Macrophage migration inhibitory factor gene: Influence on rheumatoid arthritis susceptibility

Martínez, Alfonso; Orozco, Gisela; Varadé, Jezabel; López, Marta Sánchez; Pascual, Daniel; Balsa, Alejandro; Delgado, Antonio; Concha, Emilio G. de la; Fernández‐Gutiérrez, Benjamín; Martı́n, Javier; Urcelay, Elena

doi:10.1016/j.humimm.2007.06.007

Cited by 48 publications

(36 citation statements)

References 31 publications

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“…Our hypothesis is supported by the discovery that MIF is an upstream regulator of TNF secretion in RA [7]. Moreover, Martinez et al showed that the C allele of the MIF -173G>C polymorphism is associated with early onset RA [15], and it was previously detected that carriers of this allele show higher levels of circulating MIF [16]. Hence, MIF is emerging as an important player on RA onset.…”

Section: Discussionsupporting

confidence: 67%

Serum levels of macrophage migration inhibitory factor are associated with rheumatoid arthritis course

et al. 2011

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Rheumatoid arthritis (RA) is an inflammatory autoimmune disease of unknown etiology. Many cytokines have been found to be associated with RA pathogenesis and among them is macrophage migration inhibitory factor (MIF). The aim of this study was to determine whether MIF serum levels are associated with RA course, clinical activity, and clinical biomarkers of the disease. MIF levels were determined in serum samples of 54 RA patients and 78 healthy subjects (HS) by enzyme-linked immunosorbent assay (ELISA). Disease activity was evaluated using the DAS28 score. Patients were subgrouped according to disease activity and years of evolution of disease. Statistical analysis was carried out by SPSS 10.0 and GraphPad Prism 5 software. RA patients presented increased levels of MIF as compared to HS. MIF levels were raised on early stages of RA and tend to decrease according to years of evolution. Moreover, MIF levels positively correlated with rheumatoid factor in RA patients and with C reactive protein in all individuals studied. Our findings suggest that MIF plays a role in early stages of RA.

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Section: Discussionsupporting

confidence: 67%

Serum levels of macrophage migration inhibitory factor are associated with rheumatoid arthritis course

et al. 2011

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“…It is a potent pro-inflammatory cytokine and has been reported to stimulate TNF and interleukin-6 (IL-6) expression [5]. Altered levels of MIF have been reported in several inflammatory rheumatic diseases, including rheumatoid arthritis (RA) [6], Sjogren's syndrome [7], systemic lupus erythematosus (SLE) [8] and adult onset Still's disease [9]. To date, there have been no published reports of MIF levels in AS.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor

et al. 2009

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Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Mediators such as macrophage migration inhibitory factor (MIF) and interleukin-10 (IL-10) are thought to be involved in several inflammatory conditions, including AS. Proinflammatory cytokines regulate the production of oxidative stress markers, such as nitric oxide (NO) and malondialdehyde (MDA). Although oxidative stress and lipid peroxidation have been reported in AS, the association of AS with commonly known oxidative stress markers and cytokines remains uncertain. We have therefore studied whether serum MIF levels are elevated in patients with AS and whether the levels correlate with oxidative stress markers and disease activity parameters. Twenty-five AS patients and 18 healthy controls participated in this study; subjects with hypertension, diabetes, hyperlipidemia, and obesity were excluded. The levels of acute phase reactants, serum levels of glucose, lipids, MIF, IL-10, NO and MDA were studied. Spinal mobility was assessed by the Bath Ankylosing Spondylitis Metrology Index (BASMI). Patients were also assessed using with the Bath Ankylosing Spondylitis Functional Index and the Bath Ankylosing Spondylitis Disease Activity Index. Age and sex distribution were found to be comparable between AS patients and controls (p > 0.05). Acute phase reactants and MIF levels were significantly higher (p < 0.05) and IL-10 levels were significantly lower (<0.001) in the AS patients than in controls. There was a significant correlation between BASMI and MIF levels in AS patients (r = 0.714, p < 0.001). Based on these results, MIF may be involved in the pathogenesis of the chronic inflammation in AS and, consequently, targeting MIF may be beneficial in preventing complications or in initiating early treatment of the disease.

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“…It was have determined that the MIF -173 C is related to inflammatory sensitivity of polyarthritis whereas it is not in association with the intensity of the disease (17). In another study, they have shown that particularly MIF -173 C allele leads to increased risk of early onset of RA disease (18). MIF gene polymorphism is studied in many different inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

et al. 2016

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Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory (MIF) factor is a regulatory cytokine that inhibits random immune cell migration. MIF gene promoter polymorphisms play a role in the progression of several inflammatory disorders. Aims: To investigate the relationship between the MIF gene -173 G/C single-nucleotide polymorphism (SNP) and AS.

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Macrophage migration inhibitory factor gene: Influence on rheumatoid arthritis susceptibility

Cited by 48 publications

References 31 publications

Serum levels of macrophage migration inhibitory factor are associated with rheumatoid arthritis course

Serum levels of macrophage migration inhibitory factor are associated with rheumatoid arthritis course

Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor

Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

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