Magnesium for treating sickle cell disease

Than, Nan Nitra; Soe, Htoo Htoo Kyaw; Palaniappan, Senthil K; Abas, Adinegara BL; Franceschi, Lucia De

doi:10.1002/14651858.cd011358

Cited by 8 publications

(12 citation statements)

References 71 publications

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“…Waist circumference (WC) was measured at a point midway between the lowest rib and the iliac crest in a horizontal plane using non-elastic tape. Height, weight and WC were measured by trained examiners following a standard protocol from the WHO ( 19 ) . Height, weight and WC measurements were made at the same location and the same protocol was followed at each study visit.…”

Section: Methodsmentioning

confidence: 99%

Association between serum magnesium and blood lipids: influence of type 2 diabetes and central obesity

Zhang

Lian-sen

et al. 2018

Br J Nutr

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To assess the changes in the relationship between serum Mg and blood lipids of Chinese adults with type 2 diabetes (T2D) or central obesity, a total of 8163 subjects (mean age 59·6 years, 54·9 % men) were analysed. Participants were classified according to blood Mg (below 0·65 mmol/l, 0·65-0·95 mmol/l and above 0·95 mmol/l), T2D (yes/no) and central obesity (yes/no). Blood lipids (TAG, total cholesterol (TC), HDL-cholesterol and LDL-cholesterol) were determined by standardised methods and conditions. A significant increase in blood lipids, with the exception of HDL-cholesterol, across progressive Mg groups in all subjects was noted (P0·05). TAG, TC, HDL-cholesterol and LDL-cholesterol were significantly higher among subjects with T2D than those without T2D (P<0·05). Multivariable models for TAG and LDL-cholesterol failed to attain statistical significance in diabetics, by using a generalised linear or parsimonious model. TAG, TC, HDL-cholesterol and LDL-cholesterol were significantly higher among subjects with T2D or central obesity. Blood lipids, with the exception of HDL-cholesterol, were associated with serum Mg, but this association was somehow influenced by T2D in LDL-cholesterol. In addition, multivariable models for both TAG and LDL-cholesterol failed to attain statistical significance among subjects with T2D, different from subjects without T2D.

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Section: Methodsmentioning

confidence: 99%

Association between serum magnesium and blood lipids: influence of type 2 diabetes and central obesity

Zhang

Lian-sen

et al. 2018

Br J Nutr

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“…Более высокий уровень магния в эритроцитах снижает потерю воды [20]. Не влияет на уменьшение болевого криза, продолжительность пребывания в стационаре и изменения качества жизни при лечении серповидноклеточной анемии [21], но в то же время ЛП может рассматриваться потенциальной терапевтической стратегией лечения серповидноклеточной анемии, специфически блокируя калиевые транспортные каналы [22]. Разгружает ишемический левый желудочек посредством снижения системного давления в аорте [23].…”

Section: магния хлоридunclassified

“…Higher levels of magnesium in red blood cells reduce water loss [20]. It does not affect the reduction of the pain crisis, the length of hospital stay and changes in the quality of life in the treatment of sickle cell anemia [21]. The drug can be considered a potential therapeutic strategy for the treatment of sickle cell anemia by specifically blocking potassium transport channels [22]; It unloads the ischemic left ventricle by reducing systemic pressure in the aorta [23]; improves the frequency and manifestation of ventricular and supraventricular premature complexes [24] Magnesium L-Aspartate It has a stimulating effect on the nervous system [25]; effectively and quickly compensates for magnesium deficiency among organic magnesium compounds [26] Magnesium sulfate…”

Section: Magnesium Chloridementioning

confidence: 99%

Магнийсодержащие Лекарственные Препараты: От Клинической Фармакологии До Фармацевтической Помощи (2-Я Часть)

Кирилюк¹

2021

Рецепт

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Магнийсодержащие лекарственные препараты могут применяться перорально, внутримышечно или внутривенно. Терапия магнийсодержащими препаратами должна осуществляться до нормализации концентрации магния, а курс терапии должен составлять не менее одного месяца. В статье приводятся рекомендации по применению магнийсодержащих препаратов в различных популяционных группах. Магнийсодержащие препараты можно применять во время беременности с учетом оценки пользы/риска для матери и плода. Особое внимание уделено сравнительной оценке эффективности соединений магния в клинической практике по результатам анализа статей базы данных медицинских и биологических публикаций PubMed. Установлено, что в Республике Беларусь зарегистрировано 19 магнийсодержащих препаратов, для которых рассчитано содержание свободного магния в каждой дозированной единице лекарственной формы. Разработан алгоритм оказания фармацевтическим работником грамотной фармацевтической помощи (в т. ч. фармацевтического консультирования) посетителю, обратившемуся в аптеку с вопросом о приобретении магнийсодержащих препаратов. Magnesium-containing medicines can be administered orally, intramuscularly, or intravenously. The therapy with magnesium-containing medicines should be carried out until the magnesium concentration normalizes, and the course of the therapy should be at least one month. The article provides recommendations for the use of magnesium-containing medicines in various population groups. Magnesium preparations can be used during pregnancy, taking into account the assessment of the benefit/risk to the mother and the fetus. Particular attention is paid to the comparative assessment of the effectiveness of magnesium compounds in clinical practice based on the results of the analysis of articles from the database of medical and biological publications PubMed. It was found that 19 magnesium-containing medicines are registered in the Republicof Belarus. The content of available magnesium in each dosage unit of the dosage form was calculated. There was developed the algorithm for a pharmacist to provide pharmaceutical assistance (including pharmaceutical consulting) to a visitor with a question about the purchase of magnesium-containing medicines.

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“…Height, weight, and waist measurements were taken at the same location and follow the same procedure for each study visit. Central obesity was defined by WC > 90 cm for men and >80 cm for women [7,8].…”

Section: Measurements and Definitionsmentioning

confidence: 99%

Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels

Yan

Zhang

et al. 2020

Journal of Diabetes Research

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This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P<0.05). But HDL-C was just the opposite (P<0.0001). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P<0.05). And, HDL-C was just the opposite (P<0.05). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P<0.05). But the correlation between LDL-C and ferritin was broken (P>0.05). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders.

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Magnesium for treating sickle cell disease

Cited by 8 publications

References 71 publications

Association between serum magnesium and blood lipids: influence of type 2 diabetes and central obesity

Association between serum magnesium and blood lipids: influence of type 2 diabetes and central obesity

Магнийсодержащие Лекарственные Препараты: От Клинической Фармакологии До Фармацевтической Помощи (2-Я Часть)

Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels

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