Macular pigment changes after cataract surgery with yellow-tinted intraocular lens implantation

Abstract

Purpose We previously reported that macular pigment optical density (MPOD) levels decreased during a long follow-up period after clear intraocular lens (IOL) implant surgery presumably due to excessive light exposure. We examined changes in MPOD levels in the eyes that received yellow-tinted IOL implant surgery. Subjects and methods This was a prospective, observational study. Fifty-five eyes of 35 patients were studied. MPOD levels were measured with a dual-wavelength autofluorescence technique on day 4; months 1, 3, and 6; and years 1 and 2 postoperatively. The average optical densities at 0°- 2° eccentricities (local MPODs) and total volumes of MPOD (MPOVs) in the area within 1.5° and 9° eccentricities were analyzed. Results The mean local MPOD at baseline (on day 4) was 0.79 at 0°, 0.71 at 0.5°, 0.68 at 0.9°, and 0.32 at 2°. The mean MPOV within 1.5° and 9° at baseline was 2950 and 18,897, respectively. Local MPOD at 0.9° and 2° and MPOVs were slightly decreased at month 1 and increased after that. The increase reached statistical significance in local MPOD at 0.5° and 2° and MPOVs (Tukey–Kramer test). The changes in MPOV within 9° at year 2 [(MPOV on year 2 − MPOV on day 4) / MPOV on day 4] were from −0.21 to 1.18 (mean and standard deviation: 1.14 ± 0.28). The MPOV of 15 eyes increased more than 10% from the initial value, was maintained within 10% in 21 eyes, and deteriorated more than 10% in only 3 eyes. Conclusions Local MPOD and MPOV tended to slightly decrease month 1 postoperatively and gradually increased after that, but the rates of increases in MPOD levels were small. Yellow-tinted IOLs that have a lower transmittance of blue light might be preferable for preserving MPOD levels after surgery.

Lutein and Zeaxanthin Distribution in the Healthy Macula and Its Association with Various Demographic Factors Examined in Pseudophakic Eyes

“…These values could represent a standard for future investigation on MP. MPOD(0.23), MPOD(0.5), MPOD(1), MPOD(2), and MPOV(9) were consistent with our previous studies [ 18 , 31 , 36 , 37 , 39 , 40 ], and this consistency was expected, since the current study was based in part on the same database, although the number of subjects in the present study was larger. The MPOD levels were higher in areas closer to the foveal center.…”

“…Men were 108 (155 eyes), and women were 134 (197 eyes). Some eyes were described in our previous manuscripts and were analyzed in different ways [ 18 , 31 , 36 , 37 , 39 , 40 ].…”

“…Men were 108 (155 eyes), and women were 134 (197 eyes). Some eyes were described in our previous manuscripts and were analyzed in different ways [18,31,36,37,39,40]. All subjects underwent cataract surgery at Seirei Hamamatsu General Hospital between October 2016 and March 2021.…”