Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis

Role of Macrophage Migration Inhibitory Factor in Hepatitis B Virus-Specific Cytotoxic-T-Lymphocyte-Induced Liver Injury

“…Importantly, we have demonstrated that ␣MIF treatment provides partial, but not complete, protection against CTL-induced liver injury, in accordance with a reduction in inflammatory cell recruitment. It has already been published that ␣MIF protects against the induction of inflammatory diseases and the mortality of septic shock (2,3,9,18,20,23). Based on our current observations, we speculate that the protective effect of MIF neutralization for liver injury is mediated as follows.…”

Diagnostic Validity of Serum Macrophage Inhibitor Cytokine and Tissue Polypeptide-Specific Antigen in Pancreatobiliary Diseases

“…It has also shown that it is localized within secretory granules of islet β cells [22]. Several reports have demonstrated the role of MIC-1 in acute pancreatitis [23,24]. …”

Macrophage migration inhibitory factor: molecular, cellular and genetic aspects of a key neuroendocrine molecule

“…The presence of raised MIF protein concentrations within the serum, plasma or tissue in several diseases of an endocrine or chronic inflammatory basis (Niino et al 2000, Yabunaka et al 2000, de Jong et al 2001, Matsumoto & Kanmatsuse 2001, Murakami et al 2001, Morand et al 2002, Sakai et al 2003, suggests a role for MIF in pathogenesis. Alternatively, increased expression of MIF in these sites could be consequential, rather than causative.…”