2024
DOI: 10.1021/acs.jpcb.4c03981
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Magnesium Regulates RNA Ring Dynamics and Folding in Subgenomic Flaviviral RNA

Avijit Mainan,
Rimi Kundu,
Rishabh K. Singh
et al.

Abstract: Mosquito-borne flaviviruses including dengue, Zika, yellow fever, and regional encephalitis produce a large amount of short subgenomic flaviviral RNAs during infection. A segment of these RNAs named as xrRNA1 features a multi-pseudoknot (PK)associated structure, which resists the host cell enzyme (XRN1) from degrading the viral RNA. We investigate how this long-range RNA PK folds in the presence of counterions, specifically in a mix of monovalent (K + ) and divalent (Mg 2+ ) salts at physiological concentratio… Show more

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