Magnetic Dual-template Molecularly Imprinted Polymer Nanoparticles for the Simultaneous Determination of Acetaminophen and Codeine in Urine Samples by Ion Mobility Spectrometry

Abstract

Dual-template magnetic molecularly imprinted polymer nanoparticles were synthesized and used for the solid-phase extraction of acetaminophen and codeine before simultaneous determination by corona discharge ion mobility spectrometry. The magnetic molecularly imprinted polymer nanoparticles were prepared using silica-coated magnetic nanoparticles as supporters, acetaminophen and codeine as template molecules, 3-aminopropyltriethoxysilane and phenyltriethoxysilane as functional monomers, and tetraethoxysilane as a cross-linker. The obtained molecularly imprinted polymer was characterized by transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy. The adsorption performance of the imprinted polymers was studied by a series of experiments, indicating a satisfactory recognition ability of products for acetaminophen and codeine. The detection limits of 0.05 and 0.12 μg mL, and the dynamic range of 0.20 - 2.0 and 0.40 - 3.0 μg mL were achieved for acetaminophen and codeine, respectively. The proposed method was used for simultaneous determinations of acetaminophen and codeine in urine samples, and the corresponding recoveries were calculated in the range of 87 - 94%. These satisfactory results revealed the ability of the method for a routine analysis of acetaminophen and codeine, simultaneously.

Vortex-Assisted Dispersive Molecularly Imprinted Polymer-Based Solid Phase Extraction of Acetaminophen from Water Samples Prior to HPLC-DAD Determination

“…The evaluated adsorption capacity is as compared with other related ACT-MIP sorbents described in the literature. The current adsorption capacity was 380, 13, and 1.6 times higher than those reported by [33,42], respectively.…”

Design of imprinting matrix for dual template sensing via electropolymerized polythiophene films

“…Recently, imprinting fraternity extended this methodology for double or multiple templates on a single imprinting matrix. [1][2][3][4][5][6][7][8][9][10] Many advantages are foreseen in principle for such dual/multi-template imprinting like simultaneous extraction, lower solvent consumption, cost-effectiveness, short analysis time, etc, are few of them. Fluoroquinilones, ciprofloxacin and norfloxacin were imprinted simultaneously and showed better selectivity than polymeric matrix imprinted with individual templates.…”

Preparation of Molecularly Imprinted Magnetic Graphene Oxide-Gold Nanocomposite and Its Application to the Design of Electrochemical Sensor for Determination of Epinephrine

“…22 MIPs, and synthesized chemicals could be insulated by the use of an external magnetic field. 32 Therefore, a compound is quickly dissipated by magnetization, then the MIP provides a powerful analytical device with simplicity, flexibility and selectivity. 33 In this work, a new material composed of MGR-Ox-AuNPs and MIPs was synthesized by employing EPN as a template molecule, then an electrochemical sensor was designed to measure EPN in biological samples.…”