Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT

Abstract

Purpose: The aim of this study is too correlate the sensitivity and thickness values of intraretinal layers at macula in healthy eyes and primary open-angle glaucoma (POAG) eyes. Methods: The thickness of different intraretinal segmentations was estimated by means of optical coherence tomography (OCT) Spectralis (Heidelberg, Engineering, Inc., Heidelberg, Germany) with the posterior pole analysis program 8 × 8 in 91 eyes from 91 patients (60 with glaucoma and 31 healthy patients). Macular sensitivity was also measured with an MP-1 microperimeter (Nidek Instruments, Inc Padova, Italy) with a customized, 36-stimulus pattern adjusted to an anatomical correspondence with the OCT grid. Correlations were calculated by using Spearman’s rho and the results were represented in color maps. Results: Significant structure–function correlations were much more frequent in the glaucoma group than in control group. In general terms, associations were positive for inner retinal layers but negative correlations were also found for the inner nuclear layer and outer retinal layer in glaucoma. Conclusions: In general terms, significant structure–function correlations for different intraretinal layers are higher and wider in POAG eyes than in healthy eyes. Inner and outer retinal layers behave differently in terms of the structure–function relationship in POAG as assessed by microperimetry and OCT.

Relationships between mesopic visual sensitivity and macular inner and outer retinal layer thickness in healthy younger, middle‐aged and older adults

“…Furthermore, in primary open‐angle glaucoma, negative correlations were found between retinal sensitivity, as assessed by microperimetry, and the thicknesses of the macular ORLs, but positive correlations were also found for the IRL. These structure–function relationships showed different behaviour depending on the retinal layer considered in agreement with our finding in the older age group (Garcia‐Medina et al, 2021).…”

“…In glaucoma, RGC axons in the inferior hemisphere have been found to be most susceptible to glaucomatous damage (Na et al, 2011; Nakatani et al, 2011), and the inferior outer sector in the macular area was shown to have the greater diagnostic capacity (Na et al, 2011), and inferior inner macular volume to correlate most with visual field mean deviation (Nakatani et al, 2011). Furthermore, in a study in persons with primary open‐angle glaucoma, correlations detected between retinal sensitivity measured by microperimetry and macular GC layer thickness were stronger in the inferior hemisphere (Garcia‐Medina et al, 2021).…”

“…Studies have also shown that mean retinal sensitivity declines with age in healthy eyes (Molina‐Martín et al, 2017; Sabates et al, 2011). While microperimetry and SD–OCT combined has been used to investigate macular structure–function relationships in AMD (Pilotto et al, 2016; Roh et al, 2019; Saßmannshausen et al, 2018; Sayegh et al, 2014; Steinberg et al, 2016; Tepelus et al, 2017; Wu et al, 2014), glaucoma (Garcia‐Medina et al, 2021) and diabetes without retinopathy (Montesano et al, 2021; Orduna‐Hospital et al, 2021), to the best of our knowledge, no prior work has tried to relate macular retinal layer thickness to mesopic visual sensitivity in younger, middle‐aged and older healthy adults.…”

Macular Anatomy Differs in Dyslexic Subjects

“…The thickness value of the other segmentations was also obtained by summing up the thicknesses of the automatically obtained segmentations as follows: ganglion cell complex (RNFL + GCL + IPL), middle retina (INL + OPL + ONL), IPL + INL and OPL + ONL ( Figure 1 a). The thicknesses of OPL and ONL were not considered individually and were summed up, as was performed in previous works regarding autism [ 15 ] and glaucoma [ 16 , 17 , 18 ], because these two layers are hard to be conveniently separated in OCT images due to their similar reflectivity. A three-dimensional video ( Video S1 ) has been made in order to better understand the integration of cross-sectional ( Figure 1 a) and en face OCT images ( Figure 1 b,c).…”

Updates in Clinical and Translational Glaucoma Research

“…Garcia-Medina et al [ 28 ] carried out the work “Macular structure-function relationships of all retinal layers in primary open-angle glaucoma assessed by microperimetry and 8 × 8 posterior pole analysis of OCT”. The authors fully demonstrated that glaucoma eyes displayed more structure–function relationships than healthy eyes.…”