Magnetic resonance imaging for prostate cancer: Comparative studies including radical prostatectomy specimens and template transperineal biopsy

Toner, Liam; Weerakoon, Mahesha; Bolton, Damien; Ryan, Andrew; Katelaris, Nikolas; Lawrentschuk, Nathan

doi:10.1016/j.prnil.2015.09.006

Cited by 14 publications

(8 citation statements)

References 46 publications

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“…Utilizing this technique with 12–18 cores is less time‐consuming, less costly and involves a reduced general anaesthesia time for the patient when compared with techniques aforementioned . Whilst access to specialist and radiology services is improving in Australian regional centres, there is a recognized discrepancy between Medicare‐funded services, health workforce and individual health status between rural and metropolitan areas …”

Section: Discussionmentioning

confidence: 99%

“…There is ongoing debate about the reference standard to which mpMRI is compared. 34 A systematic review found that ‘various authors advocate comparing MRI with transrectal biopsy, TPB or prostatectomy specimens’ but concluded that even studies which compared both biopsy and RP specimens to MRI produced similar results, a high negative predictive value of MRI specimens …”

Section: Discussionmentioning

confidence: 99%

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Accuracy of multiparametric magnetic resonance imaging to detect significant prostate cancer and index lesion location

Goldman

Singh

Harding

et al. 2018

ANZ Journal of Surgery

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Background: Multiparametric magnetic resonance imaging (mpMRI) of the prostate appears to improve prostate cancer detection, but studies comparing mpMRI to histopathology at the time of radical prostatectomy (RP) are lacking. This retrospective study determined the accuracy of mpMRI predicting Gleason score and index lesion location at the time of RP, the current gold standard for diagnosis. Methods: Between April 2013 and April 2016, a database of all men aged more than 40 years who underwent RP after positive transrectal ultrasound biopsy by an experienced urological surgeon was collated at a single regional centre. This was cross-referenced with a database of all men who had mpMRIs performed at a single centre and reported according to Prostate Imaging Reporting and Data System (PI-RADS version 1) during this period to generate a sample size of 64 men. A Spearman's rho test was utilized to calculate correlation. Results: Median age of patients was 64 years, the median prostate-specific antigen at RP was 6.22 ng/mL. mpMRI was positive (≥PI-RADS 3) in 85.9% of patients who underwent RP. More than 92% of participants had Gleason ≥7 disease. A positive relationship between mpMRI prostate PI-RADS score and RP cancer volume was demonstrated. An anatomical location correlation calculated in octants was found to be 89.1% accurate. Conclusion: mpMRI accurately detects prostate cancer location and severity when compared with gold standard histopathology at the time of RP. It thus has an important role in planning for future prostate biopsy and cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Accuracy of multiparametric magnetic resonance imaging to detect significant prostate cancer and index lesion location

Goldman

Singh

Harding

et al. 2018

ANZ Journal of Surgery

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“…The fact that the PI-RADS criteria were updated 3 years ago further accentuates the difficulty with standardizing radiologic interpretation of prostate MRI. Other authors have emphasized that it is difficult to differentiate between the individual impact of urologists, radiologists, and institutions on detection of PCa [23,24].…”

Section: Discussionmentioning

confidence: 99%

Institutional Adoption and Apprenticeship of Fusion Targeted Prostate Biopsy: Does Experience Affect the Cancer Detection Rate?

et al. 2020

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Introduction: There are limited data on the learning curve of magnetic resonance imaging/transrectal ultrasound (MRI/ TRUS)-fusion targeted prostate biopsies (tBx). Objective: The aim of this study was to investigate the difference in prostate cancer (PCa) detection rate between an experienced urologist and novice resident performing tBx. Methods: A total of 183 patients underwent tBx from 2012 to 2016 for a total of 518 tBx cores. Biopsies in this study were performed by an experienced urologist (investigator A) or a novice resident (investigator B). The outcome was the detection of PCa on tBx. Using a multivariable logistic regression model, we estimated odds ratios for the detection of PCa. Inverse probability treatment weighting (IPTW) was used to balance patients' baseline characteristics and compare detection rates of PCa. Before performance of tBx, all patients underwent MRI. Results: On multivariable logistic regression analysis, investigator experience was associated with a higher odds of detection of PCa (OR = 1.003; 95% confidence interval 1.002-1.006, p = 0.037). After IPTW adjustment, there was no significant difference between the detection rate of investigator A (23%) and investigator B (32%; p = 0.457). Conclusions: Data revealed a positive association between investigator experience and the odds of PCa detection, although there was no difference in the detection rates of the investigators.

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“…Currently MRI-targeted biopsy has been reported to be useful in detection of evasive anterior tumors15. A review of current literature supporting utility of multi-parametric MRI (mpMRI) showed the sensitivity of mpMRI for PCa detection to be 80–90% and the specificity for suspicious lesion to be between 50% and 90%16. Despite a growing body of literature, debate over capability of mpMRI in reliably detecting significant cancer still remains17.…”

Section: Discussionmentioning

confidence: 99%

Intraprostatic locations of tumor foci of higher grade missed by diagnostic prostate biopsy among potential candidates for active surveillance

Kim

Lee

Choe

et al. 2016

Sci Rep

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To establish optimal biopsy scheme for selection of candidates for active surveillance (AS) among prostate cancer (PCa) patients, information on topographical distribution of tumor foci of higher grade missed by contemporary biopsy amongst potential candidates of AS would certainly be useful. Thus we analyzed topographic distribution of tumor foci by examining prostatectomy specimens in 444 patients who underwent radical prostatectomy for low risk PCa. Anterior and posterior prostate areas were demarcated by a horizontal line drawn at midpoint of prostatic urethra. Among 444 subjects, patients with upgrading showed relatively higher prevalence of index tumor foci in anterior prostate than those without upgrading, though not reaching statistical significance (p = 0.252). Meanwhile, among 135 (30.4%) patients with very low risk PCa, patients with upgrading showed significantly higher prevalence of index tumor foci in anterior prostate than those without upgrading (52.2% vs 33.8%; p = 0.031). In conclusions, tumor foci of higher grade missed by diagnostic biopsy were mostly located in anterior prostate among very low risk PCa patients. Such finding would be concrete evidence to support the notion that more efforts are needed to increase accuracy in detecting tumor foci in anterior prostate among potential candidates for AS.

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Magnetic resonance imaging for prostate cancer: Comparative studies including radical prostatectomy specimens and template transperineal biopsy

Cited by 14 publications

References 46 publications

Accuracy of multiparametric magnetic resonance imaging to detect significant prostate cancer and index lesion location

Accuracy of multiparametric magnetic resonance imaging to detect significant prostate cancer and index lesion location

Institutional Adoption and Apprenticeship of Fusion Targeted Prostate Biopsy: Does Experience Affect the Cancer Detection Rate?

Intraprostatic locations of tumor foci of higher grade missed by diagnostic prostate biopsy among potential candidates for active surveillance

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