The Catteno–Christov heat flux plays a dynamic role in flow of heat enhancement in various manufacturing, industrial, and engineering applications. This present work focuses on the influence of Catteno–Christov heat flux model on Darcy–Forchheimer flow of a hybrid nanofluid placed in a porous medium. The formulation of the mathematical model is done by considering a fluid with two different nanoparticles Al2O3 and Cu dispersed in the water as the base fluid. The set of partial differntial equations is reduced by using similarity variables and boundary conditions to obtain ordinary differntial equations. The coupled nonlinear governing differential equations are solved using Runge–Kutta fourth–fifth order (RKF‐45). The impact of numerous dimensionless parameters on the velocity, thermal, and concentration profiles are plotted and studied. Furthermore, the coefficient of skin friction for the relevant parameters are analysed through graphs. Result reveals that, increase in the porosity parameter declines the velocity gradient and shoots up the thermal and concentration gradients. Inclination in magnetic parameter declines velocity and concentration profiles due to the Lorentz force. Enhancement in the thermal relaxation parameter declines the thermal profile. Inclination in homogeneous‐heterogeneous reaction parameters declines the mass transfer rate. Also, the well‐known differential transform method is used for the validity of RKF‐45 method and an impressive agreement is noticed between the results of RKF‐45 and DTM.