Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery

Abstract

Previous attempts to review the literature on magnetic nanomaterials for hyperthermia-based therapy focused primarily on magnetic fluid hyperthermia (MFH) using mono metallic/metal oxide nanoparticles. The term “Hyperthermia” in the literature was also confined only to include use of heat for therapeutic applications. Recently, there have been a number of publications demonstrating magnetic nanoparticle-based hyperthermia to generate local heat resulting in the release of drugs either bound to the magnetic nanoparticle or encapsulated within polymeric matrices. In this review article, we present a case for broadening the meaning of the term “hyperthermia” by including thermotherapy as well as magnetically modulated controlled drug delivery. We provide a classification for controlled drug delivery using hyperthermia: Hyperthermia-based controlled Drug delivery through Bond Breaking (DBB) and Hyperthermia-based controlled Drug delivery through Enhanced Permeability (DEP). The review also covers, for the first time, core-shell type magnetic nanomaterials, especially nanoshells prepared using layer-by-layer self-assembly, for the application of hyperthermia-based therapy and controlled drug delivery. The highlight of the review article is to portray potential opportunities in the combination of hyperthermia-based therapy and controlled drug release paradigms for successful application in personalized medicine.

A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles

“…Magnetic iron oxide nanoparticles with tailored surface chemistry have been widely used experimentally for numerous in vivo applications such as magnetic resonance imaging, contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, hyperthermia, drug delivery and in cell separation [1][2][3][4][5]. Coating or modifying these nanoparticles with hydrophilic molecules, especially biomolecules, is a crucial step for the preparation of waterdispersible magnetite nanoparticles (MNPs) for use in biological applications [6].…”

Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)Responsive Coating and Their Application in Hyperthermia and Heat-Triggered Drug Delivery

“…After removal of free polymer from the reaction mixture, the polymer coated cubic-IONPs were observed to be soluble in water or phosphate buffered saline (PBS) (pH 7.4) at room temperature. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 As we sought to prepare thermo-responsive IONPs for cancer treatment with thermal response significant for hyperthermia (41-47 o C) , 15,32 we targeted coil-globule response temperatures above body temperature (37 o C) and maintaining this behavior in physiological conditions (saline buffer solutions at 155 mM of...…”

Heat generation properties in AC magnetic field for composite powder material of the Y3Fe5O12–nSiC system prepared by reverse coprecipitation method

“…The heat generation ability in an AC magnetic field for magnetic materials has been studied for the local treatment of cancerous tissues [1][2][3][4][5][6][7]. Materials of the needle type and powder type have been studied for this purpose.…”