Macrophage migration inhibition factor is elevated in pregnancy, but not to a greater extent in preeclampsia

Hristoskova, Sashka; Holzgreve, Wolfgang; Zhong, Xiao Yan; Hahn, Sinuhe

doi:10.1007/s00404-005-0109-8

Cited by 20 publications

(8 citation statements)

References 12 publications

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“…This implies that MIF may play an important role in these tissues. Although it has recently been reported that circulatory MIF concentrations are elevated under conditions of preeclampsia [79], we could not confirm this finding in a study with a larger cohort [80]. Although MIF clearly influences the behaviour of T and NK cells in the eye, its role in the placenta may be different and, in this case, may rely more on its ability to promote neovascularisation, which is certainly of importance for efficient placentation.…”

Section: Neutrophil Extracellular Trapscontrasting

confidence: 68%

Disturbances in placental immunology: ready for therapeutic interventions?

Hahn

Gupta

Troeger

et al. 2006

Springer Semin Immun

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Recent studies have provided new insight into aberrations in the immunological interplay between mother and fetus and their potential role in the development of recurrent fetal loss and preeclampsia. The action of anti-phospholipid antibodies in recurrent fetal loss is now proposed to involve the complement system, neutrophil activation and the production of TNFα by immune bystander cells. A clear involvement of the immune system is emerging in preeclampsia, involving mainly the innate arm, especially neutrophils. The activation of peripheral neutrophils by placentally released inflammatory debris triggers the induction of neutrophil extracellular traps (NETs), which may lead to an occlusion of the intervillous space, thereby further promoting a condition of placental hypoxia. It has, hence, been suggested that new therapeutic strategies be developed, including the possible use of TNFα antagonists in cases of recurrent miscarriage. These strategies need to be addressed with caution due to the possible induction of fetal congenital abnormalities.

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Section: Neutrophil Extracellular Trapscontrasting

confidence: 68%

Disturbances in placental immunology: ready for therapeutic interventions?

Hahn

Gupta

Troeger

et al. 2006

Springer Semin Immun

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“…2 There are conflicting data in the literature concerning the regulation of MIF during pregnancy and normal labor 15, 17, 20, 29 but serial measurements of circulating maternal MIF indicate that changes in this cytokine are subtle, and do not mirror the exponential rise of CRH levels. 17,19,20 MIF is well positioned physiologically to influence behavior because it is present in the brain and it has been shown to modulate catecholamine metabolism and neuronal activity in vitro. [30][31][32] We found that women with risk-taking behavior were more likely to manifest high MIF compared to those without this behavioral factor, and (as previously reported for this cohort) 24 risk-taking behavior (seat belt usage) was connected to an increased rate of PTD.…”

Section: Commentmentioning

confidence: 99%

Serum macrophage migration inhibitory factor in the prediction of preterm delivery

Pearce

Garvin

Grove

et al. 2008

American Journal of Obstetrics and Gynecology

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Serum Macrophage Migration Inhibitory Factor in the Prediction of Preterm Delivery.Objective-Macrophage migration inhibitory factor (MIF) is a soluble mediator that helps govern the interaction between cytokines and stress hormones (e.g. cortisol). We determined if maternal MIF levels predicted subsequent preterm delivery (PTD).Study Design-A nested case-control study measuring serum MIF concentration at 9-23 weeks gestation in women who ultimately delivered preterm (n=60) compared to control women who delivered at term (n=122). We also examined the connection of MIF with self-reported psychosocial variables.Results-MIF was elevated in the PTD cases (p=0.0004), and log MIF concentration showed a graded response relationship with likelihood of PTD. High MIF was also associated with maternal risk-taking behavior, which itself was a risk factor for PTD. MIF remained associated independently with PTD after adjusting regression models for several other PTD risk factors (OR, 3.11, 95% CI 1.54-6.30).Conclusion-High serum MIF concentration in early to mid-pregnancy is linked with subsequent preterm delivery.

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“…Macrophage migration inhibitory factor (MIF) is also a known redox protein containing the catalytic thiolprotein CXXC motif [24,25] and studies have shown it functions as such in myocardial ischemia [26], nerve protection [28] and protein chaperoning [25]. During pregnancy, MIF protein can be found in the oviduct, uterus and amniotic fluid and MIF mRNA can be found in ovulated oocytes, zygotes, 2-cell embryos, 8-cell embryos, and blastocysts [17,[29][30][31]. There is also nuclear staining of MIF protein in the extravillious trophoblast and cytotrophoblast and upregulation of MIF on gestation day 10.5 in the placenta [32].…”

Section: The Role Of Mif During Neural Developmentmentioning

confidence: 99%

Macrophage migration inhibitory factor inhibits BMP-4 induced apoptosis

Matluk¹,

Adams²,

Karaczyn³

et al. 2012

ABB

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Non-canonical bone morphogenic protein (BMP) pathway signaling plays a critical role during embryonic neurogenesis, inducing apoptosis and eliminating an excess of neural progenitor cells, in preparation for the population of the neural stem cell niches. Our previous work discovered that non-canonical BMP signaling also induced the expression of the anti-apoptotic cytokine macrophage migration inhibitory factor (MIF). Because there are residual neural progenitors that escape BMP induced apoptosis, we believed the expression of MIF could be used to counter this specific type of developmental apoptosis. In vitro studies using P19 cells and ex vivo studies using E13 neural progenitor from wild type and mif-/-mice revealed that overexpression of mif was able to counteract BMP induced apoptosis, while in contrast ablation of mif resulted in a dramatic increase in apoptosis. Despite this finding, it is interesting to note that mif-/-mice, while presenting an overall increase in apoptosis are viable, ablation of mif expression in zebrafish and frog are embryonic lethal, suggesting a redundant or non-critical role of MIF in the developing mammalian embryo

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Macrophage migration inhibition factor is elevated in pregnancy, but not to a greater extent in preeclampsia

Abstract: Our data suggest that circulatory MIF concentrations are elevated throughout pregnancy, but are not further increased in preeclampsia.

Cited by 20 publications

References 12 publications

Disturbances in placental immunology: ready for therapeutic interventions?

Disturbances in placental immunology: ready for therapeutic interventions?

Serum macrophage migration inhibitory factor in the prediction of preterm delivery

Macrophage migration inhibitory factor inhibits BMP-4 induced apoptosis

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