Macrophage – the Central Link of the Endometrial Tissue Communication System

Украинец, Р. В.; Корнева, Ю. С.; Доросевич, А. Е.

doi:10.18499/2225-7357-2019-8-4-74-80

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…Длительность существования эндометриоидной кисты яичника и невозможность оттока менструальных масс приводит к постепенному увеличению объема кисты, а, следовательно, и к атрофии ткани пораженного яичника, что также способствует развитию бесплодия. Большой интерес представляет собой взаимоотношение сосудистого русла и его клеточного микроокружения (особенно макрофагов/сидерофагов [2]) в ткани эндометриоидной гетеротопии, которое меняется по мере ее существования, что влечет за собой изменение морфологии кисты. Детальное понимание патоморфоза эндометриоидной гетеротопии, несомненно, поможет найти «ахиллесову пяту» в патогенезе данной патологии и разработать схемы патогенетической терапии, тем самым решая проблему эндометриоз-ассоциированного бесплодия.…”

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A place of siderophage in cellular microenvironment of endometrioid ovarian cyst in the course of its evolution

Украинец¹,

Korneva²

2021

HMJ

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Background. The term «endometriosis» implies the existence of viable tissue of ectopic endometrium in different anatomic locations outside the uterine cavity. The etiopathogenesis of this disease still remains a matter of debate, and one of the main issues of morphology of endometriosis is the interrelation of the vascular bed and of its cellular environment, especially macrophages and siderophages. Aim. Was to identify the dynamics of variation of correlation relationships between siderophages and other cell populations within the wall of the endometrioid cyst and the number of vessels. Materials and Methods. Endometrioid ovarian cysts obtained from 57 patients after surgical treatment, were subjected to histologic examination. Preliminarily all the studied endometrioid cysts were categorized to «young», «mature» and «old» on the basis of certain morphological signs. After staining with hematoxylin and eosin, cellular environment and also the number of vessels were counted in 10 fields under x400 magnification. The data obtained were further subjected to statistical analysis. Results. At the stage of a «young» endometrioid cyst siderophages are rare and are represented by single cells that form the following correlations: negative with neutrophils in the uterine epithelium and stroma of the endometrioid lining, and positive – with neutrophils of the underlying fibrous layer. In addition, there is a single positive correlation between siderophages and macrophages in the stroma of the endometrioid lining. A negative correlation was found between the number of vessels and siderophages in the stroma of the endometrioid lining. A marked increase in the number of siderophages is a distinctive sign of «mature» endometrioid cysts, which may be an evidence of emerging disorders of the blood supply to the tissues of the heterotopia. Significant changes occur in the correlations between siderophages and other cell populations that considerably increase in number. A negative correlation is preserved between the number of vessels and siderophages. In comparison with “young” and “mature” endometrioid cysts, siderophages and cell populations of “old” endometrioid cysts lose almost all their correlations. The correlations formed between the number of vessels and the cell populations do not differ much from those in the “mature” endometrioid cyst. Conclusion. Absence of siderophages in the stroma of endometrioid lining is an indicator of its sufficient vascularization. The macrophage cell center has to maintain homeostasis through polarization of endometrium-associated macrophages to macrophages possessing the function of phagocytosis with subsequent elimination of the products of blood supply disorders and with formation of siderophages.

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A place of siderophage in cellular microenvironment of endometrioid ovarian cyst in the course of its evolution

Украинец¹,

Korneva²

2021

HMJ

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Polarization of macrophage cellular center during endometrioid cyst evolution

Украинец

Korneva

2021

SMJ

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Introduction. Macrophages are the center of homeostasis regulation in endometrioid heterotopia tissue. Being one of the most important elements in understanding the pathogenesis of endometriosis, macrophages control the changes in the cooperation of cellular elements.Aim. The aim of the study was to assess the location, nature, and strength of correlation relationships between the macrophages/ siderophages and other cell populations in the endometrioid cysts wall at various stages of their formation.Material and Methods. The study comprised 57 patients with a histologically verified diagnosis of endometrioid ovarian cyst. All the studied endometrioid cysts were divided into “young”, “mature”, and “old” based on the morphological features. The macrophages/siderophages, lymphocytes, neutrophils, and eosinophils were counted in 10 visual fields in the cyst wall after staining with hematoxylin and eosin at ×400 magnification at the different layers of cyst wall.Results. The dynamics of changes in the location, direction, and strength of correlations showed that the functional destruction of macrophage cell center occurred during maturation and aging of the ovarian endometrioid cyst. This process was caused by an insufficient vascularization of endometrioid heterotopia, increasing pressure inside the cyst, and the gradual compaction of underlying fibrous layer, which lead to the atrophy of endometrioid lining and inability of macrophage cell center to maintain homeostasis. These changes caused a complete depletion of macrophage cell center due to macrophage polarization and subsequent formation of siderophages.Conclusion. In the absence of endometrium-associated macrophage pool renewal, endometrioid heterotopia eventually subside due to the destruction of macrophage cell center that controls its homeostasis.

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Chronic endometritis: A protracted discussion

Tolibova

Tral

2023

jour

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Introduction Chronic endometritis is one of the most important factors leading to reduced fertility in women. The protracted discussion about the presence of this nosology in clinical practice for more than 100 years does not allow to establish the true frequency of chronic endometritis in women of reproductive age. At the present stage, due to the unfavorable demographic situation both in the Russian Federation and in many countries, the study of chronic endometritis, as one of the main determinants of the lesions of the morphological and functional state of the endometrium, is relevant.The purpose of the study is to determine the current state of the problem of verification of chronic endometritis in women with infertility, reproductive losses and repeated failure of assisted reproductive technologies (ART).Materials and methods The sources of information were publications from the databases PubMed, Google Scholar, elibrary.ru and Russian medical journals in the field of obstetrics and gynecology, as well as pathological anatomy in the period from 2013 to 2022.Results and discussion An analysis of the literature showed that chronic endometritis is the cause of infertility, miscarriage and ineffective ART protocols and leads to decrease of the regenerative potential and endometrial reserve. Despite the evidence of the negative impact of chronic endometritis on the reproductive function, at the present stage, the discussion regarding diagnostic approaches to this nosology continues. The use of the histological method of research, as the main and available method for diagnosing the state of the endometrium, is not always allow to verify chronic endometritis, which dictates the need of using high technological methods to confirm and clarify the severity of the pathological process.Conclusion A unified algorithm for diagnosing chronic endometritis in patients with infertility, miscarriage, ineffective ART cycles and a qualified approach to the morphological diagnosis of the state of the endometrium, standardization of the diagnosis of chronic endometritis, and competent interpretation of immunohistochemical data make it possible to select a pathogenetically substantiated therapy aimed at the rehabilitation of reproductive function.

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Macrophage – the Central Link of the Endometrial Tissue Communication System

Cited by 3 publications

References 46 publications

A place of siderophage in cellular microenvironment of endometrioid ovarian cyst in the course of its evolution

A place of siderophage in cellular microenvironment of endometrioid ovarian cyst in the course of its evolution

Polarization of macrophage cellular center during endometrioid cyst evolution

Chronic endometritis: A protracted discussion

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