Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma

Hou, Huiyuan; Moghimi, Sasan; Zangwill, Linda M.; Shoji, T.; Ghahari, Elham; Penteado, Rafaella C.; Akagi, Tadamichi; Manalastas, Patricia Isabel C.; Weinreb, Robert N.

doi:10.1016/j.ajo.2018.11.012

Cited by 101 publications

(93 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Evaluations of the macular VD parameters in PPG eyes were not extensive [8,26,29,30]. Our study showed significant macular microvasculature dropout in PPG and early PG eyes, which was supported by Hou et al [30] and Poli et al [29].…”

Section: Discussionsupporting

confidence: 84%

“…Previous studies have reported that the AUROC values for macular VD that ranged from 0.562 to 0.800 for distinguishing between early glaucoma and normal eyes [26,27,30,34]. However, little is known about the diagnostic ability of macular VD in detecting PPG.…”

Section: Discussionmentioning

confidence: 99%

“…A reliable VF test was defined as a VF with a false-positive error of < 15%, a false-negative error of < 15%, and a fixation loss of < 33%. PPG in this study was defined based on the presence of a normal anterior segment on a slitlamp examination, a gonioscopically open angle and glaucomatous optic neuropathy (i.e., optic nerve rim defect (notching or localized thinning), optic disc hemorrhage, and RNFL defect) in the absence of glaucomatous VF abnormalities [7,30]. Glaucomatous VF abnormalities were defined as follows: (1) PSD outside normal limits (P < 0.05) and glaucoma hemifield test outside normal limits; (2) the presence of at least 3 adjacent points within the same hemifield on the pattern deviation probability plot at P < 0.05 with at least 1 point at P < 0.01.…”

Section: Methodsmentioning

confidence: 99%

“…Structural parameters in the macular region such as the ganglion cell complex (GCC) or ganglion cell-inner plexiform layer have been found to be thinner in eyes with pre-perimetric glaucoma (PPG) than in healthy eyes [21][22][23][24][25]. However, only a few studies have focused on macular microcirculation changes in early glaucoma [26][27][28][29][30]. Among these studies, fewer have focused on PPG [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

“…However, only a few studies have focused on macular microcirculation changes in early glaucoma [26][27][28][29][30]. Among these studies, fewer have focused on PPG [28][29][30]. The current study aimed to evaluate macular VD and GCC thickness in eyes with PPG and early perimetric POAG (PG), and to compare the diagnostic abilities of the two parameters in discriminating PPG or early PG eyes from healthy eyes.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma

Wang

Chen

et al. 2020

BMC Ophthalmol

View full text Add to dashboard Cite

Background: To evaluate the macular vessel density (VD) and ganglion cell complex (GCC) thickness in preperimetric (PPG) and early perimetric primary open-angle glaucoma (PG) eyes, and to compare the diagnostic ability of the two measurements to discriminate PPG and early PG eyes from healthy eyes. Methods: Seventy-nine eyes in 72 subjects (31 normal, 26 PPG, and 22 early PG eyes) were included in the consecutive case series. Macular VD and GCC thickness were acquired simultaneously using the 6 × 6 mm 2 highdensity AngioRetina scanning mode. Diagnostic abilities were assessed using the area under the receiver operating characteristic curve (AUROC). Results: Compared to healthy eyes, whole image VD (wiVD) and GCC thickness were significantly lower in PPG and early PG eyes (all P < 0.025). The percent reduction of wiVD was lower than that of GCC thickness in early PG eyes (P < 0.05), while they were similar in PPG eyes (P > 0.05). Regionally, greater VD attenuation and GCC thinning were identified in the perifovea than in the parafovea in both groups (all P < 0.05). Moreover, the percent reduction of VD was less than that of GCC thickness in the perifoveal region in PPG eyes (P < 0.05). The AUROCs for wiVD and GCC thickness were 0.824 and 0.881, respectively, in PPG eyes (P > 0.05), and 0.918 and 0.977, respectively, in early PG eyes (P > 0.05). Conclusions: Macular VD and GCC thickness significantly decreased in PPG and early PG eyes. The perifoveal region appeared to be more vulnerable to macular VD attenuation and GCC thinning in early glaucoma. Our results showed that macular VD measurements may be helpful for detecting and understanding early glaucomatous damage.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma

Wang

Chen

et al. 2020

BMC Ophthalmol

View full text Add to dashboard Cite

show abstract

Rate of Initial Optic Nerve Head Capillary Density Loss and Risk of Visual Field Progression

Tansuebchueasai,

Nishida,

Moghimi

et al. 2024

JAMA Ophthalmol

Self Cite

View full text Add to dashboard Cite

ImportanceRapid initial optic nerve head capillary density loss may be used to assess the risk of glaucoma visual field progression.ObjectiveTo investigate the association between the rate of initial optic nerve head capillary density loss from optical coherence tomography angiography (OCTA) and visual field progression.Design, Setting, ParticipantsThis was a retrospective study of a longitudinal cohort at a glaucoma referral center. A total of 167 eyes (96 with primary open-angle glaucoma and 71 with glaucoma suspect) of 109 patients were monitored for a mean (SD) of 5.7 (1.4) years from January 2015 to December 2022. Data analysis was undertaken in April 2023.Main Outcomes and MeasuresThe rates of initial capillary density and average retinal nerve fiber layer loss were calculated from the first 3 optic nerve head OCTA and OCT scans, respectively, during the initial follow-up (mean [SD], 2.0 [1.0] years). Based on the median rate, eyes were categorized into fast and slow progressor groups. The association between initial capillary density change or retinal nerve fiber layer thinning and visual field progression was evaluated using linear-mixed and time-varying Cox models.ResultsA total of 167 eyes of 109 patients (mean [SD] age, 69.0 [11.1] years; 56 [51.4%] female and 53 [48.6%] male) were assessed. Eighty-three eyes were slow OCTA progressors, while 84 eyes were fast with mean capillary density loss of −0.45% per year and −1.17% per year, respectively (mean difference, −0.72%/year; 95% CI,−0.84 to −0.60; P &lt; .001). Similarly, 83 eyes were slow OCT progressors, while 84 eyes were fast with mean retinal nerve fiber layer thinning of −0.09 μm per year and −0.60 μm per year, respectively (mean difference, −0.51 μm/year; 95% CI,−0.59 to −0.43; P &lt; .001). The fast OCTA and OCT progressors were associated with more rapid visual field loss (mean difference, −0.18 dB/year; 95% CI,−0.30 to −0.06; P = .004 and −0.17 dB/year; 95% CI,−0.29 to −0.06; P = .002, respectively). Fast OCTA progressing eyes were more likely to have visual field progression (hazard ratio, 1.96; 95% CI, 1.04-3.69; P = .04). Seventeen of 52 eyes (32.7%; 95% CI, 32.5-32.8) with fast OCTA and OCT progression developed subsequent visual field likely progression.Conclusion and RelevanceRapid initial optic nerve head capillary density loss from OCTA was associated with a faster rate of visual field progression and a doubling of the risk of developing event progression in this study. These findings may support clinical use of OCTA and OCT optic nerve head measurements for risk assessment of glaucoma progression.

show abstract