Magnetic graphene oxide as a carrier for targeted delivery of chemotherapy drugs in cancer therapy

Huang, Ya-Shu; Lu, Yu-Jen; Chen, Jyh‐Ping

doi:10.1016/j.jmmm.2016.10.042

Cited by 87 publications

(43 citation statements)

References 18 publications

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“…Recent research showed that magnetic nanoparticles (MNPs) could be attached to graphene, which can be applied in magnetic resonance imaging [15], targeted drug delivery [16,17], biocompatible adsorbent [18], magnetic solid phase extraction [19], microwave electromagnetic [20], Schottky diode applications [21], and biomolecule immobilization [22]. Thus, the bifunctional graphene drug delivery system for magnetic targeting and drug loading was developed in this paper.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Fe₃O₄/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

Zhang

Wen-bin

et al. 2017

Journal of Nanomaterials

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The Fe 3 O 4 /reduced graphene oxide (Fe 3 O 4 /RGO) nanocomposites with good dispersibility were synthesized for targeted delivery of paclitaxel (PTX). Firstly, the superparamagnetic Fe 3 O 4 /functional GO nanocomposites were prepared via hydrothermal method in which GO sheets were modified by surfactant wrapping. The Fe 3 O 4 /RGO nanocomposites were successively prepared through the reduction of graphene oxide. The products were investigated by Fourier-transform infrared spectrum, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and vibration sample magnetometry. It was found that spherical Fe 3 O 4 nanoparticles were uniformly anchored over the RGO matrix and the nanocomposites were superparamagnetic with saturation magnetization (Ms) of 9.39 emu/g. Then PTX was loaded onto Fe 3 O 4 /RGO nanocomposites, and the drug loading capacity was 67.9%. Cell viability experiments performed on MCF-7 demonstrated that the Fe 3 O 4 /RGOloaded PTX (Fe 3 O 4 /RGO/PTX) showed cytotoxicity to MCF-7, whereas the Fe 3 O 4 /RGO displayed no obvious cytotoxicity. The above results indicated that Fe 3 O 4 /RGO/PTX nanocomposites had potential application in tumor-targeted chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Preparation of Fe₃O₄/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

Zhang

Wen-bin

et al. 2017

Journal of Nanomaterials

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“…For example, it has been shown that F-functionalized graphene can be prepared using F-based plasma treatments to provide a highly stable covalent bond of C2F [50 -52]. Furthermore, to achieve local fluorination, a patterned buffer layer during the CF 4 plasma treatment has been successfully demonstrated [53].…”

Section: New Routes To Patterning Fecl 3 -Functionalized Graphene Formentioning

confidence: 99%

“…GO (and reduced GO) has been used extensively for drug delivery in cancer treatment (e.g. [2][3][4]), for the fabrication of biosensing platforms capable of detecting the presence of key disease biomarkers and DNA sequences (e.g. [5][6][7]), for the in situ bioimaging of cells [8], as well as finding application as a most effective antibacterial agent (e.g.…”

Section: Introductionmentioning

confidence: 99%

New routes to the functionalization patterning and manufacture of graphene-based materials for biomedical applications

Sanctis¹,

Russo²,

Craciun³

et al. 2018

Interface Focus.

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Graphene-based materials are being widely explored for a range of biomedical applications, from targeted drug delivery to biosensing, bioimaging and use for antibacterial treatments, to name but a few. In many such applications, it is not graphene itself that is used as the active agent, but one of its chemically functionalized forms. The type of chemical species used for functionalization will play a key role in determining the utility of any graphene-based device in any particular biomedical application, because this determines to a large part its physical, chemical, electrical and optical interactions. However, other factors will also be important in determining the eventual uptake of graphene-based biomedical technologies, in particular the ease and cost of manufacture of proposed device and system designs. In this work, we describe three novel routes for the chemical functionalization of graphene using oxygen, iron chloride and fluorine. We also introduce novel methods for controlling and patterning such functionalization on the micro- and nanoscales. Our approaches are readily transferable to large-scale manufacturing, potentially paving the way for the eventual cost-effective production of functionalized graphene-based materials, devices and systems for a range of important biomedical applications.

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“…Magnetically (Fe 3 O 4 ) modified GO functionalized with chitosan and methoxy poly (ethylene glycol) mPEG-NHS nanostructure was used for targeted drug delivery of chemotherapy drugs CPT-11 and DOX. High drug loading and pH dependent drug release properties are promising for targeted drug delivery and cancer therapy [9]. GO-Fe 3 O 4 super paramagnetic drug carrier was developed with loading of 18.6 wt% of DOX hydrochloride.…”

Section: Drug Delivery and Cancer Therapymentioning

confidence: 99%

Graphene Oxide for Biomedical Applications

K¹,

Modak²,

Paik³

2017

JNMR

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Graphene oxide (GO) is one of the most promising functional materials used in various applications like energy storage (batteries and supercapacitors) sensors, photocatalysis, electronics and in biomedicine. The last 10 years literature on GO for biomedical applications revealed and confirmed the scope of its potential capabilities as biomaterial. GO alone and its modified form with different materials (surface functionalization, immobilization of nanoparticles and composite formation) also proved as a multifunctional candidate for medical biotechnology. A material for its use in biomedical applications must be biocompatible and nontoxic to the living cells.. Although there are some concerns about the toxicity of the GO in specific cases, a dosage range and size effects reported in the literature to use it as a nontoxic materials. In view of all these points, an effort has been made to review and emphasize the scope of GO as a biomedical agent for the applications like targeted drug delivery, cancer theranostics, bioimaging and biosensors etc. Further, potential applications along with the future scope and limitations of GO have also been highlighted in this review.

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Magnetic graphene oxide as a carrier for targeted delivery of chemotherapy drugs in cancer therapy

Cited by 87 publications

References 18 publications

Preparation of Fe₃O₄/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

Preparation of Fe₃O₄/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

New routes to the functionalization patterning and manufacture of graphene-based materials for biomedical applications

Graphene Oxide for Biomedical Applications

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Magnetic graphene oxide as a carrier for targeted delivery of chemotherapy drugs in cancer therapy

Cited by 87 publications

References 18 publications

Preparation of Fe3O4/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

Preparation of Fe3O4/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

New routes to the functionalization patterning and manufacture of graphene-based materials for biomedical applications

Graphene Oxide for Biomedical Applications

Contact Info

Product

Resources

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Preparation of Fe₃O₄/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

Preparation of Fe₃O₄/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel