at Late Stage of Normal Pregnancy

Hayashi

Hombo

Shibazaki

et al. 2006

American J Rep Immunol

Self Cite

View full text Add to dashboard Cite

show abstract

“…M-CSF and GM-CSF are highly related to the maintenance of pregnancy and the pathophysiology of preeclampsia. However, M-CSF [25] and GM-CSF [26] in amniotic fl uid may not relate to the onset of term labor. In contrast, amniotic fl uid TNF-may contribute to the onset of term labor and / or term labor leading to subsequent delivery may induce the production and secretion of TNF-into the amniotic cavity.…”

Section: Non-labor Groupmentioning

confidence: 88%

Amniotic Fluid Levels of Tumor Necrosis Factor-α and Soluble Tumor Necrosis Factor Receptor 1 Before and After the Onset of Labor in Normal Pregnancies

Hayashi¹,

Zhu²,

Sagesaka³

et al. 2008

Horm Metab Res

View full text Add to dashboard Cite

Tumor necrosis factor-alpha (TNF-alpha) is present in human placental and uterine cells and promotes the regulation of trophoblast growth and invasion. Tumor necrosis factor receptor 1 (TNF-R1) is a receptor for TNF-alpha, and soluble TNF-R1 (sTNF-R1) is present in amniotic fluid after receptor shedding. We evaluated whether amniotic fluid TNF-alpha and sTNF-R1 levels during labor differed from those before the onset of labor in normal pregnancies. This study enrolled 34 Japanese women experiencing normal pregnancies with single fetuses who had no infection. Of these subjects, 17 went into labor and had subsequent term deliveries (the labor group), and the other 17 underwent cesarean section without labor (the nonlabor group). The average gestational age at entry was 38-39 weeks of gestation. Maternal ages and gestational ages did not differ significantly between the two groups. Amniotic fluid was collected and the TNF-alpha and sTNF-R1 levels were determined by the ELISA method. Each of these levels was compared between the two groups. There was a significant increase in amniotic fluid TNF-alpha levels in the labor group. However, amniotic fluid sTNF-R1 levels did not differ significantly between the two groups. Amniotic fluid TNF-alpha may promote the onset of labor at term and/or term labor contributing to subsequent delivery may induce the production and secretion of TNF-alpha into the amniotic cavity. There was no pregnancy-associated increase in receptor shedding or cell apoptosis at the onset of labor.

show abstract

Macrophage Colony‐Stimulating Factor Levels in Amniotic Fluid Before and After the Onset of Labor Do Not Differ in Normal Pregnancies

Abstract: M-CSF in amniotic fluid may not contribute to the onset of labor in term pregnancy and/or labor resulting in subsequent delivery may not induce the production and secretion of M-CSF into amniotic cavity.

Cited by 4 publications

References 27 publications

Complement Activation Fragments in Cervicovaginal Fluid Are Associated with Intra-Amniotic Infection/Inflammation and Spontaneous Preterm Birth in Women with Preterm Premature Rupture of Membranes

Complement Activation Fragments in Cervicovaginal Fluid Are Associated with Intra-Amniotic Infection/Inflammation and Spontaneous Preterm Birth in Women with Preterm Premature Rupture of Membranes

Elevation of Macrophage Colony‐Stimulating Factor in Amniotic Fluid at Late Stage of Normal Pregnancy

Amniotic Fluid Levels of Tumor Necrosis Factor-α and Soluble Tumor Necrosis Factor Receptor 1 Before and After the Onset of Labor in Normal Pregnancies

Contact Info

Product

Resources

About