Macroscopic and pathological assessment of methylene blue and normal saline on postoperative adhesion formation in a rat cecum model

Abstract

Administrated normal saline individually reduce the adhesion grade near cecum. Conversely, usage of methylene blue 1% may unpredictably increase risk of adhesion formation.

Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions: In vitro and in vivo characterization

“…Adhesions were qualified and quantified using standard scoring systems. The qualitative adhesion scoring (Table 1) was based on extent, type and tenacity of adhesions, as described by [40], [41] with some modifications.…”

“…In addition, adhesions were qualified and quantified in a blinded manner using three scoring systems. Qualitative adhesion scoring was based on extent, type and tenacity of adhesions, as described by with some modifications [40], [41] as displayed in Table 1. Adhesions were assessed according to the quantitative scoring system reported in Egea et al (1995) with some modifications [41], [42] as displayed in Table 2.…”

Effects of saline lavage temperature on peritoneal fibrinolysis and adhesion formation

“…[14] They have demonstrated reduced adhesion scores following 1 ml of saline installation. However, in another experimental rat model of small intestine abrasion with jejunal resection-reanastomosis, intraperitoneal administration of a 6 ml saline has not had any effect on adhesion formation.…”

“…On the other hand, saline is used generally as control in the peritoneal adhesion models of intraabdominal medication. When saline lavage or installation is included into the experimental groups, three different results are observed; beneficial, [10][11][12][13][14] ineffective, [9,[15][16][17][18] or even harmful. [19,20] Another challenge in peritoneal adhesion studies is the use of several different models.…”

Uterotonik Bir Ajandan Fazlası: Oksitosin Postoperatif Adezyonları Önlüyor

“…However, others argued that saline did not decrease adhesion formation [30] . Likewise in our study, adhesion formation was not prevented in the saline-treated group.…”