Magnesium oxide-poly(ε-caprolactone)-chitosan-based composite nanofiber for tissue engineering applications

Rijal, Nava P.; Adhikari, Udhab; Khanal, Shalil; Pai, Devdas; Sankar, Jagannathan; Bhattarai, Narayan

doi:10.1016/j.mseb.2017.11.006

Cited by 72 publications

(39 citation statements)

References 40 publications

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“…Due to its bioactivity and biodegradability Ch is popular among pharmaceutical, medical and cosmetic concerns. It is used primarily as a support for the supply of drugs and proteins (Moradi et al 2019), biosensors (Zhang et al 2018), nanofibers (scaffolds in tissue engineering) (Rijal et al 2018;Bhowmick et al 2018). In the area of life science, titanium dioxide (TiO 2 ) is also often found, which is generally associated with its role as natural, physical UV filter or drug filler.…”

Section: Introductionmentioning

confidence: 99%

Langmuir monolayer study of phospholipid DPPC on the titanium dioxide–chitosan–hyaluronic acid subphases

2019

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The studies of model biological membranes consisted of phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were carried out by means of the Langmuir monolayer technique using subphases containing chitosan (Ch), titanium (IV) oxide (TiO 2 ), hyaluronic acid (HA) or mixture of them. The aim was to determine the effect of individual components of subphase and their respective combinations on behavior of the DPPC membrane. The systems were tested at room temperature (20 °C) and at a natural pH of about 4.8, which was close to the pH of the human skin (4.7-5.6). The surface pressure-area per molecule (π-A) isotherms were obtained. Their analysis showed that all substances studied affected the phospholipid membrane which was revealed in the changes of mean molecular area, compression modulus and pressure of the liquidexpanded/liquid-condensed (LE/LC) phase transition. The results were discussed in terms of the nature and strength of mutual interactions. The more profound effect was found at low surface pressures at which the monolayers occurred in more expanded state. However, at the surface pressure corresponding to that of biological membranes, systems had very similar parameters compared to model DPPC isotherm.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Section: Introductionmentioning

confidence: 99%

Langmuir monolayer study of phospholipid DPPC on the titanium dioxide–chitosan–hyaluronic acid subphases

2019

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“…14,15 The natural polymer provides a good cell attraction and provides a platform for cells to proliferate and differentiate. 16,17 Physically, nanofibers provide high porosity and surface area to facilitate transportation of nutrients and cell attachment. 18 A natural polymer also has a good degradation property to comply with the implant material while a synthetic polymer provides a structural integrity to the nanofiber scaffold to survive in various condition and load bearing.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Yusof

Shamsudin

Abdullah

et al. 2018

Polymers for Advanced Techs

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Carboxymethyl starch (CMS) is a natural polymer derived from sago starch that is obtained from sago palm (Metroxylon spp.). Herein, CMS was used as a polysaccharide source in preparations of composite nanofibers with poly(L‐lactide acid) (PLLA). The incorporation of CMS with PLLA in nanofiber form has great potential to be used in biomedical applications. The composite PLLA/CMS nanofibers were fabricated by electrospinning technique at various ratios of CMS, which were 5, 10, 15, and 20% vol/vol. The composite nanofibers were characterized according to their physical morphology, chemical interaction, wettability, water uptake, and thermal and mechanical behaviors. The result showed that uniform and bead‐free nanofibers were produced at the low ratio of CMS while fractal and discontinuing fiber was observed at a high ratio of CMS. A better mechanical strength was obtained at low CMS ratio as compared with higher one. Fourier transform infrared results showed that there was an interaction between CMS and PLLA after electrospinning. The surface hydrophilicity and water uptake increased with increasing ratio of CMS. The results from the differential scanning calorimeter analysis showed the decrease of the glass transition (Tg) and cold crystallization temperature (Tcc) of the nanofiber after addition of CMS in PLLA.

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“…[194] PCL-Chitosan MgO TFE and water -Fibrous scaffolds with tunable physical properties were fabricated. [195] PEA rGO CF and DMF…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Multi-Functional Electrospun Nanofibers from Polymer Blends for Scaffold Tissue Engineering

Hanumantharao

Rao

2019

Fibers

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Electrospinning and polymer blending have been the focus of research and the industry for their versatility, scalability, and potential applications across many different fields. In tissue engineering, nanofiber scaffolds composed of natural fibers, synthetic fibers, or a mixture of both have been reported. This review reports recent advances in polymer blended scaffolds for tissue engineering and the fabrication of functional scaffolds by electrospinning. A brief theory of electrospinning and the general setup as well as modifications used are presented. Polymer blends, including blends with natural polymers, synthetic polymers, mixture of natural and synthetic polymers, and nanofiller systems, are discussed in detail and reviewed.

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Magnesium oxide-poly(ε-caprolactone)-chitosan-based composite nanofiber for tissue engineering applications

Cited by 72 publications

References 40 publications

Langmuir monolayer study of phospholipid DPPC on the titanium dioxide–chitosan–hyaluronic acid subphases

Langmuir monolayer study of phospholipid DPPC on the titanium dioxide–chitosan–hyaluronic acid subphases

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Multi-Functional Electrospun Nanofibers from Polymer Blends for Scaffold Tissue Engineering

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