2018
DOI: 10.3892/mco.2018.1558
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MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation

Abstract: Abstract. Radiotherapy alone, or as an addition to surgery is important for the treatment of head and neck squamous cell carcinoma (HNSCC). In addition to their expression in germ cells, melanoma associated antigens-A (MAGE-A) are only expressed in malignant tissue. Notably, there is a known correlation between MAGE-A9 expression and poor prognosis in HNSCC patients. However, current knowledge regarding the function of MAGE-A9 expression, particularly in the context of irradiation, is limited. MAGE-A9 expressi… Show more

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“…MAGEA9 is considered to be a negative prognostic marker in various cancers [ 24 ]. Our study revealed that miR-143-3p directly targets and inhibits MAGEA9 expression.…”
Section: Discussionmentioning
confidence: 99%
“…MAGEA9 is considered to be a negative prognostic marker in various cancers [ 24 ]. Our study revealed that miR-143-3p directly targets and inhibits MAGEA9 expression.…”
Section: Discussionmentioning
confidence: 99%