Macular Choroidal Thicknesses in Healthy Adults—Relationship With Ocular and Demographic Factors

Tan, Colin S.; Cheong, Kai Xiong

doi:10.1167/iovs.13-13771

Cited by 99 publications

(80 citation statements)

References 35 publications

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“…Since the 2008 advent of EDI OCT for assessing choroidal thickness, a large number of cross‐sectional studies have assessed the choroidal characteristics in normal healthy adults. These studies, examining choroidal thickness in a range of different healthy adult populations (of varying ages and ethnic backgrounds) have commonly noted a high level of between‐subject variability in the thickness of the subfoveal choroid, and have reported mean subfoveal choroidal thickness in their study populations ranging from 203 to 350 μm (Figure ) …”

Section: The Normal Thickness Of the Human Choroidmentioning

confidence: 99%

Choroidal changes in human myopia: insights from optical coherence tomography imaging

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Fuss

Vincent

et al. 2019

Clinical and Experimental Optometry

121

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The choroid is a vascular tissue which plays a range of critical roles in the normal physiology of the eye, such as supplying the outer retina with oxygen and nutrients and the regulation of intraocular pressure. There is also substantial evidence, particularly from animal studies, that the choroid plays an important role in the regulation of eye growth and the development of common refractive errors like myopia. In recent years, advances in optical coherence tomography technology have improved our ability to image and measure the choroid in the human eye. Research using this technology over the past decade has dramatically improved our knowledge of the normal choroid, and its potential role in the regulation of eye growth and refractive error development. This review aims to provide an overview of recent work examining the normal human choroid, its changes with myopia and the possible role of the choroid in the mechanism regulating eye growth. Studies have demonstrated that choroidal thinning accompanies the development and progression of myopia, and have established a close link between eye growth and choroidal thickness changes. Dramatic thinning of the choroid is seen with high myopia, and associations are also observed between choroidal thinning and reduced vision, and the development of retinal pathology associated with high myopia. In the short-term, environmental factors known to be associated with myopia development and more rapid eye growth typically lead to a thinning of the choroid, whereas factors linked to a slowing of eye growth are typically associated with short-term choroidal thickening. Collectively, these findings suggest that the choroid is an important biomarker of eye growth in the human eye, and additional research to better understand the human choroid is likely to further our knowledge of the signals and pathways regulating eye growth, myopia development and progression.

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Section: The Normal Thickness Of the Human Choroidmentioning

confidence: 99%

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Read

Fuss

Vincent

et al. 2019

Clinical and Experimental Optometry

121

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“…For the Spectralis OCT, automated segmentation lines that were originally drawn at the internal limiting membrane and retinal pigment epithelium–Bruch's membrane complex were manually adjusted by trained reading centre-certified graders, as previously described 16 17. The line at the internal limiting membrane was moved to the retinal pigment epithelium–Bruch's membrane complex, while the line at the latter was moved to the chorioscleral junction.…”

Section: Methodsmentioning

confidence: 99%

Comparison of macular choroidal thicknesses from swept source and spectral domain optical coherence tomography

et al. 2015

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“…Significant topographic variations of choroidal and retinal thicknesses at the macula have been reported. 2,3 Some regions of the choroid may be more sensitive to endocrinological changes in acromegaly.…”

Section: Sir Chorio-retinal Thickness Measurements In Patients With mentioning

confidence: 99%

Regarding ‘transient visual loss due to reversible ‘pending’ central retinal artery occlusion in occult giant cell arteritis’

Alwitry

2015

Eye

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Macular Choroidal Thicknesses in Healthy Adults—Relationship With Ocular and Demographic Factors

Abstract: Choroidal thickness varies significantly with spherical equivalent and axial length in all regions of the macula, but exhibits different rates of change among different subfields. The rates of change were greater in the central and inner subfields compared with the outer subfields.

Cited by 99 publications

References 35 publications

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Comparison of macular choroidal thicknesses from swept source and spectral domain optical coherence tomography

Regarding ‘transient visual loss due to reversible ‘pending’ central retinal artery occlusion in occult giant cell arteritis’

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