Macrophages and Bone Marrow-Derived Mesenchymal Stem Cells Work in Concert to Promote Fracture Healing: A Brief Review

Zhao, Qing; Liu, Xinran; Yu, Chuanying; Xiao, Yu

doi:10.1089/dna.2021.0869

Cited by 15 publications

(15 citation statements)

References 77 publications

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“…The optimal ratio between the number of seeded bone marrow derived MSCs and the number of added particles was selected, see details in Supporting Information (Figure S2). When BMSCs are cocultured with macrophages or CM obtained by coculturing samples with macrophages, the aggregation and proliferation of stem cells may be significantly proved under the influence of pro-inflammatory cytokines secreted by immune cells . To assess the cytotoxicity of particles, stem cells and particles were cocultured in CM and BM, and then subjected to CCK8 test, live-staining assays, and CLSM observation (Figure a).…”

Section: Resultsmentioning

confidence: 99%

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Lei

et al. 2023

ACS Biomater. Sci. Eng.

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Modulating both inflammation and stem cells by designing an artificial joint material to obtain the continuous prevention and control on aseptic loosening (AL) is a novel strategy. In this paper, graphene/europium-doped calcium polyphosphate (GNPs/ECPP) particles were obtained by ultrasound method and spark plasma sintering (SPS) method. The prepared particles were used to modulate the inflammatory response and further obtain cascade regulation on the proliferation, recruitment, and differentiation of stem cells. The results showed that particles obtained by SPS had a stronger effect on promoting the proliferation and differentiation of stem cells, while by ultrasound method more stem cells were recruited. Besides, the graphene and Eu3+ contained in the particles obtained by SPS method could effectively play a synergistic role on the differentiation of stem cells. In vivo experiment results demonstrated that the composite particles effectively suppress the inflammatory response, recruit stem cells, and prevent AL by inhibiting the secretion of inflammatory factors.

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Section: Resultsmentioning

confidence: 99%

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Lei

et al. 2023

ACS Biomater. Sci. Eng.

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“…The significance of macrophages and inflammatory responses in tissue regeneration has garnered increasing attention in recent years and has been recognized as a potential and promising target for accelerating tissue regeneration [ 93 , 94 ]. This article provides a summary of the present state of research regarding the involvement of macrophages in tendon-bone healing and the promotion of tendon-bone healing by modulating macrophage polarization ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Regulating Macrophages through Immunomodulatory Biomaterials Is a Promising Strategy for Promoting Tendon-Bone Healing

Gao

Wang

Jin

et al. 2022

JFB

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The tendon-to-bone interface is a special structure connecting the tendon and bone and is crucial for mechanical load transfer between dissimilar tissues. After an injury, fibrous scar tissues replace the native tendon-to-bone interface, creating a weak spot that needs to endure extra loading, significantly decreasing the mechanical properties of the motor system. Macrophages play a critical role in tendon-bone healing and can be divided into various phenotypes, according to their inducing stimuli and function. During the early stages of tendon-bone healing, M1 macrophages are predominant, while during the later stages, M2 macrophages replace the M1 macrophages. The two macrophage phenotypes play a significant, yet distinct, role in tendon-bone healing. Growing evidence shows that regulating the macrophage phenotypes is able to promote tendon-bone healing. This review aims to summarize the impact of different macrophages on tendon-bone healing and the current immunomodulatory biomaterials for regulating macrophages, which are used to promote tendon-bone healing. Although macrophages are a promising target for tendon-bone healing, the challenges and limitations of macrophages in tendon-bone healing research are discussed, along with directions for further research.

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“…They could represent a separate subset of pluripotent progenitor cells, or they could reflect just another manner to exert regulatory functions. The bloodborne pluripotent cells likely arise from the bone marrow [BM] compartment, where they are believed to support hematopoiesis [ 89 , 90 ] and also participate in bone fracture healing [ 91 ] but may decline in effectiveness with age [ 92 ]. Interestingly, MSC from the periosteum may also participate in fracture healing [ 93 ].…”

Section: What Is the Role Of Pluripotent Progenitor Cells That Circul...mentioning

confidence: 99%

One of the Primary Functions of Tissue-Resident Pluripotent Pericytes Cells May Be to Regulate Normal Organ Growth and Maturation: Implications for Attempts to Repair Tissues Later in Life

Hart

2022

IJMS

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Adult mesenchymal stem cells were reported more than 30 years ago. Since then, their potential to repair and regenerate damaged or diseased tissues has been studied intensively in both preclinical models and human trials. Most of the need for such tissue repair/regeneration is in older populations, so much of the effort has been performed with autologous cells in older patients. However, success has been difficult to achieve. In the literature, it has been noted that such progenitor cells from younger individuals often behave with more vigorous activity and are functionally enhanced compared to those from older individuals or animals. In addition, cells with the characteristics of mesenchymal stem cells or pluripotent mesenchymal regulatory cells exist in nearly all tissues and organs as pericytes since fetal life. Such evidence raises the possibility that one of the primary roles of these organ-specific cells is to regulate organ growth and maturation, and then subsequently play a role in the maintenance of organ integrity. This review will discuss the evidence to support this concept and the implications of such a concept regarding the use of these progenitor cells for the repair and regeneration of tissues damaged by injury or disease later in life. For the latter, it may be necessary to return the organ-specific progenitor cells to the functional state that contributed to their effectiveness during growth and maturation rather than attempting to use them after alterations imposed during the aging process have been established and their function compromised.

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Macrophages and Bone Marrow-Derived Mesenchymal Stem Cells Work in Concert to Promote Fracture Healing: A Brief Review

Cited by 15 publications

References 77 publications

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Regulating Macrophages through Immunomodulatory Biomaterials Is a Promising Strategy for Promoting Tendon-Bone Healing

One of the Primary Functions of Tissue-Resident Pluripotent Pericytes Cells May Be to Regulate Normal Organ Growth and Maturation: Implications for Attempts to Repair Tissues Later in Life

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