Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance

Yadav, Shivani; Priya, Astik; Borade, Diksha R.; Agrawal-Rajput, Reena

doi:10.1007/s12026-022-09330-8

Cited by 25 publications

(9 citation statements)

References 203 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These embryonic-derived macrophages are long-lived and have a high capacity for self-renewal [ 37 ]. TRMs, ranging from Kupffer cells within the liver to microglia within the central nervous system to Langerhans cells within the skin, and osteoclasts within bone, populate virtually every tissue within the body [ 38 ]. Despite this, we know little about the presence and potential functions of TRMs within the intervertebral disc.…”

Section: Myeloid Lineage Cells and Their Derivativesmentioning

confidence: 99%

Macrophages and Intervertebral Disc Degeneration

Koroth

Buko

Abbott

et al. 2023

IJMS

View full text Add to dashboard Cite

The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individuals. Increasing evidence suggests that IVD degeneration is a disease of the whole joint that is associated with significant inflammation. Moreover, studies show elevated macrophage accumulation within the IVD with increasing levels of disease severity; however, we still need to understand the roles, be they causative or consequential, of macrophages during the degenerative process. In this narrative review, we discuss hallmarks of IVD degeneration, showcase evidence of macrophage involvement during disc degeneration, and explore burgeoning research aimed at understanding the molecular pathways regulating macrophage functions during intervertebral disc degeneration.

show abstract

Section: Myeloid Lineage Cells and Their Derivativesmentioning

confidence: 99%

Macrophages and Intervertebral Disc Degeneration

Koroth

Buko

Abbott

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…In vitro , BMDMs isolated from WT and IL-10 −/− mice showed similar results as MPE macrophages when activated in the M1 or M2 condition, respectively. The functions of macrophages are affected by the surrounding environments and vary with their phenotype transition [ 32 ]. During this study, we further investigated the changes in macrophage function.…”

Section: Discussionmentioning

confidence: 99%

S100A9 Regulated M1/M2 Macrophage Polarization in Interleukin-10-Induced Promotion of Malignant Pleural Effusion

Pei

Dong

et al. 2023

Journal of Immunology Research

View full text Add to dashboard Cite

Interleukin-10 (IL-10) promotes the formation and development of malignant pleural effusion (MPE). Previous studies have elucidated the pathogenesis from the view of the immune-regulation function of CD4+ T-cells. However, the underlying mechanism is still not fully understood. In this study, our results showed that IL-10 deficiency reduced the percentage of macrophages in mouse MPE and regulated M1/M2 polarization in vivo and in vitro. The migration capacity of tumor cells was suppressed, and apoptosis was promoted when tumor cells were cocultured with MPE macrophages in the absence of IL-10. Messenger RNA sequencing of MPE macrophages showed that S100A9 was downregulated in IL-10−/− mice. Bone marrow-derived macrophages obtained from wild-type mice transfected with S100A9-specific small interfering RNAs (siRNAs) also showed less M2 and more M1 polarization than those from the siRNA control group. Furthermore, downregulation of S100A9 using S100A9-specific siRNA suppressed MPE development, decreased macrophages, and modulated macrophage polarization in MPE in vivo. In conclusion, S100A9 plays a vital role in the process of IL-10 deficiency-mediated MPE suppression by regulating M1/M2 polarization, thus influencing the tumor-migration capacity and apoptosis. This could result in clinically applicable strategies to inhibit the formation of MPE by regulating the polarization of MPE macrophages.

show abstract

“…TAMs are typically categorized into two subtypes, known as the classically activated phenotype (M1 or M1-like phenotype) and alternatively activated phenotype (M2 or M2-like phenotype) (12,14,22,23,35,(37)(38)(39). Importantly, these M1 and M2 macrophages represent dynamically interconvertible subpopulations, and their phenotypes can reversibly switch (11,12,40). Consequently, TAMs exhibit a dualistic nature, capable of both inhibiting and promoting tumor development (11).…”

Section: Dual Role Of Tams In Tumor Microenvironment and Their Immune...mentioning

confidence: 99%

Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights

Yi,

Gai,

Chen

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

The tumor microenvironment is a complex ecosystem where various cellular and molecular interactions shape the course of cancer progression. Macrophage colony-stimulating factor (M-CSF) plays a pivotal role in this context. This study delves into the biological properties and functions of M-CSF in regulating tumor-associated macrophages (TAMs) and its role in modulating host immune responses. Through the specific binding to its receptor colony-stimulating factor 1 receptor (CSF-1R), M-CSF orchestrates a cascade of downstream signaling pathways to modulate macrophage activation, polarization, and proliferation. Furthermore, M-CSF extends its influence to other immune cell populations, including dendritic cells. Notably, the heightened expression of M-CSF within the tumor microenvironment is often associated with dismal patient prognoses. Therefore, a comprehensive investigation into the roles of M-CSF in tumor growth advances our comprehension of tumor development mechanisms and unveils promising novel strategies and approaches for cancer treatment.

show abstract

Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance

Cited by 25 publications

References 203 publications

Macrophages and Intervertebral Disc Degeneration

Macrophages and Intervertebral Disc Degeneration

S100A9 Regulated M1/M2 Macrophage Polarization in Interleukin-10-Induced Promotion of Malignant Pleural Effusion

Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights

Contact Info

Product

Resources

About