Magnetic Resonance Imaging in Comparison to Clinical Palpation in Assessing the Response of Breast Cancer to Epirubicin Primary Chemotherapy

Bodini, Maria; Berruti, Alfredo; Bottini, Alberto; Allevi, Giovanni; Fiorentino, Carla; Brizzi, Maria Pia; Bersiga, Alessandra; Generali, Daniele; Volpi, D; Marini, Ugo; Aguggini, Sergio; Tampellini, Marco; Alquati, P; Olivetti, Lucio; Dogliotti, Luigi

doi:10.1023/b:brea.0000025409.69516.23

Cited by 31 publications

(22 citation statements)

References 28 publications

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“…Nineteen studies were eligible for inclusion in the systematic review (Weatherall et al , 2001; Balu-Maestro et al , 2002; Partridge et al , 2002; Rosen et al , 2003; Bodini et al , 2004; Chen et al , 2004; Londero et al , 2004; Julius et al , 2005; Montemurro et al , Yeh et al , 2005; Akazawa et al , 2006; Bollet et al , 2007; Segara et al , 2007; Bhattacharyya et al , 2008; Moon et al , 2009; Prati et al , 2009; Nakahara et al , 2010; Wright et al , 2010; Guarneri et al , 2011), reporting data on 958 patients undergoing MRI and/or comparator tests; MRI data were reported for 953 patients. Studies enrolled patients between 1998 and 2007 (median mid-point of recruitment 2002), and included a median of 38 patients with MRI data (range 12–195).…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen studies (Weatherall et al , 2001; Partridge et al , 2002; Rosen et al , 2003; Bodini et al , 2004; Chen et al , 2004; Londero et al , 2004; Montemurro et al , 2005; Akazawa et al , 2006; Bollet et al , 2007; Segara et al , 2007; Bhattacharyya et al , 2008; Moon et al , 2009; Prati et al , 2009; Nakahara et al , 2010; Wright et al , 2010; Guarneri et al , 2011) reported correlations between MRI and pathologic tumour size, and similar correlations for at least one alternative test, either by the Pearson's ( N =9) or Spearman's ( N =5) method (in two studies (Weatherall et al , 2001; Partridge et al , 2002), the method was not specified). The range of correlation coefficients was wide (0.21–0.92), with a median value of 0.70 (Supplementary Informtion Resource 4).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies reported correlations with pathology of MRI and mammography (Weatherall et al , 2001; Bodini et al , 2004; Londero et al , 2004; Bollet et al , 2007; Prati et al , 2009; Wright et al , 2010), all of which reported consistently higher correlation coefficients for MRI. However, of the 10 studies that reported correlations with pathology of MRI and clinical examination (Weatherall et al , 2001; Partridge et al , 2002; Rosen et al , 2003; Bodini et al , 2004; Chen et al , 2004; Akazawa et al , 2006; Bollet et al , 2007; Segara et al , 2007; Prati et al , 2009; Wright et al , 2010), two found correlations favouring the latter test (Prati et al , 2009; Wright et al , 2010).…”

Section: Resultsmentioning

confidence: 99%

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Meta-analysis of agreement between MRI and pathologic breast tumour size after neoadjuvant chemotherapy

et al. 2013

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Background:Magnetic resonance imaging (MRI) has been proposed to guide breast cancer surgery by measuring residual tumour after neoadjuvant chemotherapy. This study-level meta-analysis examines MRI's agreement with pathology, compares MRI with alternative tests and investigates consistency between different measures of agreement.Methods:A systematic literature search was undertaken. Mean differences (MDs) in tumour size between MRI or comparator tests and pathology were pooled by assuming a fixed effect. Limits of agreement (LOA) were estimated from a pooled variance by assuming equal variance of the differences across studies.Results:Data were extracted from 19 studies (958 patients). The pooled MD between MRI and pathology from six studies was 0.1 cm (95% LOA: −4.2 to 4.4 cm). Similar overestimation for MRI (MD: 0.1 cm) and ultrasound (US) (MD: 0.1 cm) was observed, with comparable LOA (two studies). Overestimation was lower for MRI (MD: 0.1 cm) than mammography (MD: 0.4 cm; two studies). Overestimation by MRI (MD: 0.1 cm) was smaller than underestimation by clinical examination (MD: −0.3 cm). The LOA for mammography and clinical examination were wider than that for MRI. Percentage agreement between MRI and pathology was greater than that of comparator tests (six studies). The range of Pearson's/Spearman's correlations was wide (0.21–0.92; 16 studies). Inconsistencies between MDs, percentage agreement and correlations were common.Conclusion:Magnetic resonance imaging appears to slightly overestimate pathologic size, but measurement errors may be large enough to be clinically significant. Comparable performance by US was observed, but agreement with pathology was poorer for mammography and clinical examination. Percentage agreement can provide supplementary information to MDs and LOA, but Pearson's/Spearman's correlation does not provide evidence of agreement and should be avoided. Further comparisons of MRI and other tests using the recommended methods are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Meta-analysis of agreement between MRI and pathologic breast tumour size after neoadjuvant chemotherapy

et al. 2013

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“…[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] The authors cite a number of studies demonstrating the value of MRI in this arena of imaging. MRI has been shown to be more sensitive and more specific (in certain studies) than other imaging modalities, and has been shown to more accurately correlate with post surgical pathology.…”

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confidence: 99%

Current Role of Magnetic Resonance Imaging in Breast Imaging: A Primer for the Primary Care Physician

Shah¹,

Shah²,

Greatrex³

2005

The Journal of the American Board of Family Medicine

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Magnetic resonance imaging (MRI) isMagnetic resonance imaging (MRI) has revolutionized many areas of body imaging. As a noninvasive, nonirradiating imaging tool, interest has steadily been developing as to the specific role of MRI in breast imaging, and whether this modality can assist with early detection and hopefully subsequently decrease the mortality of breast cancer.Mammography has long been used for early detection of and screening for breast cancers. With optimal technique and patient conditions, it has a reported sensitivity between 69% and 90% and a specificity between 10% and 40%. Many factors, including density of breast tissue (ie, younger patients, implants, and post surgical state) can affect these values. Ultrasound has been used as an adjunct to mammography, with particular value in differentiating cystic from solid lesions and in facilitating guided biopsy of suspicious areas. However, ultrasound has limitations, including the possibility of missing microcalcifications [associated with ductal carcinoma in situ (DCIS)] and difficulty in ensuring that the entire breast was imaged with the transducer.

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“…Although some aspects of palpation can improve with training, 7,8 palpation has been shown to be problematic in the detection of cancer, [9][10][11][12] assessment of joint laxity, 13 determination of fetal position 14 , glaucoma, 15 and in assessing circulatory disorders 3,16 As a specific form of palpation, manual assessment of tissue stiffness fares no better. Judgments made by experienced manipulative physical therapists were found to have poor reliability 17 and tended to underestimate the magnitude of applied force and overestimate tissue motion.…”

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confidence: 99%

The Accuracy of Ultrasonic Indentation in Detecting Simulated Bone Displacement: A Comparison of Three Techniques

Kawchuk

Liddle

Fauvel

et al. 2006

Journal of Manipulative and Physiological Therapeutics

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Magnetic Resonance Imaging in Comparison to Clinical Palpation in Assessing the Response of Breast Cancer to Epirubicin Primary Chemotherapy

Cited by 31 publications

References 28 publications

Meta-analysis of agreement between MRI and pathologic breast tumour size after neoadjuvant chemotherapy

Meta-analysis of agreement between MRI and pathologic breast tumour size after neoadjuvant chemotherapy

Current Role of Magnetic Resonance Imaging in Breast Imaging: A Primer for the Primary Care Physician

The Accuracy of Ultrasonic Indentation in Detecting Simulated Bone Displacement: A Comparison of Three Techniques

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