Magnesium Is a Vital Ion in the Body—It Is Time to Consider Its Supplementation on a Routine Basis

Pethő, Ákos Géza; Fülöp, Tibor; Orosz, Petronella; Tapolyai, Mihály

doi:10.3390/clinpract14020040

Cited by 5 publications

(1 citation statement)

References 108 publications

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“…It also affects the leukocyte activity, and the expression of adhesion molecules such as the selectins, integrins LFA-1 and VLA-4, and ICAM-1 (Intercellular Adhesion Molecule 1), VCAM-1 (Vascular Cell Adhesion Molecule 1), and PECAM-1 (Platelet Endothelial Cell Adhesion Molecule), which are pivotal in the inflammatory process [ 30 , 31 , 32 ]. Clinical trials and observational studies have begun to explore the effects of magnesium supplementation on various inflammatory diseases, with preliminary findings suggesting potential benefits in reducing disease severity and enhancing quality of life for patients [ 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Does Magnesium Provide a Protective Effect in Crohn’s Disease Remission? A Systematic Review of the Literature

Costescu,

Bratosin,

Popa

et al. 2024

Nutrients

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This systematic review evaluates the hypothesis that optimal serum magnesium levels may enhance remission rates in Crohn’s disease (CD) and considers whether magnesium supplementation could be beneficial in CD management. This review aims to synthesize available evidence concerning the impact of serum magnesium on disease remission in CD, and to analyze the effectiveness and mechanistic roles of magnesium supplementation. Adhering to the PRISMA guidelines, we searched PubMed, Web of Science, and Scopus up to January 2024 using MeSH terms and free-text queries related to CD and magnesium. The inclusion criteria were studies that investigated serum magnesium levels, effects of supplementation, and the inflammatory mechanisms in CD remission. From the 525 records identified, eight studies met the inclusion criteria after the removal of duplicates and irrelevant records. These studies, conducted between 1998 and 2023, involved a cumulative sample of 453 patients and 292 controls. Key findings include significantly lower serum magnesium levels in CD patients (0.79 ± 0.09 mmol/L) compared to controls (0.82 ± 0.06 mmol/L), with up to 50% prevalence of hypomagnesemia in CD patients observed in one study. Notably, CD patients, particularly men, exhibited lower magnesium intake (men: 276.4 mg/day; women: 198.2 mg/day). Additionally, low magnesium levels correlated with increased sleep latency (95% CI −0.65 to −0.102; p = 0.011) and decreased sleep duration (95% CI −0.613 to −0.041; p = 0.028). Another key finding was the significant association between low serum magnesium levels and elevated CRP levels as an indicator of CD disease activity. The findings support the hypothesis that serum magnesium levels are significantly lower in CD patients compared to healthy controls and suggest that magnesium supplementation could improve CD management by enhancing remission rates and sleep quality. However, more rigorous, evidence-based research is necessary to define specific supplementation protocols and to fully elucidate the role of magnesium in CD pathophysiology.

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Section: Introductionmentioning

confidence: 99%

Does Magnesium Provide a Protective Effect in Crohn’s Disease Remission? A Systematic Review of the Literature

Costescu,

Bratosin,

Popa

et al. 2024

Nutrients

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Hypomagnesaemia, an independent risk factor for the development of post‐transplant diabetes mellitus in liver and renal transplant recipients? A systematic review

Chen,

Bowen,

Liu

et al. 2024

J Human Nutrition Diet

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BackgroundPost‐transplantation diabetes mellitus (PTDM) is common after solid organ transplantation. In the past decade, there has been increasing interest in the association between hypomagnesaemia and the development of PTDM. This systematic review aimed to investigate the current knowledge regarding the association between hypomagnesaemia and PTDM in adult liver and renal transplant recipients.MethodsA literature search of five databases, Medline, Embase, ProQuest, Scopus and Google Scholar, as well as article reference lists, was performed. Eligible studies that focused on adult liver and renal transplant recipients without pretransplantation hyperglycaemia or diabetes were included. Other eligibility criteria included quantitative studies which reported magnesium concentrations, studies with at least 6 months of follow‐up, and studies published in English. The Newcastle–Ottawa Assessment Tool was used for the quality assessment.ResultsIn total, 12 studies were included in the final analysis. Eleven focused on renal transplantation and one on liver transplantation. All studies were medium to high quality with eight out of 12 achieving the highest rating of nine. Eight studies found a negative association between either pretransplant or early post‐transplant serum magnesium concentration and the risk of PTDM, three studies found no association between these two variables, and one study found a positive association between the magnesium concentration at 8 weeks after transplantation and glycosylated haemoglobin A1C.ConclusionsFurther large‐scale prospective studies with at least 6 months of follow‐up are needed to confirm these findings, particularly in liver transplantation, to further clarify and explore the relationship between hypomagnesaemia and PTDM.

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The effects of magnesium supplementation in autoimmune rheumatic diseases

Haimi,

Lerner,

de Carvalho

et al. 2024

Academia Medicine

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Magnesium Is a Vital Ion in the Body—It Is Time to Consider Its Supplementation on a Routine Basis

Cited by 5 publications

References 108 publications

Does Magnesium Provide a Protective Effect in Crohn’s Disease Remission? A Systematic Review of the Literature

Does Magnesium Provide a Protective Effect in Crohn’s Disease Remission? A Systematic Review of the Literature

Hypomagnesaemia, an independent risk factor for the development of post‐transplant diabetes mellitus in liver and renal transplant recipients? A systematic review

The effects of magnesium supplementation in autoimmune rheumatic diseases

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