Magnetic nanoemulsions as drug delivery system for Foscan®: Skin permeation and retention in vitro assays for topical application in photodynamic therapy (PDT) of skin cancer

Primo, Fernando Lucas; Michieleto, Leandro; Rodrigues, Marcilene A. M.; Macaroff, P.P.; Morais, P.C.; Lacava, Z.G.M.; Bentley, Maria Vitória Lopes Badra; Tedesco, Antônio Cláudio

doi:10.1016/j.jmmm.2006.10.1183

Cited by 66 publications

(34 citation statements)

References 16 publications

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“…Numerous attempts have been made to use immunotoxins for targeted treatment of malignant lung diseases (Ally et al 2005). Finally, these novel formulations have been shown to increase the drug accumulation in the stratum corneum and epidermis plus dermis, which clearly demonstrates the potential of MNPs for topical application (Lacava et al 2002;Primo et al 2007).…”

Section: Magnetic Nanoparticles For Gene Deliverymentioning

confidence: 99%

Magnetic nanoparticle drug delivery systems for targeting tumor

et al. 2013

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Tumor hypoxia, or low oxygen concentration, is a result of disordered vasculature that lead to distinctive hypoxic microenvironments not found in normal tissues. Many traditional anti-cancer agents are not able to penetrate into these hypoxic zones, whereas, conventional cancer therapies that work by blocking cell division are not effective to treat tumors within hypoxic zones. Under these circumstances the use of magnetic nanoparticles as a drug delivering agent system under the influence of external magnetic field has received much attention, based on their simplicity, ease of preparation, and ability to tailor their properties for specific biological applications. Hence in this review article we have reviewed current magnetic drug delivery systems, along with their application and clinical status in the field of magnetic drug delivery.

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Section: Magnetic Nanoparticles For Gene Deliverymentioning

confidence: 99%

Magnetic nanoparticle drug delivery systems for targeting tumor

et al. 2013

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“…The nanoemulsions promoted better skin retention of the antioxidant (Nam et al, 2012). Primo et al (2007) formulated two nanoemulsions containing a photosensitizer for topical administration in photodynamic therapy of skin cancer and other diseases. The nanoemulsions promoted the penetration and retention of the photosensitizer in the epidermis and dermis.…”

Section: In Vitro Permeation Studiesmentioning

confidence: 99%

“…The nanoemulsions promoted the penetration and retention of the photosensitizer in the epidermis and dermis. The formulation called "magnetic nanoemulsion" promoted photosensitizer retention in the epidermis and dermis in a higher quantity than in the stratum corneum (Primo et al, 2007).…”

Section: In Vitro Permeation Studiesmentioning

confidence: 99%

Promotion of cutaneous penetration of nifedipine for nanoemulsion

Arantes

Santos

Freitas

et al. 2017

Braz. J. Pharm. Sci.

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This article reports the development and characterization of a nanoemulsion (NE) able to improve the cutaneous penetration of nifedipine. NE with nifedipine was development and characterized, presenting droplet size of 20 nm with low polydispersity index (IP<0.1), spherical shape without aggregation, pH compatible with typical skin levels and stability evaluated by seven months. In the permeation studies, a classical formulation based in an oil/water cream containing nifedipine was used for comparison with NE. Nanoemulsion promoted and improved the retention of nifedipine in the epidermis and dermis in relation to classical formulation. This promoting effect is related to the nanometric size of the droplets of the NE (20 nm), which give him a large superficial area, favoring the contact of the nanocarrier with the skin surface. The NE was efficient in promoting accumulation of nifedipine in the dermis, which is the site of vasodilation action. NE was not irritating according to the primary dermal irritation tests. NE is a promising release system to promote cutaneous penetration of nifedipine and can be used in the future in clinical trials to promote healing of lesions caused by peripheral vascular diseases.

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“…In addition to encapsulation of nanosized particles into biocompatible hosting templates therapeutic molecules can be included for further delivery as well, either within the template [99][100][101][102][103][104][105][106][107][108] or decorating the outer surface of the template or, alternatively, decorating the encapsulated nanoparticles [109][110][111][112][113][114]. Indeed, vectorization of these material systems to target specific cells and tissues can be realized extrinsically using gradients of magnetic fields [10] or intrinsically by dressing the materials' surface with cell receptor-responsive moieties [84,115].…”

Section: Thermoresponsive Drug Delivery Systemsmentioning

confidence: 99%

Remote Hyperthermia, Drug Delivery and Thermometry: The Multifunctional Platform Provided by Nanoparticles

Qi¹,

Morais

2014

J Nanomed Nanotechno

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The huge demand for biocompatible, robust, accurate and noninvasive technology to assess the temperature of a biological targeted site for monitoring the hyperthermia effect brings the topic of remote thermometry to a very high level of interest. There are already promising research directions to fulfil such demand in the short term and a review of the achievements in this issue is certainly worth. This report offers an overview of the research regarding the most promising nanothermometers nowadays, with emphasis on those addressed to remote operation while using optical or magnetic responses of nanosized materials as the thermometric property. More specifically the optical emission intensity, optical emission peak shift and optical emission lifetime will be covered as far as the optical-based nanothermometers are concerned. Additionally, for the magnetic-based nanothermometers the magnetization or the magnetic susceptibility are the thermometric properties covered in this review. Furthermore, the review includes the hyperthermia effect based on nanosized metallic or magnetic particles plus a couple of thermally-responsive polymeric drug delivery systems, aiming to provide an integrated view of the multipurpose platform offered by actuating-sensing nanoparticles. As far as the regulatory system is concerned the availability of noninvasive thermometry incorporating biocompatibility, robustness and accuracy will establish the grounds needed for the approval of the hyperthermia technology for therapeutic purposes, thus allowing the market of this technological option on a global scale.hyperthermia and thermoresponsive drug delivery systems for clinical use.Although nanothermometry is at its infancy considerable progress has been made recently in regard to its use for remote assessing the temperature at the site the nanomaterials are incorporated to. Nanoprobes allowing remote temperature-sensing using optical or magnetic properties are among the most promising directions nowadays. Most of the optical-based nanothermometers use the light-emitting intensity [15][16][17][18][19][20][21][22][23], light-emitting peak shift [24][25][26], or lifetime decay of a suitable optical band as the thermometric property [27][28][29][30]. As far as the clinical use is concerned the drawbacks of the actual optical-based nanothermometers rely on biocompatibility (usual semiconductor-based core nanoprobes or dye-based shell moieties are toxic), robustness (typical bleaching of organic-based shell moieties) or temperature accuracy (no better than 0.3°C nowadays), or even combination of these factors. Moreover, due to limitations imposed by living tissues on the optical penetration of light (optical therapeutic window in the 700-1100 nm wavelength range), noninvasive clinical use of optical excitation and signal pickup is a huge challenge, not yet solved, except for very special therapeutic applications, as for instance the photodynamic therapy for treatment (heating monitoring) of skin cancer and follow up [31]. Alternatively, ...

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Magnetic nanoemulsions as drug delivery system for Foscan®: Skin permeation and retention in vitro assays for topical application in photodynamic therapy (PDT) of skin cancer

Cited by 66 publications

References 16 publications

Magnetic nanoparticle drug delivery systems for targeting tumor

Magnetic nanoparticle drug delivery systems for targeting tumor

Promotion of cutaneous penetration of nifedipine for nanoemulsion

Remote Hyperthermia, Drug Delivery and Thermometry: The Multifunctional Platform Provided by Nanoparticles

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