Macroscopic chirality of strings

Стовбун, С. В.; Zanin, A. M.; Скоблин, А. А.; Михайлов, А. И.; Kostyanovskii, R. G.; Grishin, M. V.; Шуб, Б. Р.

doi:10.1134/s1990793111060261

Cited by 26 publications

(12 citation statements)

References 3 publications

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“…The data obtained using biological material are in good agreement with our earlier experimental and theoreti cal results for chiral low molecular model systems (~200) concerning the kinetics of the formation of supramolecular strings [5,6].…”

Section: On the Supramolecular Mechanism Of Cell-cell Commutationsupporting

confidence: 89%

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On the supramolecular mechanism of cell-cell commutation

Стовбун

Михайлов

Скоблин

et al. 2012

Russ. J. Phys. Chem. B

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Processes of cell commutation via anisometric supramolecular structures (strings) are considered in vitro and using physicochemical models of lipids and trifluoroacetylated amino alcohols. The biological effectiveness of commutation via strings is demonstrated to be higher compared to the diffusion mechanism of transfer of biologically active molecules over distances between objects typical of populations of microor ganisms. A kinetic model of strings is developed, and the rate of signal transmission in such systems is esti mated. It is shown that the condition of the chirality of lipids forming the biomembranes of cells follows from the experimentally observed cell commutation by means of supramolecular anisometric structures.

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Section: On the Supramolecular Mechanism Of Cell-cell Commutationsupporting

confidence: 89%

“…As follows from [5,6] by changing the physicochemi cal parameters of the environment, such as the viscos ity, polarity, and pH, it is easy to control the rate of growth or lifetime of the string, so as to organize dif ferent kinds of biofeedback.…”

Section: On the Supramolecular Mechanism Of Cell-cell Commutationmentioning

confidence: 99%

On the supramolecular mechanism of cell-cell commutation

Стовбун

Михайлов

Скоблин

et al. 2012

Russ. J. Phys. Chem. B

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“…These evaluations indicate that transition from associations to string takes place in solution during the time ~(10 9 -10 7 ) during which an association is assembled from ~(10 1 -10 2 ) molecules (in case of purely diffuse mechanism of assembly; it is easy to show that an association of ~20 molecules meets the macroscopicity criterion [9]) to macroscopically high number thereof (in case of radial assembly in a cooperative fi eld). Hence, in fact associations and strings can form simultaneously during time of ~(10 1 -10 2 ) under experimental conditions.…”

Section: Resultsmentioning

confidence: 96%

Biological fluids as chiral anisometric media

2012

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Molecules of dissolved substance in many homochiral solutions are arranged in linear associations forming chiral strings (with length to diameter proportion of 10(1)-10(5)), which leads to solidification of the solution into anisometric gel. This paper describes the formation of the string system in aqueous solution of amino acid phenylalanine, formation of individual strings, weaving of thin strings into thick ones, successive alteration of the solution chirality sign with transition to new levels of the association organization. It seems that biological media are anisometric fluids containing chiral molecular associations and strings, or anisometric gels.

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“…We demonstrated commutation of mesenchymal cells in vitro through extremely anisometric structures or strings formed from molecular components of the membrane (experimental data [3], Fig. 1).…”

mentioning

confidence: 86%

Chirality and Homochirality of Lipids is Necessary to Form LD-Supramolecular Structures of Cell-Cell Communications

Стовбун

2011

Bull Exp Biol Med

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The processes of cell-cell commutations via anisometric supramolecular structures (strings) in vitro and in physicochemical models of lipids (trifluoroacetylated amino alcohols) were studied. It was shown that biological commutation through strings is more efficient than the diffusion mechanism of transfer of bioactive molecules at distances typical of populations. Strings kinetics was constructed and the signal turnover rate in these systems was evaluated. It was demonstrated that the condition of chirality of lipids forming the cell biomembrane stems from experimentally observed cell commutation through anisometric supramolecular structures.

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Macroscopic chirality of strings

Cited by 26 publications

References 3 publications

On the supramolecular mechanism of cell-cell commutation

On the supramolecular mechanism of cell-cell commutation

Biological fluids as chiral anisometric media

Chirality and Homochirality of Lipids is Necessary to Form LD-Supramolecular Structures of Cell-Cell Communications

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