Macular Retinal Ganglion Cell Layer Thickness Is Not Reduced in Patients with Obstructive Sleep Apnea

Abstract

Purpose: To evaluate macular ganglion cell layer (GCL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses in patients with obstructive sleep apnea (OSA) syndrome. Methods: 73 OSA patients and 67 age-matched controls were consecutively and prospectively enrolled. All participants underwent at least one reliable standard automated perimetry (SAP) and were imaged with spectral-domain optical coherence tomography (OCT) using two different devices. The OCT parameters were compared between groups, and Pearson correlations between main indices of SAP and OCT parameters were calculated. Results: The pattern standard deviation of SAP was higher in the OSA group (p = 0.001). Mean GCIPL thickness was 82.99 ± 10.30 and 80.78 ± 12.15 µm in the control and OSA groups, respectively (p = 0.25), and GCL thickness was 44.93 ± 11.42 µm in the control group and 48.81 ± 10.85 µm in OSA individuals (p = 0.47). Pearson correlations between the GCIPL-GCL measurements and the main indices of SAP were not significant. Conclusions: Neither GCIPL nor GCL thickness were reduced in OSA subjects compared with healthy individuals. Retinal sensitivity evaluated with SAP was however decreased in OSA patients.

Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome

“… 17 The fact that a tissue using up excessive oxygen such as cornea is quite probable to be consistently hypoxic in OSAS cases, though our study found no significant difference in corneal thickness between the groups. 6 , 18 , 19 However, in a study conducted by Koseoglu et al with 195 participants, corneal thickness decreased in OSAS group compared to the control group. Besides, similarly, they found that CCT was adversely associated with Oxygen Desaturation Index (ODI) values, desaturation rates, and decidedly related with least O 2 immersion values.…”

“…At the point when the AHI is no less than 5 events/h, OSAS is viewed as a clinical substance. 6 It was reported that OSAS was essentially associated with a few neurodegenerative disorders, for example, Alzheimer’s disease, Parkinson disease. 7 - 9 Ophthalmological disorders such as non-arteritic anterior ischemic optic neuropathy (NAION), central serous retinopathy, floppy eyelid syndrome, primary open-angle glaucoma, normal tension glaucoma, and papilledema are in the reports of the patients who are suffering from the effects of OSAS.…”

Peripapillary retina nerve fiber layer thickness and macular ganglion cell layer thickness in patients with obstructive sleep apnea syndrome

“…There are limited studies on ganglion cell thickness in patients with OSAS, which may lead to glaucoma and reduction in RNFL thickness. Ferrandez et al 37 showed that neither GC-IPL nor GCL thickness were reduced in OSAS patients compared with healthy controls. 37 Conversely, Huseyinoglu et al 30 found lower ganglion cell thickness in patients with severe OSAS compared to the control group.…”

“…Ferrandez et al 37 showed that neither GC-IPL nor GCL thickness were reduced in OSAS patients compared with healthy controls. 37 Conversely, Huseyinoglu et al 30 found lower ganglion cell thickness in patients with severe OSAS compared to the control group. In addition, there was a significant negative correlation between AHI and GC thickness.…”

Contributions of the Melanopsin-Expressing Ganglion Cells, Cones, and Rods to the Pupillary Light Response in Obstructive Sleep Apnea

“…7,[19][20][21][80][81][82][83][84] Studies of electrophysiology and RNFL thickness have reported conflicting findings in OSA patients, some showed significant reduction of the RNFL thickness, 9,19,21,71 pattern electroretinogram (PERG), 82,84 and visual evoked potential (VEP), 83,84 while others found no decrease [85][86][87] or alterations of ERG. 83 Our results did not show any reduction of RNFL thickness or VF in the OSA group, in agreement with previous studies by Salzgeber et al, 87 Ferrandez et al, 85,86 and Yu et al, 88 which did not find significant thinning of the RGC layer or macular thickness in OSA patients. Various authors have found affected values of MD and PSD in OSA patients, [89][90][91] and Ferrandez et al 85 have reported an impairment in the VF evaluated by SAP, suggesting dysfunction but not the death of the RGC.…”