Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular Disease

Wysoczynski, Marcin; Kim, Jae; Moore, Joseph B.; Uchida, Shizuka

doi:10.3390/ncrna6030028

Cited by 8 publications

(4 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…lncRNA NEXN-AS1 is involved in the mitigation of atherosclerosis. All these RNAs may be targeted for the development of diagnosis and treatment [ 164 ].…”

Section: Clinical Significance Of Lncrnas In Cardiovascular Diseasesmentioning

confidence: 99%

Clinical Significance of MicroRNAs, Long Non-Coding RNAs, and CircRNAs in Cardiovascular Diseases

Singh

Kim

Choi

et al. 2023

Cells

View full text Add to dashboard Cite

Based on recent research, the non-coding genome is essential for controlling genes and genetic programming during development, as well as for health and cardiovascular diseases (CVDs). The microRNAs (miRNAs), lncRNAs (long ncRNAs), and circRNAs (circular RNAs) with significant regulatory and structural roles make up approximately 99% of the human genome, which does not contain proteins. Non-coding RNAs (ncRNA) have been discovered to be essential novel regulators of cardiovascular risk factors and cellular processes, making them significant prospects for advanced diagnostics and prognosis evaluation. Cases of CVDs are rising due to limitations in the current therapeutic approach; most of the treatment options are based on the coding transcripts that encode proteins. Recently, various investigations have shown the role of nc-RNA in the early diagnosis and treatment of CVDs. Furthermore, the development of novel diagnoses and treatments based on miRNAs, lncRNAs, and circRNAs could be more helpful in the clinical management of patients with CVDs. CVDs are classified into various types of heart diseases, including cardiac hypertrophy (CH), heart failure (HF), rheumatic heart disease (RHD), acute coronary syndrome (ACS), myocardial infarction (MI), atherosclerosis (AS), myocardial fibrosis (MF), arrhythmia (ARR), and pulmonary arterial hypertension (PAH). Here, we discuss the biological and clinical importance of miRNAs, lncRNAs, and circRNAs and their expression profiles and manipulation of non-coding transcripts in CVDs, which will deliver an in-depth knowledge of the role of ncRNAs in CVDs for progressing new clinical diagnosis and treatment.

show abstract

“…lncRNA NEXN-AS1 is involved in the mitigation of atherosclerosis. All these RNAs may be targeted for the development of diagnosis and treatment [ 164 ].…”

Section: Clinical Significance Of Lncrnas In Cardiovascular Diseasesmentioning

confidence: 99%

Clinical Significance of MicroRNAs, Long Non-Coding RNAs, and CircRNAs in Cardiovascular Diseases

Singh

Kim

Choi

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

“…Additionally, miRNAs and long non-coding RNAs (lncRNAs) serve as biomarkers of CVD ( 211 – 213 ). Particularly, lncRNAs regulate macrophage functions and thus play a significant role in CVD pathophysiology ( 214 ). Some studies determined a regulatory relationship between different mRNAs and non-coding RNAs ( 215 , 216 ).…”

Section: Network Medicine Paradigms For Cardiovascular Disease Researchmentioning

confidence: 99%

Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases

Sonawane

Aikawa

2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Cardiovascular diseases (CVD) are diverse disorders affecting the heart and vasculature in millions of people worldwide. Like other fields, CVD research has benefitted from the deluge of multiomics biomedical data. Current CVD research focuses on disease etiologies and mechanisms, identifying disease biomarkers, developing appropriate therapies and drugs, and stratifying patients into correct disease endotypes. Systems biology offers an alternative to traditional reductionist approaches and provides impetus for a comprehensive outlook toward diseases. As a focus area, network medicine specifically aids the translational aspect of in silico research. This review discusses the approach of network medicine and its application to CVD research.

show abstract

“…By controlling the nuclear structure and transcription in the nucleus and regulating mRNA stability, translation, and posttranslational modifications in the cytoplasm, lncRNAs perform different biological functions. Currently, lncRNAs are classified into four major classes according to their functions [ 36 ]: the first class of lncRNAs functions in genomic imprinting, the second class of lncRNAs functions in transcriptional regulation, the third class of lncRNAs functions in posttranscriptional regulation, and the fourth class of lncRNAs functions in translational control.…”

Section: Classification and Function Of Lncrnasmentioning

confidence: 99%

Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus

Huang

2021

International Journal of Endocrinology

View full text Add to dashboard Cite

Diabetes is a chronic inflammatory state, and several studies have shown that the mechanisms of insulin resistance and abnormal islet β-cell function in diabetes are closely related to inflammatory reactions. Inflammation plays a critical role in diabetic complications. Long noncoding RNAs (lncRNAs), a new area of genomic research for gene regulation, have complex biological functions in various aspects of cellular biological activity. Recent studies have shown that lncRNAs are associated with the regulation of inflammatory responses in various ways, including at the epigenetic, transcriptional, and posttranscriptional levels. This paper presents a brief review of studies on the mechanisms of lncRNAs in diabetic inflammation. The purpose of this article is to determine the role of lncRNAs in the process of diabetic inflammation and to provide new strategies for the use of lncRNAs in the treatments for diabetic inflammation.

show abstract

Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular Disease

Cited by 8 publications

References 136 publications

Clinical Significance of MicroRNAs, Long Non-Coding RNAs, and CircRNAs in Cardiovascular Diseases

Clinical Significance of MicroRNAs, Long Non-Coding RNAs, and CircRNAs in Cardiovascular Diseases

Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases

Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus

Contact Info

Product

Resources

About