Macular Choroidal Volume Variations in Highly Myopic Eyes With Myopic Traction Maculopathy and Choroidal Neovascularization

Barteselli, Giulio; Lee, Su Na; El-Emam, Sharif; Hou, Huiyuan; Ma, Feiyan; Chhablani, Jay; Conner, Lindsey; Cheng, Lingyun; Bartsch, Dirk-Uwe; Freeman, William R.

doi:10.1097/iae.0000000000000015

Cited by 29 publications

(18 citation statements)

References 38 publications

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“…This indicates that with increasing axial elongation, the distance between the Bruch membrane and the sclera was markedly decreased (20). Barteselli et al (25) found that the choroidal volume was lower in highly myopic eyes without vitreoretinal or choroidal pathologies than in emmetropic eyes (p<0.001). They also found that choroidal thinning is present in highly myopic eyes compared with emmetropic eyes, and is related to age, AL, and sex.…”

Section: Discussionmentioning

confidence: 97%

Correlation between Choroidal Thickness and Degree of Myopia Assessed with Enhanced Depth Imaging Optical Coherence Tomography

El-Shazly

Farweez

ElSebaay

et al. 2017

European Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 97%

Correlation between Choroidal Thickness and Degree of Myopia Assessed with Enhanced Depth Imaging Optical Coherence Tomography

El-Shazly

Farweez

ElSebaay

et al. 2017

European Journal of Ophthalmology

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“…10,11 In studies using OCT, the choroidal thickness has been reported to be decreased in patients with diabetic retinopathy, rheumatoid arthritis, and myopia. [12][13][14] Xin et al 15 reported that the choroidal thickness was thinner in patients with obstructive sleep apnea syndrome due to intermittent hypoxia. Additionally, Mathew et al 16 reported that the decreased choroidal thickness in patients with sickle cell disease may be due to ischemia and a slower blood flow.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Choroidal Thickness in Children With Iron Deficiency Anemia

Şimşek

Tekin

Bilen

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…In humans, dramatic reductions in ChT and ChBF were observed in high myopia. 12,[23][24][25][41][42][43][44] Additionally, in highly myopic eyes some studies found the decreases in the large choroidal vessels 45 and choriocapillaris vessels, 46,47 as well as thinning of the layer of medium-sized vessels, 48 which might also be correlated with a decrease in ChBP. In our previous study, 49 we found that ChT was decreased when human subjects received a 6-D accommodation stimulus (a factor that might contribute to the development of myopia) compared with zero-accommodation controls.…”

Section: Changes In Cht and Chbp In Guinea Pig Myopia Were Strongly Cmentioning

confidence: 98%

Changes in Choroidal Thickness and Choroidal Blood Perfusion in Guinea Pig Myopia

Zhang

Zhou

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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108

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The purpose of this study was to study changes in choroidal thickness (ChT) and choroidal blood perfusion (ChBP), and the correlation between them, in guinea pig myopia. METHODS. The reliability of optical coherence tomography angiography (OCTA) for measuring ChT and ChBP was verified in guinea pigs, after cervical dislocation (n ¼ 7) or temporal ciliary artery transection (n ¼ 6). Changes in refraction, axial length, ChT, and ChBP were measured during spontaneous myopia (n ¼ 9), monocular form-deprivation myopia (FDM, n ¼ 13), or lens-induced myopia (LIM, n ¼ 14), and after 4 days of recovery from FDM and LIM. RESULTS. The abolition (by cervical dislocation) or reduction (by temporal ciliary artery transection) of ChBP, and of the associated changes in ChT, were verified by OCTA, thus validating the method of measurement. In the spontaneous myopia group, ChT and ChBP were reduced by 25.2% and 31.9%, respectively. In FDM eyes, mean 6 SD ChT and ChBP decreased significantly compared with the untreated fellow eyes (ChT fellow: 76.13 6 9.34 lm versus 64.76 6 11.15 lm for FDM; ChBP fellow: 37.87 6 6.37 3 10 3 versus 30.27 6 6.06 3 10 3 for FDM) and increased after 4 days of recovery (ChT: 77.94 6 12.57 lm; ChBP: 37.41 6 6.11 3 10 3). Effects of LIM were similar to those of FDM. Interocular differences in ChT and ChBP were significantly correlated in each group (FDM: R ¼ 0.71, P < 0.001; LIM: R ¼ 0.53, P < 0.001). CONCLUSIONS. ChT and ChBP were significantly decreased in all three models of guinea pig myopia, and they both increased during recovery. Changes in ChT were positively correlated with changes in ChBP. Therefore, it is possible that the changes of ChT are responsible for the changes of ChBP or vice versa. Keywords: myopia, choroidal thickness, choroidal blood perfusion, guinea pig M yopia is commonly recognized as an ocular disorder that carries significant risks of visually blinding complications. 1,2 In recent decades, the prevalence and severity of myopia have been on the rise, and it is estimated that by 2050 there will be 4.76 billion people with myopia and 0.94 billion with high myopia. 3-6 Meanwhile, the total cost of myopia correction is also increasing, becoming a relatively large economic burden in urbanized countries. 7-9 With the drastic increase in the public health impact, as well as the socioeconomic burden of myopia, many researchers have focused on investigating the mechanisms underlying myopia development. Twenty years ago, in a seminal study, Wallman et al. found that choroidal thickness (ChT) in chicks significantly increased and decreased in response to positive and negative lens-induced defocus, causing hyperopic and myopic refractive shifts, respectively. 10 On removal of the imposed negative lens defocus, the choroid of the now myopic eye thickened, moving the retina forward toward the defocused image plane. Such bidirectional growth regulation has stimulated researchers to study the choroid as a target tissue for myopia control, and ChT has been investigated as a surrogate marker for...

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Macular Choroidal Volume Variations in Highly Myopic Eyes With Myopic Traction Maculopathy and Choroidal Neovascularization

Cited by 29 publications

References 38 publications

Correlation between Choroidal Thickness and Degree of Myopia Assessed with Enhanced Depth Imaging Optical Coherence Tomography

Correlation between Choroidal Thickness and Degree of Myopia Assessed with Enhanced Depth Imaging Optical Coherence Tomography

Evaluation of Choroidal Thickness in Children With Iron Deficiency Anemia

Changes in Choroidal Thickness and Choroidal Blood Perfusion in Guinea Pig Myopia

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