Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy

Zhang, Fan; Lu, Gui Hong; Wen, Xiaolei; Li, Feng; Ji, Xiaoyuan; Li, Qianqian; Wu, Meiying; Cheng, Qinzhen; Yu, Ying‐Hui; Tang, Jing; Mei, Lin

doi:10.1016/j.jconrel.2020.06.015

Cited by 141 publications

(91 citation statements)

References 36 publications

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“…Recently, Zhang et al. 178 described such a system using SPIONs for targeting of a tumor and use in PTT. While the SPIONs also functioned as MRI guides, theranostics will be discussed in Section 3 .…”

Section: Magnetic Systemsmentioning

confidence: 99%

Magnetic systems for cancer immunotherapy

Day

Wixson

Shields

2021

Acta Pharmaceutica Sinica B

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Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies. Immune cell modulation through the administration of drugs, proteins, and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive tumors. Magnetic systems offer several advantages for improving the performance of immunotherapies, including increased spatiotemporal control over transport, release, and dosing of immunomodulatory drugs within the body, resulting in reduced off-target effects and improved efficacy. Compared to alternative methods for stimulating drug release such as light and pH, magnetic systems enable several distinct methods for programming immune responses. First, we discuss how magnetic hyperthermia can stimulate immune cells and trigger thermoresponsive drug release. Second, we summarize how magnetically targeted delivery of drug carriers can increase the accumulation of drugs in target sites. Third, we review how biomaterials can undergo magnetically driven structural changes to enable remote release of encapsulated drugs. Fourth, we describe the use of magnetic particles for targeted interactions with cellular receptors for promoting antitumor activity. Finally, we discuss translational considerations of these systems, such as toxicity, clinical compatibility, and future opportunities for improving cancer treatment.

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Section: Magnetic Systemsmentioning

confidence: 99%

Magnetic systems for cancer immunotherapy

Day

Wixson

Shields

2021

Acta Pharmaceutica Sinica B

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“…Whether the encapsulated drugs are successfully released and taken up by cells is the key point for evaluating drugloaded nanogels and their chemotherapeutic agents. 50,51 In this study, laser confocal microscopy and flow cytometry were employed to explore the cellular uptake of nanoparticles. As shown in Figure 4A, after the cells were incubated for 24 h with the drugs, the cytoplasmic distribution of the green fluorescence of EM in cells of the RADA16-I-EM in situ hydrogels group was significantly greater than that of free EM.…”

Section: In Vitro Cellular Uptakementioning

confidence: 99%

Antitumor Effects of Self-Assembling Peptide-Emodin in situ Hydrogels in vitro and in vivo

Wei¹,

Tang²,

Li³

et al. 2021

IJN

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“…This ink contents nanoparticles composed by melanin, monosaccharides, oligopeptides, and metals which can repolarize macrophages from pro‐tumoral (M2) to anti‐tumoral phenotype (M1) while the generated heat under NIR exposition induce ICD of tumoral cells [80] . NIR can also been employed as trigger of the production of radical oxidative species (ROS) in photodynamic therapy (PDT) to induce ICD in tumoral cells by the incorporation of certain moieties like gold nanoparticles [81] or small molecules known as photosensitizers [82] . Polydopamine nanoparticles loaded with chlorin e6 as photosensitizer have demonstrated the efficacy of the application of a combined strategy, PDT and PTT, in bladder cancer [83] …”

Section: Nanomedicines For Immune System Activation In Antitumoral Therapymentioning

confidence: 99%

Nano‐ and Microscale Drug Delivery Approaches for Therapeutic Immunomodulation

Paris

Baeza

2021

ChemNanoMat

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Nano‐ and microparticles have attracted much attention in recent years for the delivery of therapeutic molecules. Even though clinical translation for this kind of formulations has been challenging up to this point, there are some areas in which the potential for further development is immense. One of these key areas is the interaction between nano‐ and microparticles with the immune system. In this context, different characteristics of these systems can be exploited for immunomodulation. Among these key parameters, we can highlight the possibility of selectively targeting the particles towards specific cell types, as well as their capacity to co‐deliver active molecules in a controlled manner. In this way, different therapeutic strategies can be developed for a variety of pathological scenarios, either activating or inhibiting different immune responses. In this review, we provide an overview of the reported approaches based on nano‐ and microparticles to develop immune‐mediated treatments for cancer, autoimmune diseases, organ transplant and allergy.

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Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy

Cited by 141 publications

References 36 publications

Magnetic systems for cancer immunotherapy

Magnetic systems for cancer immunotherapy

Antitumor Effects of Self-Assembling Peptide-Emodin in situ Hydrogels in vitro and in vivo

Nano‐ and Microscale Drug Delivery Approaches for Therapeutic Immunomodulation

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