Madelung Disease

Chen, Huanwen; Chen, Huan‐Wu; Chen, Hsiao-Lien; Lai, Chih‐Cheng

doi:10.1016/j.amjms.2016.06.009

Cited by 7 publications

(3 citation statements)

References 2 publications

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“… 3 , 4 Conventional surgery is recommended, especially in heavily vascularized and innervated regions, as well as in violation of patency of the airways and esophagus. 3 , 13 The efficacy of surgical treatment or liposuction is limited. 1 , 14 It is estimated that nearly 63% of patients experience recurrence after surgical resection of adipose tissue, while in the case of liposuction, up to 95% of patients experience recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Madelung’s disease – progressive, excessive, and symmetrical deposition of adipose tissue in the subcutaneous layer: case report and literature review

Szewc

Sitarz

Moroz

et al. 2018

DMSO

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Madelung’s disease is a rare disorder described for the first time in the year 1846 by Brodie. It is characterized by the occurrence of progressive, excessive, and symmetrical deposits of adipose tissue in the subcutaneous layer. Most often, these changes concern the neck, the nape of the neck, arms, and upper back, giving the patients a specific, pseudoathletic appearance. Madelung’s disease is also known as multiple symmetrical lipomatosis, benign symmetrical lipomatosis, and Launois-Bensaude syndrome. The most commonly affected ones are men who drink alcohol in excessive amounts. The fat masses emerging in the course of the disease are painless but can lead to adverse repercussions. Patients may experience dysphagia, dysphonia, difficulty in breathing, and limited mobility of the neck. The reasons for the willingness to take up treatment are also often esthetic reasons. The disease is usually accompanied by numerous metabolic disorders. The etiology of the disease has not been sufficiently explained so far, which creates diagnostic and therapeutic difficulties. Currently used treatment is limited to surgical resection of the resulting lesions or liposuction. Unfortunately, the effectiveness of these activities is limited. Most patients experience recurrence after treatment. This paper discusses the essence of Madelung’s disease, numerous aspects of etiology, the manner of diagnosis, and treatment based on current literature data.

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Section: Discussionmentioning

confidence: 99%

“…4 , 7 The most frequently diagnosed phenotype of the disease is of type 1,with a dominant fat deposit around the neck. 13 , 14 , 16 …”

Section: Introductionmentioning

confidence: 99%

Madelung’s disease – progressive, excessive, and symmetrical deposition of adipose tissue in the subcutaneous layer: case report and literature review

Szewc

Sitarz

Moroz

et al. 2018

DMSO

View full text Add to dashboard Cite

show abstract

“…Основною причиною даної патології є диспластичні порушення в епіфізі променевої кістки постнатального характеру, при нормальному розвитку ліктьової кістки [44]. Частота деформації Маделунга 1:2000-1:4000 населення [45]. Трапляються роботи, в яких доведено існування зв'язку між розвитком деформації Маделунга та генетичною аномалією (аберацією статевих хромосом), фенотиповим проявом якої є затримка статевого дозрівання і менструального циклу [46].…”

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