Magic Pen?—An Innovative Adjunct for Intraoperative Identification of Parathyroid Glands

Mulder, Michelle B.; Duh, Quan-Yang

doi:10.1001/jamasurg.2023.3257

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…At ASMS 2023 Eberlin and collaborators presented work in which they reported the use of a MasSpec Pen on a Waters Xevo Q‐TOF mass spectrometer using a retrofit heated inlet tube, 221 as was done with the iKnife and the SpiderMass sampling devices 222,223 . Further developments of Eberlins' MasSpec Pen version are on‐going 224–226 . Most of these developments seem to focus on small molecule analyses.…”

Section: Unprecedented Applications Of Evaporation/sublimation‐driven...mentioning

confidence: 99%

Direct sub‐atmospheric pressure ionization mass spectrometry: Evaporation/sublimation‐driven ionization is amazing, fundamentally, and practically

Trimpin,

Inutan,

Pagnotti

et al. 2024

J Mass Spectrom

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This paper covers direct sub‐atmospheric pressure ionization mass spectrometry (MS). The discovery, applications, and mechanistic aspects of novel ionization processes for use in MS that are not based on the high‐energy input from voltage, laser, and/or high temperature but on sublimation/evaporation within a region linking a higher to lower pressure and modulated by heat and collisions, are discussed, including how this new reality has guided a series of discoveries, instrument developments, and commercialization. A research focus, inter alia, is on how best to understand, improve, and use these novel ionization processes, which convert volatile and nonvolatile compounds from solids (sublimation) or liquids (evaporation) into gas‐phase ions for analysis by MS providing reproducible, accurate, sensitive, and prompt results. Our perception on how these unprecedented versus traditional ionization processes/methods relate to each other, how they can be made to coexist on the same mass spectrometer, and an outlook on new and expanded applications (e.g., clinical, portable, fast, safe, and autonomous) is presented, and is based on ST's Opening lecture presentation at the Nordic Mass spectrometry Conference, Geilo, Norway, January 2023. Focus will be on matrix‐assisted ionization (MAI) and solvent‐assisted ionization (SAI) MS covering the period from 2010 to 2023; a potential paradigm shift in the making.

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Section: Unprecedented Applications Of Evaporation/sublimation‐driven...mentioning

confidence: 99%

Direct sub‐atmospheric pressure ionization mass spectrometry: Evaporation/sublimation‐driven ionization is amazing, fundamentally, and practically

Trimpin,

Inutan,

Pagnotti

et al. 2024

J Mass Spectrom

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Primary hyperparathyroidism: from guidelines to outpatient clinic

Palermo,

Tabacco,

Makras

et al. 2024

Rev Endocr Metab Disord

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Magic Pen?—An Innovative Adjunct for Intraoperative Identification of Parathyroid Glands

Abstract: King ME, Zhang J, Lin JQ, et al. Rapid diagnosis and tumor margin assessment during pancreatic cancer surgery with the MasSpec Pen technology.

Cited by 2 publications

References 7 publications

Direct sub‐atmospheric pressure ionization mass spectrometry: Evaporation/sublimation‐driven ionization is amazing, fundamentally, and practically

Direct sub‐atmospheric pressure ionization mass spectrometry: Evaporation/sublimation‐driven ionization is amazing, fundamentally, and practically

Primary hyperparathyroidism: from guidelines to outpatient clinic

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