Macrovascular and microvascular type 2 diabetes complications are interrelated in a mouse model

Cifuentes-Mendiola, Saúl Ernesto; Solís-Suarez, D.L.; Martínez‐Dávalos, A.; García‐Hernández, Ana Lilia

doi:10.1016/j.jdiacomp.2023.108455

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…6 Dysphagia, abdominal pain, diarrhea, and constipation are symptoms that affect the quality of life of diabetic patients. [7][8][9] In addition, several studies have reported macrovascular and microvascular complications, 10 ultrastructural, 11 and morphophysiological changes, 12,13 including dysmotility of the colon in diabetic patients. 14 In experimental models of streptozotocin-induced diabetes, physiologic, morphologic, and quantitative changes, including increased enzyme activity, 4 histomorphometric, 13 and ultrastructural changes, 11 increased proportion of goblet cells and intraepithelial lymphocytes, 15 changes in collagen remodeling, 5,11 and ganglia of the enteric nervous system, 16 have been widely reported.…”

Section: Introductionmentioning

confidence: 99%

extract of Schinus terebinthifolius Raddi intensifies morphological alterations in the colon of diabetic rats

Silva,

Araújo,

Sehaber-Sierakowski

et al. 2024

Rev. Fac. Ciênc. Méd. Sorocaba

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There are several challenges in the treatment of diabetes mellitus. Some of these challenges include the discovery of bioactive compounds with the potential to be adjuncts in the treatment of diabetes mellitus. In this study, the effects of hydroethanolic extract of Schinus terebinthifolius Raddi on physiological, morphological, and quantitative parameters of the colon of diabetic rats were investigated. For this purpose, 16 90-day-old rats were randomly divided into four groups: Normoglycemics (N); normoglycemics treated with (50 mg/kg) the hydroethanolic extract of S. terebinthifolius Raddi (NA); streptozotocin-induced diabetics (D); and streptozotocin-induced diabetics treated with the hydroethanolic extract of S. terebinthifolius Raddi (DA). The diabetic rats had diarrhea, weight loss, increased water and food intake, and high blood glucose levels. In addition, atrophy of the entire intestinal wall and submucosa, hypertrophy of the muscularis mucosae, and changes in the histoarchitecture of the intestinal crypts and enterocytes were observed in groups NA, D, and DA. In addition, changes in collagen remodeling and the ganglia of the enteric nervous system, as well as changes in goblet cells and intraepithelial lymphocytes, were observed only in groups D and DA. Our results show that treatment with S. terebinthifolius Raddi extract does not protect the colon from the damage caused by diabetes, nor does it reverse physiological parameters. Moreover, the treatment caused morphological and quantitative changes in the colon of normoglycemic rats and intensified the damage caused by diabetes.

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Section: Introductionmentioning

confidence: 99%

extract of Schinus terebinthifolius Raddi intensifies morphological alterations in the colon of diabetic rats

Silva,

Araújo,

Sehaber-Sierakowski

et al. 2024

Rev. Fac. Ciênc. Méd. Sorocaba

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Role of Anterior Cingulate Cortex in the exacerbated facial response to mechanical stimuli as a sign of early orofacial neuropathic pain

Andrade-González,

Montes-Ángeles,

Perrusquia-Hernández

et al. 2025

The Journal of Pain

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Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients

Habiba,

Ali,

Ghanem

et al. 2023

Can. J. Physiol. Pharmacol.

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Platelet hyperactivity is one of the key factors implicated in the development and progression of diabetic vascular complications. Activated platelets mediate leukocyte recruitment that further enhances inflammatory responses in vascular wall ultimately resulting in atherosclerotic complications. Since vitamin D insufficiency is highly prevalent in diabetics, we aimed to evaluate the effect of three dosage forms of vitamin D supplementation on lipid profile, NF-κB, platelet aggregation, and platelet calcium content in type 2 diabetic patients. Type 2 diabetic patients were randomized to receive daily (4000 IU/day) or weekly (50 000 IU/week) oral vitamin D3 for 3 months. Another group received a single parenteral dose (300 000 IU) of vitamin D3, whereas the control group received their antidiabetic drug(s) alone. Serum 25(OH)D, total cholesterol, triglycerides, high- and low-density lipoprotein cholesterol, NF-κB, and platelet aggregation were measured at the beginning and 3 months after vitamin D supplementation. Platelet calcium content was evaluated by measuring the fluorescence intensity of Rhod-2-stained platelets by confocal fluorescence microscopy. Results showed that serum 25(OH)D3 levels significantly increased in all vitamin D3-treated groups. However, the mean level for parenteral treated group was significantly lower than oral-treated groups. Oral and parenteral treatment were also able to decrease NF-κB level, platelet aggregation, and platelet calcium content. However, both oral doses of vitamin D3 were superior to the single parenteral dose. In conclusion, restoring normal levels of vitamin D is an important determinant to maintain normal platelet function and reduce inflammation. Nevertheless, further long-term studies are still needed.

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Macrovascular and microvascular type 2 diabetes complications are interrelated in a mouse model

Cited by 5 publications

References 42 publications

extract of Schinus terebinthifolius Raddi intensifies morphological alterations in the colon of diabetic rats

extract of Schinus terebinthifolius Raddi intensifies morphological alterations in the colon of diabetic rats

Role of Anterior Cingulate Cortex in the exacerbated facial response to mechanical stimuli as a sign of early orofacial neuropathic pain

Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients

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