“…While several investigators have utilized automated segmentation for automatic analysis of FA, [10][11][12][13][14][15][16][17][18][19][20][21] MA detection, [22][23][24][25][26][27] extraction of vessels, 15,18,19,28 and foveal avascular zone (FAZ) detection, 14,[29][30][31][32][33] relatively few algorithms have been focused on automated leakage detection or quantification. 10,[34][35][36][37][38][39] Martinez-Costa et al 35 have published a method for detection of macular angiographic leakage due to retinal vein occlusion. The foveal center is manually detected, and then images are aligned automatically.…”