Magnetic Field Effect on the Magnetic Nanoparticles Trajectories in Pulsating Blood Flow: a Computational Model

Roa-Barrantes, Laura Maŕıa; Patarroyo, Diego Julián Rodríguez

doi:10.1007/s12668-022-00949-3

BioNanoSci.

2022

DOI: 10.1007/s12668-022-00949-3

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Magnetic Field Effect on the Magnetic Nanoparticles Trajectories in Pulsating Blood Flow: a Computational Model

Laura Maŕıa Roa-Barrantes

Diego Julián Rodríguez Patarroyo

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Cited by 8 publications

References 25 publications

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An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow

Wirthl,

Janko,

Lyer

et al. 2023

Biomed Microdevices

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One of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at sufficiently high doses while at the same time affecting healthy tissue and causing significant side effects and suffering in cancer patients. To overcome this deficiency, magnetic nanoparticles as transporter systems have emerged as a promising approach to achieve more specific tumour targeting. Drug-loaded magnetic nanoparticles can be directed to the target tissue by applying an external magnetic field. However, the magnetic forces exerted on the nanoparticles fall off rapidly with distance, making the tumour targeting challenging, even more so in the presence of flowing blood or interstitial fluid. We therefore present a computational model of the capturing of magnetic nanoparticles in a test setup: our model includes the flow around the tumour, the magnetic forces that guide the nanoparticles, and the transport within the tumour. We show how a model for the transport of magnetic nanoparticles in an external magnetic field can be integrated with a multiphase tumour model based on the theory of porous media. Our approach based on the underlying physical mechanisms can provide crucial insights into mechanisms that cannot be studied conclusively in experimental research alone. Such a computational model enables an efficient and systematic exploration of the nanoparticle design space, first in a controlled test setup and then in more complex in vivo scenarios. As an effective tool for minimising costly trial-and-error design methods, it expedites translation into clinical practice to improve therapeutic outcomes and limit adverse effects for cancer patients. Graphic Abstract

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An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow

Wirthl,

Janko,

Lyer

et al. 2023

Biomed Microdevices

View full text Add to dashboard Cite

show abstract

Quantification of the efficiency of magnetic targeting of nanoparticles using finite element analysis

Casallas,

Patarroyo,

Benavides

2023

J Nanopart Res

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The lack of efficient drug delivery to tumor cells has led to investigations into the administration of magnetic drugs, which use magnetic fields to target treatment to specific organs, thereby reducing side effects compared to traditional treatments. The dynamics of MTD in breast arteries are currently unknown and can be modeled using second-order differential equations. Blood flow is generally assumed to be a non-Newtonian fluid due to its viscosity characteristics. In this study, we modeled the targeting efficiency of magnetic nanoparticles with sizes of 50 nm, 100 nm, and 200 nm under a constant magnetic field of 0.12 T using a computational tool based on the finite element technique. Our results showed that magnetic nanoparticle targeting efficiency was highest with simulated magnetic fields located 5 cm, 7.5 cm, and 15 cm away from the tumor when using nanoparticles of 50 nm and 100 nm.

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Comment on the Paper “Magnetic Field Effect on the Magnetic Nanoparticles Trajectories in Pulsating Blood Flow: a Computational Model, BioNanoScience (2022) 12:571–581”

Pantokratoras

2023

BioNanoSci.

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Magnetic Field Effect on the Magnetic Nanoparticles Trajectories in Pulsating Blood Flow: a Computational Model

Cited by 8 publications

References 25 publications

An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow

An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow

Quantification of the efficiency of magnetic targeting of nanoparticles using finite element analysis

Comment on the Paper “Magnetic Field Effect on the Magnetic Nanoparticles Trajectories in Pulsating Blood Flow: a Computational Model, BioNanoScience (2022) 12:571–581”

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