Macrophage regulation &amp; function in helminth infection

Lechner, Antonie; Bohnacker, Sina; Bieren, Julia Esser‐von

doi:10.1016/j.smim.2021.101526

Cited by 33 publications

(24 citation statements)

References 175 publications

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“…Helminths promote distinct phenotypes and functions in macrophages, reducing or preventing host immunopathology by inducing regulatory cell populations or diverting proinflammatory effector cells (Rolot and Dewals, 2018). This helminth-induced immunomodulation of macrophage polarization can be channeled toward developing new therapeutic approaches to treat immunoinflammatory diseases (Lechner et al, 2021;Steinfelder et al, 2016). In this study, we confirmed that M1 populations in PBMCs and the synovium of joints of CIA model mice were positively correlated with macrophage-derived OC differentiation (Figures 2A-2G).…”

Section: Treatment With Mes Suppresses the Inflammatory Responses Of ...supporting

confidence: 70%

Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization

Cheng

Zhuang

et al. 2022

iScience

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Section: Treatment With Mes Suppresses the Inflammatory Responses Of ...supporting

confidence: 70%

Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization

Cheng

Zhuang

et al. 2022

iScience

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“…Macrophages dominate the immune responses to helminths. Due to their spectra of functional phenotypes, macrophages play a central and pleiotropic role in the host response to infection with helminths (reviewed by Cortes-Selva and Fairfax, 2021; Lechner et al ., 2021). It has been recently proposed that the functional roles of macrophages during helminth infection can be allocated to 3 categories (Coakley and Harris, 2020).…”

Section: Macrophage Activation and Function During Liver Fluke Infectionmentioning

confidence: 99%

Exploring the role of macrophages in determining the pathogenesis of liver fluke infection

Quinteros

O’Brien²,

Donnelly³

2022

Parasitology

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The food-borne trematodes, Opisthorchis viverrini and Clonorchis sinensis, are classified as group 1 biological carcinogens: definitive causes of cancer. By contrast, infections with Fasciola hepatica, also a food-borne trematode of the phylum Platyhelminthes, are not carcinogenic. This review explores the premise that the differential activation of macrophages during infection with these food-borne trematodes is a major determinant of the pathological outcome of infection. Like most helminths, the latter stages of infection with all 3 flukes induce M2 macrophages, a phenotype that mediates the functional repair of tissue damaged by the feeding and migratory activities of the parasites. However, there is a critical difference in how the development of pro-inflammatory M1 macrophages is regulated during infection with these parasites. While the activation of the M1 macrophage phenotype is largely suppressed during the early stages of infection with F. hepatica, M1 macrophages predominate in the bile ducts following infection with O. viverrini and C. sinensis. The anti-microbial factors released by M1 macrophages create an environment conducive to mutagenesis, and hence the initiation of tumour formation. Subsequently, the tissue remodelling processes induced by the M2 macrophages promote the proliferation of mutated cells, and the expansion of cancerous tissue. This review will also explore the interactions between macrophages and parasite-derived signals, and their contributions to the stark differences in the innate immune responses to infection with these parasites.

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“…Similarly, a significant effort is being made on studying the host's response to FBT infections. In this regard, macrophages play an important role in the innate immune response against helminthiases in general, being classically or alternatively activated depending on the https://doi.org/10.1017/S0031182022000877 Published online by Cambridge University Press fluke life-stage (Lechner et al, 2021). In the next paper, Quinteros et al summarise the responses of macrophages to parasite-derived signals with a focus on liver flukes and discuss their importance in host susceptibility to fluke-induced cancer (Quinteros et al, 2022).…”

Section: Molecular-level Understanding Of Fbt-host Interactionsmentioning

confidence: 99%

Section: Molecular-level Understanding Of Fbt–host Interactionsmentioning

confidence: 99%

“…Finally, the impact of FBTs on their hosts cannot be fully understood unless the microbiome is included in the equation and any interactions are analysed as a 3-way communication between the host, the parasite and the host's microbiome (Lechner et al ., 2021). Not only can helminths impact host immunity by modifying its microbiome (Brosschot and Reynolds, 2018) but they can also harbour bacteria that can colonize the human gastrointestinal tract and promote pathogenesis (Sripa et al ., 2017).…”

Section: Molecular-level Understanding Of Fbt–host Interactionsmentioning

confidence: 99%

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Foodborne trematodes: old foes, new kids on the block and research perspectives for control and understanding host–parasite interactions

Robinson

Sotillo

2022

Parasitology

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Foodborne trematodes (FBTs) have a worldwide distribution (with particular prevalence in south-east Asia) and are believed to infect almost 75 million people, with millions more living at risk of infection. Although mortality due to trematodiasis is low, these infections cause considerable morbidity and some species are associated with the development of cancer in hyperendemic regions. Despite this, FBTs are often side-lined in terms of research funding and have been dubbed neglected tropical diseases by the World Health Organisation. Thus, the aim of this special issue was to provide an update of our understanding of FBT infections, to shine a light on current work in the field and to highlight some research priorities for the future. With contributions from leading researchers, many from endemic regions, we review the major FBT species. In doing so we revisit some old foes, uncover emerging infections and discover how outbreaks are being dealt with as a result of new approaches to parasite control. We also report advances in our understanding of the interactions of FBTs with their mammalian hosts and uncover new interplay between trematodes and host microbiome components. We hope that this article collection will stimulate discussion and further research on the FBTs and help raise them from their neglected status.

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Macrophage regulation & function in helminth infection

Cited by 33 publications

References 175 publications

Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization

Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization

Exploring the role of macrophages in determining the pathogenesis of liver fluke infection

Foodborne trematodes: old foes, new kids on the block and research perspectives for control and understanding host–parasite interactions

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