Magnesium Alloys as Promising Degradable Implant Materials in Orthopaedic Research

Reifenrath, Janin; Bormann, Dirk; Meyer‐Lindenberg, Andrea

doi:10.5772/14143

Cited by 35 publications

(59 citation statements)

References 39 publications

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“…Therefore, they could avoid the development of stress shielding when used as implants [4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Mg is an essential element of the human body, and also the second most important cation in cells.…”

Section: Introductionmentioning

confidence: 99%

In vitro study of polycaprolactone/bioactive glass composite coatings on corrosion and bioactivity of pure Mg

Yang

Michalczyk

Singer

et al. 2015

Applied Surface Science

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Section: Introductionmentioning

confidence: 99%

In vitro study of polycaprolactone/bioactive glass composite coatings on corrosion and bioactivity of pure Mg

Yang

Michalczyk

Singer

et al. 2015

Applied Surface Science

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“…For orthopaedic applications, alloying elements, especially the rare earths, are predominantly used to enhance the primary strength and to slow down the degradation rate [11] .…”

Section: Magnesium Implants Induced Minor Tissue Responses In Contrasmentioning

confidence: 99%

“…Magnesium alloys, having a low corrosion rate, are preferable for applications in the bone [11] . A high corrosion rate results in gas formation and a rapid loss of mechanical strength [12] .…”

Section: Introductionmentioning

confidence: 99%

Assessment of Cellular Reactions to Magnesium as Implant Material in Comparison to Titanium and to Glyconate Using the Mouse Tail Model

Reifenrath

Badar

Dziuba

et al. 2013

Journal of Applied Biomaterials & Functional Materials

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Purpose Nowadays, research in magnesium alloys as a biodegradable implant material has increased. The aim of this study was to examine osteoinductive properties and tissue responses to pure magnesium in comparison to conventional permanent (titanium) and to degradable (glyconate) implant materials. Methods Magnesium wires (0.4 mm in diameter, 10 mm length) were implanted into tail veins of mice and examined after 2, 4, 8, 16 and 32 weeks. Titanium and glyconate as controls were assessed after 2, 4, 8 and 24 weeks. μ-computed tompgraphy, histology and SEM examinations were performed. Results Magnesium implants showed increasing structural losses over time with fragmentation after an observation period of 32 weeks. Glyconate was fully degraded and titanium remained almost unaffected after 24 weeks. In contrast to some titanium and glyconate implants, first calcium and phosphate precipitations could be observed around magnesium implants after two weeks. However, ossification could not be observed even after 32 weeks, whereas enchondral ossification was found partially in the sourrounding of glyconate and titanium implants after eight weeks. Nevertheless, magnesium implants showed less inflammatory responses and fibrosing properties than the conventional implant materials. Conclusions Although the assumed osteoinductive properties could not be detected, magnesium appears to be a promising degradable implant material because of the low sensitizing and inflammatory potential.

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“…[13][14][15][16][17][18][19][20][21] ZEK100 pins have shown promising initial mechanical stability. 15,20 Lensing et al reported good biocompatibility and an osteoconductive effect of ZEK100 in the middle ear of rabbit. 17 In contrast, some studies have shown that the biocompatibility of the ZEK100 alloy appears to be questionable.…”

Section: Introductionmentioning

confidence: 99%

Comparative in vitro study and biomechanical testing of two different magnesium alloys

et al. 2013

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In this in vitro study, magnesium plates of ZEK100 and MgCa0.8 alloy similar to common titanium alloy osteosynthesis plates were investigated as degradable biomedical materials with a focus on primary stability. Immersion tests were performed in Hank's Balanced Salt Solution at 37 C. The bending strength of the samples was determined using the fourpoint bending test according to ISO 9585:1990. The initial strength of the noncorroded ZEK100 plate was 11% greater than that of the MgCa0.8 plate; both were approximately 65% weaker than a titanium plate. The bending strength was determined after 48 and 96 h of immersion in Hank's Balanced Salt Solution; both magnesium alloys decreased by approximately 7% after immersion for 96 h. The degradation rate and the Mg 2þ release of ZEK100 were lower than those of MgCa0.8. Strong pitting and filiform corrosion were observed in the MgCa0.8 samples after 96 h of immersion. The surface of the ZEK100 plates exhibited only small areas of filiform corrosion. The results of this in vitro study indicate that the ZEK100 alloy may be more suitable for biomedical applications.

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Magnesium Alloys as Promising Degradable Implant Materials in Orthopaedic Research

Cited by 35 publications

References 39 publications

In vitro study of polycaprolactone/bioactive glass composite coatings on corrosion and bioactivity of pure Mg

In vitro study of polycaprolactone/bioactive glass composite coatings on corrosion and bioactivity of pure Mg

Assessment of Cellular Reactions to Magnesium as Implant Material in Comparison to Titanium and to Glyconate Using the Mouse Tail Model

Comparative in vitro study and biomechanical testing of two different magnesium alloys

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