Magnetic Resonance Imaging Appearance of Primary Spinal Extradural Ewing’s Sarcoma: Case Report and Literature Review

Tsutsumi, Satoshi; Yasumoto, Yukimasa; Manabe, Atsushi; Ogino, Ikuko; Arai, Hajime; Ito, Masanori

doi:10.1007/s00062-013-0222-1

Cited by 14 publications

(15 citation statements)

References 11 publications

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“…Case 12 in our series is the sixth male and seventh patient in this category, and the patient is currently in good condition now. The radiographic findings of primary spinal pPNETs are usually not helpful in diagnosis and differential diagnosis, as was stated by previous studies [15,19]. Radiological diagnosis may be neurinoma, meningioma, neurofibroma, especially neurinoma.…”

Section: Radiological Featuresmentioning

confidence: 90%

“…Their study showed that there was often minimal contrast enhancement [15]. Tsutsumi et al [19] reviewed the literature and found that varying enhancement was noted. Moderate to prominent contrast enhancement were found in most of our cases.…”

Section: Radiological Featuresmentioning

confidence: 99%

“…A recent meta-analysis showed that approximately half of the primary intraspinal pPNET cases occur in the lumbar spine [16]. Tsutsumi et al [19] also reported that the thoracic spine was the most frequently affected area. In our series, 55 % (6/11) of the tumors were located at the cervical level and 27 % (3/11) at L5/S1 level, which is contrary to previous findings.…”

Section: Radiological Featuresmentioning

confidence: 99%

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Clinical presentation and long-term outcome of primary spinal peripheral primitive neuroectodermal tumors

et al. 2015

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Primary spinal peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare entities that predominantly occur in children and young adults. Few studies have reported more than three cases. There are no current optimum treatment strategies due to the paucity of data. Here, we present 13 patients (nine females and four males) with primary intraspinal pPNETs who were surgically treated from April 2008 to February 2014. Histopathologic findings revealed the expression of CD99 in all cases. Limb weakness was the most common initial symptom (11/13, 85 %). The tumors were located mainly at the cervical level (6/13, 46 %) and in the epidural space (10/13, 77 %). The radiological diagnosis was neurinoma or meningioma in most cases (10/13, 77 %). Gross total resection was achieved in 77 % (10/13) of patients. During a mean follow-up of 25.5 months, local relapse occurred in 8 (61.5 %) patients and distant metastases occurred in 8 (61.5 %) patients. The overall 1-year survival rate was 77 % (10/13), and the overall 2-year survival rate was 54 % (7/13). The 2-year survival rate was 57.1 % in patients with adjuvant chemotherapy and 50 % in those without chemotherapy. Gross total resection and adjuvant radiotherapy with or without chemotherapy demonstrated a longer survival period (1-year survival rate: 100 %; 2-year survival rate: 86 %). Our data showed that primary spinal pPNETs are extremely rare and aggressive tumors with a poor prognosis. Radical resection is advocated. Gross total resection combined with adjuvant radiation may help to significantly improve patient survival period. Chemotherapy may also help to slightly prolong patient life.

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Section: Radiological Featuresmentioning

confidence: 90%

Section: Radiological Featuresmentioning

confidence: 99%

Section: Radiological Featuresmentioning

confidence: 99%

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Clinical presentation and long-term outcome of primary spinal peripheral primitive neuroectodermal tumors

et al. 2015

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“…27 Most common site of occurrence is thoracic followed by cervical and lumbar spines. 43 The main clinical presentation is back pain, but up to 60% of patients have neurological defi cit. MRI is the diagnostic imaging study of choice.…”

Section: Primary Malignant Extradural Spinal Tumors Ewing's Sarcomamentioning

confidence: 99%

“…MRI is the diagnostic imaging study of choice. 43 Best treatment is aggressive surgical resection followed by radiation and chemotherapy. 27,40 The local control approaches 100% and long term survival is 86%.…”

Section: Primary Malignant Extradural Spinal Tumors Ewing's Sarcomamentioning

confidence: 99%

Extradural Spinal Tumors: Report of 36 Cases and Review of Literature

et al. 2016

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About 55% of spinal tumors are extradural arising from vertebral bodies, epidural and surrounding neural and soft tissues. More than 90% of extradural spinal tumors are metastatic lesions. Extradural spinal tumors are common cause of back pain, sensory motor deficit and sphincters dysfunction. The wide range of lesions and varied clinical profile, make management of spinal extradural tumors a challenging task for any neurosurgeon.Aim of this study is to analyze and discuss the results of extradural spinal tumors after surgical treatment and relevant literature will be reviewed.This is a retrospective study of 36 patients who were operated for spinal extradural tumors between May 1999 and December 2012 in our institute.Follow up period ranged from 3 years to 12 years. Functional neurological outcome was assessed by McCormick's grading. There were 20 male and 16 female and age ranged from 10 to 80 years. 30 patients presented with back pain and 15 had radicular pain. On presentation 18 patients had motor sensory deficit and 15 had sphincters dysfunction. Most common involved level of spines were thoracic followed by cervical and lumbar.Gross total excision of masses were carried out in all cases. Common pathologies were neurofibromas (16), Ewing's sarcoma (7), granulomas (3), metastatic lesions (2), angiolipoma (2), chondroma (2), aneurysmal bone cyst (1), plasmacytoma (1), rabdomyosarcoma (1) and neuroblastoma (1).Out of 14 patients who harbored malignant pathology 12 patients received radio and chemotherapy. Post operative wound infection occurred in 5 patients. Regarding post operative neurological status, 18 patients showed improvement, 6 patients remained same and 12 patients had deteriorated neurology. Tumor recurrence occurred in 15 patients; 12 patients with malignant and 3 patients with benign lesions on follow up period. There was no surgery related mortality, however, 11 patients died during 3 years follow up period due to adverse pathology they were having.Nepal Journal of Neuroscience 13:3-10, 2016

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Freiburg Neuropathology Case Conference

et al. 2018

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Magnetic Resonance Imaging Appearance of Primary Spinal Extradural Ewing’s Sarcoma: Case Report and Literature Review

Abstract: The MR imaging appearance of PSEESs is indistinguishable from other tumors. PSEES should be assumed as the differential diagnosis of spinal extradural tumors in pediatric, adolescent, and young adult patients, and prompt surgical exploration should be performed.

Cited by 14 publications

References 11 publications

Clinical presentation and long-term outcome of primary spinal peripheral primitive neuroectodermal tumors

Clinical presentation and long-term outcome of primary spinal peripheral primitive neuroectodermal tumors

Extradural Spinal Tumors: Report of 36 Cases and Review of Literature

Freiburg Neuropathology Case Conference

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