Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data

Abstract

This study was aimed to assess the effectiveness of magnesium (Mg)-vitamin B 6 replenishment and its correlation with clinical status in pregnant women (PW), and quality of life in women with hormone-related conditions (HRCW) and hypomagnesemia (HME). Data collected in four observational studies were pooled and analysed. All women received Mg supplementation for 4 weeks. The proportion of women with normalized Mg level, and the correlation between serum Mg dynamics and number of symptoms/complaints (PW) or changes in World Health Organization quality of life questionnaire scores (WHOQOL; HRCW) were evaluated. 869 PW and 957 HRCW were included in the study. Normalization of serum Mg level to ≥ 0.66 mmol/L occurred in 92.1% of PW and 78.4% of HRCW, and to ≥ 0.8 mmol/L in 73.8% and 58.9%, respectively. Mg normalization was accompanied by a median decrease of 1 symptom and 1 complaint in PW. Serum Mg level increase by 0.1 mmol/L was associated to significant changes in the WHOQOL scores in HRCW. Treatment of HME with the Mg for approximately 4 weeks provided a high response rate of Mg serum level, was associated with an improvement in symptom severity and complaints in PW, and WHOQOL score in HRCW. A 0.8 mmol/L cut-off appeared to be more relevant in terms of patient-reported outcomes.

Risk factors and comorbidities associated with magnesium deficiency in pregnant women and women with hormone-related conditions: Analysis of a large real-world dataset

“…Participants of observational studies MAGIC, MAGIC2, MAGYN and MAGYN2 received magnesium supplements prescribed by treating physicians in accordance to routine clinical practice; a proportion of participants received magnesium-vitamin B6 combination (Magne B 6 /Magne B 6 Forte) [19,18,20,21]. The effectiveness results are presented in detail elsewhere [22]. Brie y, after taking magnesium supplements for four weeks, 293 of 318 (92.1%) pregnant women with initial level < 0.66 mmol/L achieved magnesium level ≥ 0.66 mmol/L, and 529 of 717 (73.8%) pregnant women with initial level < 0.8 mmol/L achieved magnesium level ≥ 0.8 mmol/L.…”