Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis

Abstract

Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H2O2 without any external light or voltage. The corrosion of Mg transfers electrons to Au-decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H2O2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H2O2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated.

Osteogenic Potential of Magnesium (Mg)-Doped Multicomponent Bioactive Glass: In Vitro and In Vivo Animal Studies

“…Pro-angiogenic activity of Mg is regarded as a further added value for its usability in bone tissue engineering. Indeed, Mg can promote angiogenesis through enhancing the production of reactive oxygen species as well as through upregulating VEGF expressions in human endothelial cells [ 33 ]. Furthermore, it has been demonstrated that this element may increase new blood vessel formation, leading to improved bone reconstruction in vivo [ 34 , 35 ].…”

ZnO Nanopillar Coated Surfaces with Substrate‐Dependent Superbactericidal Property

“…In fact, electrons on conduction band (CB) of ZnO are able to generate superoxide ( • O 2 − ) . It is known that certain metal can donate electrons to metal oxide semiconductors by a self‐corrosive process . Therefore, it is proposed that electrons are donated from Zn to ZnO (CB) via interface effect and reduce oxygen molecules to superoxides in water.…”

Influence of Magnetic Fields on Electrochemical Reactions of Redox Cofactor Solutions

“…By repeating the chronoamperometry experiments in solutions purged with N 2 , a common approach for reducing O 2 concentration, [46] no significant differences on magnetically induced current increase at 1 T were observed as compared to the normal solution preparation (Figure 4 f). These results indicate negligible effects of superoxide on magnetically induced current increases at the recessed electrode, potentially due to the extremely fast spin relaxation of the superoxide (within a nanosecond) even if a [FMNH .…”