Magnesium Supplementation: Effect on the Expression of Inflammation Genes in Erlich's Tumor

Draghi, Patricia Ferrante; Fernandes, Julio Cesar B.; Petri, Giuliana; Silva, Emerson Barbosa da; Perez, Matheus Moreira; Veiga, Gláucia Luciano da; Alves, Beatriz da Costa Aguiar; Fonseca, Fernando Luiz Affonso

doi:10.1080/19390211.2021.1897056

Cited by 2 publications

(1 citation statement)

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“…In addition, intratumor injection of MgCl 2 was recently proven to enhance cellular immunity by regulating CD8 + T-cell activation and cytotoxicity [ 73 ]. In addition, magnesium supplementation has the potential to combat cisplatin resistance [ 82 ] and to modulate inflammatory factors, such as tumor necrosis factor (TNF-α) [ 83 ].…”

Section: The Application Of Metal Ion-based Antitumor Therapeutics An...mentioning

confidence: 99%

Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective

Shen

Fang

et al. 2023

J Nanobiotechnol

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The slightest change in the extra/intracellular concentration of metal ions results in amplified effects by signaling cascades that regulate both cell fate within the tumor microenvironment and immune status, which influences the network of antitumor immunity through various pathways. Based on the fact that metal ions influence the fate of cancer cells and participate in both innate and adaptive immunity, they are widely applied in antitumor therapy as immune modulators. Moreover, nanomedicine possesses the advantage of precise delivery and responsive release, which can perfectly remedy the drawbacks of metal ions, such as low target selectivity and systematic toxicity, thus providing an ideal platform for metal ion application in cancer treatment. Emerging evidence has shown that immunotherapy applied with nanometallic materials may significantly enhance therapeutic efficacy. Here, we focus on the physiopathology of metal ions in tumorigenesis and discuss several breakthroughs regarding the use of nanometallic materials in antitumor immunotherapeutics. These findings demonstrate the prominence of metal ion-based nanomedicine in cancer therapy and prophylaxis, providing many new ideas for basic immunity research and clinical application. Consequently, we provide innovative insights into the comprehensive understanding of the application of metal ions combined with nanomedicine in cancer immunotherapy in the past few years. Graphical Abstract

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Section: The Application Of Metal Ion-based Antitumor Therapeutics An...mentioning

confidence: 99%