Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents

Tegafaw, Tirusew; Liu, Shuwen; Ahmad, Mohammad Yaseen; Saidi, Abdullah Khamis Ali Al; Zhao, Dan; Liu, Ying; Nam, Sung-Wook; Chang, Yongmin; Lee, Gang Ho

doi:10.3390/pharmaceutics15061745

Cited by 14 publications

(2 citation statements)

References 116 publications

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“…The approaches proposed to design DMCAs comprise: (1) use of NPs with a single type of contrast material, Gd- or Mn-based NPs or superparamagnetic NPs with appropriate size and magnetization to provide T 2 and T 1 contrast; or (2) include both T 1 and T 2 contrast materials in the same NP. Both have advantages and disadvantages [ 31 , 69 , 70 , 71 , 72 ].…”

Section: Magnetic Nanoparticles As T 1 –T ...mentioning

confidence: 99%

Rational Design of Magnetic Nanoparticles as T1–T2 Dual-Mode MRI Contrast Agents

Geraldes

2024

Molecules

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Magnetic nanoparticles (MNPs), either paramagnetic or superparamagnetic depending on their composition and size, have been thoroughly studied as magnetic resonance imaging (MRI) contrast agents using in vitro and in vivo biomedical preclinical studies, while some are clinically used. Their magnetic properties responsible in some cases for high magnetization values, together with large surface area-to-volume ratios and the possibility of surface functionalization, have been used in MRI-based diagnostic and theranostics applications. MNPs are usually used as positive (T1) or negative (T2) MRI contrast agents, causing brightening or darkening of selected regions in MRI images, respectively. This review focusses on recent developments and optimization of MNPs containing Gd, Mn, Fe and other lanthanide ions which may function as dual-mode T1–T2 MRI contrast agents (DMCAs). They induce positive or negative contrast in the same MRI scanner upon changing its operational mode between T1-weighted and T2-weighted pulse sequences. The type of contrast they induce depends critically on their r2/r1 relaxivity ratio, which for DMCAs should be in the 2–10 range of values. After briefly discussing the basic principles of paramagnetic relaxation in MNPs, in this review, the basic strategies for the rational design of DMCAs are presented and typical examples are discussed, including in vivo preclinical applications: (1) the use of NPs with a single type of contrast material, Gd- or Mn-based NPs or superparamagnetic NPs with appropriate size and magnetization to provide T2 and T1 contrast; and (2) inclusion of both types of T1 and T2 contrast materials in the same nanoplatform by changing their relative positions.

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Section: Magnetic Nanoparticles As T 1 –T ...mentioning

confidence: 99%

Rational Design of Magnetic Nanoparticles as T1–T2 Dual-Mode MRI Contrast Agents

Geraldes

2024

Molecules

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“…Among the inorganic NPs mentioned in the introduction section, magnetic NPs (MNPs) are considered a special class with high application potential in clinical studies due to their unique superparamagnetism, biocompatibility, well-known chemistry, and low cost. MNPs are being extensively investigated as the next generation of MRI contrast agents, magnetic-based DDSs, and hyperthermia agents [113][114][115][116].…”

Section: Peptide-based Hydrogel Nanocomposites Containing Organic Npsmentioning

confidence: 99%

Peptide-Hydrogel Nanocomposites for Anti-Cancer Drug Delivery

Hajareh Haghighi,

Binaymotlagh,

Fratoddi

et al. 2023

Gels

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Cancer is the second leading cause of death globally, but conventional anticancer drugs have side effects, mainly due to their non-specific distribution in the body in both cancerous and healthy cells. To address this relevant issue and improve the efficiency of anticancer drugs, increasing attention is being devoted to hydrogel drug-delivery systems for different kinds of cancer treatment due to their high biocompatibility and stability, low side effects, and ease of modifications. To improve the therapeutic efficiency and provide multi-functionality, different types of nanoparticles (NPs) can be incorporated within the hydrogels to form smart hydrogel nanocomposites, benefiting the advantages of both counterparts and suitable for advanced anticancer applications. Despite many papers on non-peptide hydrogel nanocomposites, there is limited knowledge about peptide-based nanocomposites, specifically in anti-cancer drug delivery. The aim of this short but comprehensive review is, therefore, to focus attention on the synergies resulting from the combination of NPs with peptide-based hydrogels. This review, which includes a survey of recent advances in this kind of material, does not aim to be an exhaustive review of hydrogel technology, but it instead highlights recent noteworthy publications and discusses novel perspectives to provide valuable insights into the promising synergic combination of peptide hydrogels and NPs for the design of novel anticancer drug delivery systems.

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Recent progress and current status of surface engineered magnetic nanostructures in cancer theranostics

Dutta,

Barick,

Hassan

et al. 2024

Advances in Colloid and Interface Science

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Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents

Cited by 14 publications

References 116 publications

Rational Design of Magnetic Nanoparticles as T1–T2 Dual-Mode MRI Contrast Agents

Rational Design of Magnetic Nanoparticles as T1–T2 Dual-Mode MRI Contrast Agents

Peptide-Hydrogel Nanocomposites for Anti-Cancer Drug Delivery

Recent progress and current status of surface engineered magnetic nanostructures in cancer theranostics

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