Macroporous Hydrogel Dressing: A Macroporous Hydrogel Dressing with Enhanced Antibacterial and Anti‐Inflammatory Capabilities for Accelerated Wound Healing (Adv. Funct. Mater. 21/2020)

Huang, Wen‐Can; Ying, Rui; Wang, Wei; Guo, Yuna; He, Yongjun; Mo, Xinya; Xue, Changhu; Mao, Xiangzhao

doi:10.1002/adfm.202070132

Cited by 23 publications

(21 citation statements)

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“…Wound infection is one of the main causes of death for injured patients, and the long‐lasting inflammation may lead to further tissue damage and delayed wound healing. [ 3 ] Thus, in the study, the two typical pro‐inflammatory factors, including TNF‐ α and IL‐6, were detected to estimate the effect of the BC/Gel/SeNPs hydrogel in preventing the infection and extenuating the inflammation during wound healing. In line with the observations from H&E staining in Figure 6A, although no significant difference in the expression of TNF‐ α and IL‐6 was found among all the groups on day 14 ( Figure B,C), large amounts of IL‐6 and TNF‐ α were monitored in the Gauze, BC, and BC/Gel groups, on day 7 when little expression of the two cytokines was observed in the BC/Gel/SeNPs group (Figure 7A–C).…”

Section: Resultsmentioning

confidence: 99%

“…[ 1 ] This bacteria‐associated wound infection can hinder the wound healing process, cause immune dysfunction, and even threaten patients’ lives. [ 2,3 ] Thus, appropriate wound management to prevent wound infection and promote wound healing is of prevailing importance. Currently, the most common clinical strategy for protecting against or treating wound infection is to use antiseptic or antibiotic‐loaded antibacterial wound dressings.…”

Section: Introductionmentioning

confidence: 99%

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In Situ Synthesized Selenium Nanoparticles‐Decorated Bacterial Cellulose/Gelatin Hydrogel with Enhanced Antibacterial, Antioxidant, and Anti‐Inflammatory Capabilities for Facilitating Skin Wound Healing

Mao

Wang

Zhang

et al. 2021

Adv Healthcare Materials

205

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Bacterial-associated wound infection and antibiotic resistance have posed a major burden on patients and health care systems. Thus, developing a novel multifunctional antibiotic-free wound dressing that cannot only effectively prevent wound infection, but also facilitate wound healing is urgently desired. Herein, a series of multifunctional nanocomposite hydrogels with remarkable antibacterial, antioxidant, and anti-inflammatory capabilities, based on bacterial cellulose (BC), gelatin (Gel), and selenium nanoparticles (SeNPs), are constructed for wound healing application. The BC/Gel/SeNPs nanocomposite hydrogels exhibit excellent mechanical properties, good swelling ability, flexibility and biodegradability, and favorable biocompatibility, as well as slow and sustainable release profiles of SeNPs. The decoration of SeNPs endows the hydrogels with superior antioxidant and anti-inflammatory capability, and outstanding antibacterial activity against both common bacteria (E. coli and S. aureus) and their multidrug-resistant counterparts. Furthermore, the BC/Gel/SeNPs hydrogels show an excellent skin wound healing performance in a rat full-thickness defect model, as evidenced by the significantly reduced inflammation, and the notably enhanced wound closure, granulation tissue formation, collagen deposition, angiogenesis, and fibroblast activation and differentiation. This study suggests that the developed multifunctional BC/Gel/SeNPs nanocomposite hydrogel holds a great promise as a wound dressing for preventing wound infection and accelerating skin regeneration in clinic.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Situ Synthesized Selenium Nanoparticles‐Decorated Bacterial Cellulose/Gelatin Hydrogel with Enhanced Antibacterial, Antioxidant, and Anti‐Inflammatory Capabilities for Facilitating Skin Wound Healing

Mao

Wang

Zhang

et al. 2021

Adv Healthcare Materials

205

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“…to prevent its release), and when the pH decreases, this interaction is interrupted. With the slow release of Ag + , the hydrogel composite exhibits significant antibacterial activity and accelerated skin regeneration and wound healing [66].…”

Section: Wound Healingmentioning

confidence: 99%

“…They also show excellent capabilities considering the loading and releasing of therapeutic agents and thus are widely used in many biomedical fields. They can be used for wound healing [54][55][56][57][58][59][60][61], antibacterial measures [33,[60][61][62][63][64][65][66][67][68], haemostasis [40,67,[69][70][71][72][73][74][75], bone repair, cartilage repair, bioelectronic devices [68,[76][77][78][79], and drug/growth factors/gene vehicles -69 [80][81][82][83][84][85][86][87], or can act as scaffolds [88,89] for tissue engineering (TE).…”

Section: Introductionmentioning

confidence: 99%

Natural polymer‐based adhesive hydrogel for biomedical applications

Long

Xie

2022

Biosurface and Biotribology

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Hydrogel is a polymer network system that can form a hydrophilic three‐dimensional network structure through different cross‐linking methods. In recent years, hydrogels have received considerable attention due to their good biocompatibility and biodegradability by introducing different cross‐linking mechanisms and functional components. Compared with synthetic hydrogels, natural polymer‐based hydrogels have low biotoxicity, high cell affinity, and great potential for biomedical fields; however, their mechanical properties and tissue adhesion capabilities have been unable to meet clinical requirements. In recent years, many efforts have been made to solve these issues. In this review, the recent progress in the field of natural polymer‐based adhesive hydrogels is highlighted. The authors first introduce the general design principles for the natural polymer‐based adhesive hydrogels being used as excellent tissue adhesives and the challenges associated with their design. Next, their usages in biomedical applications are summarised, such as wound healing, haemostasis, nerve repair, bone tissue repair, cartilage tissue repair, electronic devices, and other tissue repairs. Finally, the potential challenges of natural polymer‐based adhesive hydrogels are presented.

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“…In order to accelerate wound healing, many types of wound dressing have been developed, including gauze, [3,4] film, [5][6][7] sponge and hydrogel. [8][9][10][11] Among them, the hydrogel dressing widely used as one of the raw materials of biomedical materials, especially for wound dressings. In addition, other biomaterials such as alginate can also accelerate wound repair.…”

Section: Introductionmentioning

confidence: 99%

Smart Polycationic Hydrogel Dressing for Dynamic Wound Healing

Dong

Wang

et al. 2022

Small

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It is challenging for traditional wound dressings to adapt to the complex and changeable environment, due to the lack of stable, efficient, and continuous bactericidal activity. They also cannot be satisfied in a multifunctional sensing platform to reconstruct skin sensory functions for human health monitoring. A multifunctional hydrogel dressing is developed here for the treatment of infected wounds and human health monitoring, which is based on alginate and polycation. The in situ polymerization and solvent displacement method are used to functionalize the hydrogel for the improvement of antifreezing, water retention, and environmental adaptability, as well as the adhesion and photothermal property. As a wound dressing, the as‐prepared hydrogel exhibits an excellent antibacterial property against both Escherichia coli and Staphylococcus aureus. In a rat model of full‐thickness wound infection, it significantly accelerates the healing of infected wounds with a high healing rate of 96.49%. In the further multifunctional sensory tests, the hydrogel shows multiple response modes of strain, pressure and temperature, and sensing stability. An idea is provided here to develop a smart hydrogel dressing that can accelerate wound healing and achieve human health monitoring.

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Macroporous Hydrogel Dressing: A Macroporous Hydrogel Dressing with Enhanced Antibacterial and Anti‐Inflammatory Capabilities for Accelerated Wound Healing (Adv. Funct. Mater. 21/2020)

Cited by 23 publications

References 0 publications

In Situ Synthesized Selenium Nanoparticles‐Decorated Bacterial Cellulose/Gelatin Hydrogel with Enhanced Antibacterial, Antioxidant, and Anti‐Inflammatory Capabilities for Facilitating Skin Wound Healing

In Situ Synthesized Selenium Nanoparticles‐Decorated Bacterial Cellulose/Gelatin Hydrogel with Enhanced Antibacterial, Antioxidant, and Anti‐Inflammatory Capabilities for Facilitating Skin Wound Healing

Natural polymer‐based adhesive hydrogel for biomedical applications

Smart Polycationic Hydrogel Dressing for Dynamic Wound Healing

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