Macroporous Polyester—Covered Stent in an Experimental Abdominal Aortic Aneurysm Model

Soula, Philippe; d’Othée, Bertrand Janne; Otal, Philippe; Amin, Chauki; Khoury, Joe; Delisle, Marie–Bernadette; Cérène, A; Joffre, Francis; Rousseau, Hervé

doi:10.1177/152660280100800408

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…Of the 46 selected studies, 30, 15, and 1 reported swine, ovine, and bovine data, respectively. 2 , 10 – 53 In the 1 paper we found describing bovine arterial dimensions, only thoracic aorta measurements were determined to be relevant in this study. We found no study describing aortic arch branch diameters in calves and only 1 study in sheep reporting brachiocephalic trunk diameters.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Large Animal Vascular Dimensions for Intra-Aortic Device Research and Development: A Systematic Review

Georges

Couture

Voisine

2023

Innovations�(Phila)

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Animal studies are often required to evaluate new cardiovascular medical devices before they reach the market. Moreover, first-generation novel devices including aortic endovascular prostheses and circulatory support devices are often larger than later iterations or tested in a limited range of sizes. One of the challenges in evaluating these devices is finding a model that is both accessible and anatomically similar to humans, as there is a paucity of data on vascular dimensions in large animals. We set out to complete a comprehensive review of available reports on vascular dimensions in swine, ovine, and bovine models, with a particular focus on the descending aorta and ilio-femoral arteries. We searched Embase and MEDLINE databases for reports of descending aorta and peripheral vascular dimension in large animal models. Data from swine, ovine, and bovine models were separated by weight into 3 categories: 40 to 60 kg, 61 to 80 kg, and >80 kg. We also incorporate our computed tomography angiography data from 4 large sheep and 9 calves into this review. Swine, sheep, and calf >80 kg may serve as the best models to maximize aortic diameter resemblance to humans. If device implantation can be achieved in aortas of smaller dimensions, care should be taken to ensure access site suitability such as the common femoral artery in these smaller animals.

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Section: Resultsmentioning

confidence: 99%

Assessment of Large Animal Vascular Dimensions for Intra-Aortic Device Research and Development: A Systematic Review

Georges

Couture

Voisine

2023

Innovations�(Phila)

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“…In all others, endothelization was incomplete. Some abdominal and iliac aorta models that have been described underwent endothelization 27 , 28 , while others had formation of neointima 29 , 30 . The different flow characteristics of the thoracic aorta, the interval between surgical intervention and data collection and the format of the aneurysm may be responsible for this variation.…”

Section: Discussionmentioning

confidence: 99%

Thoracic aortic aneurysm. An experimental model in pigs

2021

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Purpose To describe an unpublished experimental model of descending thoracic aortic aneurysm in pigs. Methods Ten Landrace female pigs aged 10 to 12 weeks old and with initial weights from 17 to 25 kg were anesthetized and their descending thoracic aortas exposed by fifth intercostal space left thoracotomy. The thoracic aorta was isolated. A 2-cm wide × 2-cm long patch of ready-made bovine pericardium was sewn onto the left anterolateral side of the aorta. After three weeks’ follow-up, a control aortography was taken, and the animals were euthanized. The segment of thoracic aorta containing the aneurysm and the adherent tissues were explanted en bloc. The specimens were stained for histological examination. Results One hundred percent of the animals survived the procedure, and after sacrifice a patent aneurysm was observed in all of them. There were no defects on the suture lines. Weight gain during follow-up was normal. All specimens exhibited intense adventitial reaction with myofibroblasts. There were no complications related to the thoracotomy. Conclusions The descending thoracic aortic aneurysms induced experimentally appear to be stable, were of easy execution, with null mortality and no influence on the animals’ normal development. Furthermore, they have similar characteristics to those observed in human degenerative aneurysms.

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“…The interposition graft model has been reproduced in dogs, pigs and sheep, with grafts made from crimped woven Dacron [93][94][95][96][97], biomedical grade elastomeric polyurethane [95], autologous jugular vein [98] or gastric serosa patches [99] and segments of glutaraldehyde-treated bovine internal jugular vein [100] to mimic an aneurysm. Another disadvantage is that these aneurysms do not show progressive enlargement thus differing from human AAAs [93][94][95][96][97][98][99][100]. A disadvantage of this model noted in all animals is the presence of moderate to severe fibrous reaction around the artificial aneurysm and in the sac wall.…”

Section: Interposition Graft Modelmentioning

confidence: 99%

“…polyurethane-coated expandable Nitinol stents with/without stainless steel frame [50,95], macroporous polyester-covered stents [98,183], Dacron-wrapped [184] or nylon-covered [185] selfexpanding metallic Gianturco stents, weft-knit Dacron tube with a balloon-expandable stents [94], tantalum-Dacron co-knit stents [96], etc.). polyurethane-coated expandable Nitinol stents with/without stainless steel frame [50,95], macroporous polyester-covered stents [98,183], Dacron-wrapped [184] or nylon-covered [185] selfexpanding metallic Gianturco stents, weft-knit Dacron tube with a balloon-expandable stents [94], tantalum-Dacron co-knit stents [96], etc.).…”

Section: Experimental Models For Endovascular Aaa Repair (Evar)mentioning

confidence: 99%

Experimental Models of Abdominal Aortic Aneurysms: An Overview

Paraskevas

Mikhailidis²,

Perrea³

2008

CPD

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In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons.The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.

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Macroporous Polyester—Covered Stent in an Experimental Abdominal Aortic Aneurysm Model

Abstract: Spontaneous AAA rupture occurred earlier and was not as frequent as previously described for this model. Implantation of the covered stent was feasible, but aneurysm exclusion was not immediate.

Cited by 4 publications

References 19 publications

Assessment of Large Animal Vascular Dimensions for Intra-Aortic Device Research and Development: A Systematic Review

Assessment of Large Animal Vascular Dimensions for Intra-Aortic Device Research and Development: A Systematic Review

Thoracic aortic aneurysm. An experimental model in pigs

Experimental Models of Abdominal Aortic Aneurysms: An Overview

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