Macular Choroidal Thickness in Unilateral Amblyopic Children

Xu, Jun; Zheng, Jingwei; Yu, Shujuan; Sun, Zhang‐Hua; Zheng, Wenhua; Qu, Peng; Chen, Yuanyuan; Chen, Wuhe; Yu, Xinping

doi:10.1167/iovs.14-14439

Cited by 41 publications

(39 citation statements)

References 44 publications

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“…However, other studies, including our study, show that CT of hypermetropic anisometropic amblyopic eyes is thick, even when the difference in the AL or refractive error between amblyopic and fellow eyes is taken into account in the statistical analysis [10, 12, 19]. Furthermore, other investigations have reported changes in the profile of CT [20], in the choroidal structure [21], and in the choroidal blood flow [13] exist in hypermetropic anisometropic amblyopic eyes.…”

Section: Discussionmentioning

confidence: 70%

Effect of amblyopia treatment on choroidal thickness in hypermetropic anisometropic amblyopia using swept-source optical coherence tomography

et al. 2018

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BackgroundRecent studies using optical coherence tomography (OCT) have indicated that choroidal thickness (CT) in the anisometropic amblyopic eye is thicker than that of the fellow and normal control eyes. However, it has not yet been established as to how amblyopia affects the choroid thickening. The purpose of the present study was to investigate the effect of amblyopia treatment on macular CT in eyes with anisometropic amblyopia using swept-source OCT.MethodsThirteen patients (mean age: 6.2 ± 2.4 years) with hypermetropic anisometropic amblyopia were included in this study. Visual acuity (VA), axial length (AL), and CT were measured at the enrollment visit and at the final visit, after at least 6 months of treatment. CT measurements were corrected for magnification error and were automatically analyzed using built-in software and divided into three macular regions (subfoveal choroidal thickness (SFCT), center 1 mm, and center 6 mm). A one-way analysis of covariance using AL as a covariate was performed to determine whether CT in amblyopic eyes changed after amblyopia treatment.ResultsThe average observation period was 22.2 ± 11.0 months. After treatment, VA (logMAR) improvement in the amblyopic eyes was 0.41 ± 0.19 (p < 0.001). SFCT, center 1 mm CT, and center 6 mm CT were significantly thicker in the amblyopic eyes compared with the fellow eyes both before and after treatment (p < 0.05 for all comparisons). There were no significant changes in SFCT, center 1 mm CT, or center 6 mm CT before and after treatment in the amblyopic (p = 0.25, 0.21, and 0.84, respectively) and fellow (p = 0.75, 0.84, and 0.91, respectively) eyes. The correlation between changes in logMAR versus changes in CT after treatment was not significant.ConclusionsAlthough VA in amblyopic eyes was significantly improved after treatment, the choroid thickening of anisometropic amblyopic eyes persisted, and there was no significant change found in the CT after the treatment. Our findings suggest that thickening of the CT in amblyopia is not directly related to visual dysfunction.

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Section: Discussionmentioning

confidence: 70%

Effect of amblyopia treatment on choroidal thickness in hypermetropic anisometropic amblyopia using swept-source optical coherence tomography

et al. 2018

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“…[26][27][28] Nishi and colleagues 26 compared choroidal thickness of the amlyopic eyes with fellow eyes and control eyes in a cohort of 25 patients with hyperopic anisometropic amblyopia and found that subfoveal choroidal thickness was 351.3 AE 54.7 mm in the amblyopic eyes, 283.5 AE 55.2 mm in the fellow eyes, and 282.7 AE 73.3 mm in the control eyes. However, only hyperopic anisometropic amblyopia patients were included in their study.…”

Section: Discussionmentioning

confidence: 99%

Choroidal thickness of children's eyes with anisometropic and strabismic amblyopia

Aygıt¹,

Yılmaz²,

Özkaya³

et al. 2015

Journal of American Association for Pediatric Ophthalmology and

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“…This is the first analysis of amblyopic CC atrophy using SSADA‐OCT noninvasively, and the authors speculate that CC atrophy induced malfunction of the outer retina, resulting in an increase in SFCT. Similarly, Xu J et al found that amblyopic eyes had a greater choroidal thickness at and 2 mm nasal to the fovea compared with the fellow eyes of the children with amblyopia. Moreover, SFCT was moderately and negatively correlated with BCVA, which is inconsistent with the findings of Xu J et al .…”

Section: Discussionmentioning

confidence: 88%

“…Similarly, Xu J et al found that amblyopic eyes had a greater choroidal thickness at and 2 mm nasal to the fovea compared with the fellow eyes of the children with amblyopia. Moreover, SFCT was moderately and negatively correlated with BCVA, which is inconsistent with the findings of Xu J et al .…”

Section: Discussionmentioning

confidence: 88%

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In vivo optical imaging of amblyopia: Digital subtraction autofluorescence and split-spectrum amplitude-decorrelation angiography

et al. 2016

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This is the first report of amblyopia using SSADA-OCT and digital subtraction images of autofluorescence. The mechanistic relationship of a thicker choroid and choroidal capillary atrophy with amblyopia remains to be described. The digital subtraction image confirmed the changes in the microstructure of the amblyopic retina as a supplementary approach to detect the progression of amblyopia. Lasers Surg. Med. 48:660-667, 2016. © 2016 Wiley Periodicals, Inc.

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Macular Choroidal Thickness in Unilateral Amblyopic Children

Cited by 41 publications

References 44 publications

Effect of amblyopia treatment on choroidal thickness in hypermetropic anisometropic amblyopia using swept-source optical coherence tomography

Effect of amblyopia treatment on choroidal thickness in hypermetropic anisometropic amblyopia using swept-source optical coherence tomography

Choroidal thickness of children's eyes with anisometropic and strabismic amblyopia

In vivo optical imaging of amblyopia: Digital subtraction autofluorescence and split-spectrum amplitude-decorrelation angiography

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