Magnesium hydroxide temporarily enhancing osteoblast activity and decreasing the osteoclast number in peri-implant bone remodelling☆

Janning, Carla; Willbold, Elmar; Vogt, Carsten; Nellesen, J.; Meyer‐Lindenberg, Andrea; Windhagen, Henning; Thorey, Fritz; Witte, Frank

doi:10.1016/j.actbio.2009.12.037

Cited by 297 publications

(214 citation statements)

References 34 publications

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“…Therefore, lithium is used in magnesium alloys in order to stabilise the corrosion layer on its alkalising effect [86]. This effect during the degradation of magnesium is further enhanced by the solution and accumulation of magnesium hydroxide as the main degradation product [92].…”

Section: Magnesium Alloys For Cardiovascular Implantsmentioning

confidence: 99%

Cardiovascular Applications of Magnesium Alloys

Schilling¹,

Bauer²,

LaLonde³

et al. 2017

Magnesium Alloys

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Therapy in cardiovascular medicine often relies on implantation of prosthetic materials or application of stents. The diseases of many cardiovascular structures require their complete and immediate repair by utilising prosthetic materials. The ideal cardiovascular prosthesis involves good functional properties, capability of regeneration and does not activate the host's immune system. Ideally, the graft can be applied for a temporary use and degrades after a predefined period according to controlled degradation kinetics. Only biological grafts would provide this spectrum of properties by today's level of knowledge. However, biological prostheses exhibit some relevant drawbacks as well, such as insufficient mechanical stability or restricted availability. Implants or supporting structures of magnesium alloys would bridge this gap and would either provide a substrate for innovative and temporary grafts or would-as supporting structures-transiently add some missing properties to regenerative biological prostheses. This chapter reviews the different fields of cardiovascular therapeutic applications of magnesium alloys. The required properties of magnesium alloys and their preparation, fabrication and testing will be discussed under the specific cardiovascular perspective.

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Section: Magnesium Alloys For Cardiovascular Implantsmentioning

confidence: 99%

Cardiovascular Applications of Magnesium Alloys

Schilling¹,

Bauer²,

LaLonde³

et al. 2017

Magnesium Alloys

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show abstract

“…Based on histological data and from implant pull out forces, bone conductive properties of magnesium alloy implants were observed and proposed to be mediated by magnesium hydroxides as well as by calcium phosphates present in the magnesium corrosion layer [17][18][19][20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

Differential magnesium implant corrosion coat formation and contribution to bone bonding

Rahim

Weizbauer

Evertz

et al. 2016

J Biomedical Materials Res

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Magnesium alloys are presently under investigation as promising biodegradable implant materials with osteoconductive properties. To study the molecular mechanisms involved, the potential contribution of soluble magnesium corrosion products to the stimulation of osteoblastic cell differentiation was examined. However, no evidence for the stimulation of osteoblast differentiation could be obtained when cultured mesenchymal precursor cells were differentiated in the presence of metallic magnesium or in cell culture medium containing elevated magnesium ion levels. Similarly, in soft tissue no bone induction by metallic magnesium or by the corrosion product magnesium hydroxide could be observed in a mouse model. Motivated by the comparatively rapid accumulation solid corrosion products physicochemical processes were examined as an alternative mechanism to explain the stimulation of bone growth by magnesium-based implants. During exposure to physiological solutions a structured corrosion coat formed on magnesium whereby the elements calcium and phosphate were enriched in the outermost layer which could play a role in the established biocompatible behavior of magnesium implants. When magnesium pins were inserted into avital bones, corrosion lead to increases in the pull out force, suggesting that the expanding corrosion layer was interlocking with the surrounding bone. Since mechanical stress is a wellestablished inducer of bone growth, volume increases caused by the rapid accumulation of corrosion products and the resulting force development could be a key mechanism and provide an explanation for the observed stimulatory effects of magnesium-based implants in hard tissue.

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“…MIM of Mg, in particular, seems to be very attractive since Mg alloys were identified as being a highly suitable biodegradable orthopedic implant material for biomedical applications [7][8][9][10][11][12][13][14][15][16][17]. MIM of Mg alloys can be used for the industrial economic near net shape mass production of such complex-shaped implants at high reproducibility in large numbers.…”

Section: Introductionmentioning

confidence: 99%

Metal Injection Molding (MIM) of Magnesium and Its Alloys

Wolff

Schaper

Suckert

et al. 2016

Metals

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Current research has highlighted that magnesium and its alloys as biodegradable material are highly suitable for biomedical applications. The new material fully degrades into nontoxic elements and offers material properties matching those of human bone tissue. As biomedical implants are rather small and complex in shape, the metal injection molding (MIM) technique seems to be well suited for the near net shape mass production of such parts. Furthermore, MIM of Mg-alloys is of high interest in further technical fields. This study focusses on the performance of MIM-processing of magnesium alloy powders. It includes Mg-specific development of powder blending, feedstock preparation, injection molding, solvent and thermal debinding and final sintering. Even though Mg is a highly oxygen-affine material forming a stable oxide layer on each particle surface, the material can be sintered to nearly dense parts, providing mechanical properties matching those of as cast material. An ultimate tensile strength of 142 MPa, yield strength of 67 MPa, elastic modulus of 40 GPa and 8% elongation at fracture could be achieved using novel organic polymer binders for the feedstock preparation. Thus, first implant demonstrator parts could be successfully produced by the MIM technique.

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Magnesium hydroxide temporarily enhancing osteoblast activity and decreasing the osteoclast number in peri-implant bone remodelling☆

Cited by 297 publications

References 34 publications

Cardiovascular Applications of Magnesium Alloys

Cardiovascular Applications of Magnesium Alloys

Differential magnesium implant corrosion coat formation and contribution to bone bonding

Metal Injection Molding (MIM) of Magnesium and Its Alloys

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