Magnetic Resonance Imaging Technique for Visualization of Irregular Cerebrospinal Fluid Motion in the Ventricular System and Subarachnoid Space

Horie, Tomohiko; Kajihara, Nao; Matsumae, Mitsunori; Obara, Makoto; Hayashi, Naokazu; Hirayama, Akihiro; Takizawa, Ken; Takahara, Taro; Yatsushiro, Satoshi; Kuroda, Kagayaki

doi:10.1016/j.wneu.2016.07.062

Cited by 36 publications

(51 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Horie et al 3) presented the Dynamic iMSDE SSFP method that visualizes random CSF motion in a short duration. This method is excellent for capturing turbulence.…”

Section: Discussionmentioning

confidence: 99%

“…Up till now, it has been used for carotid artery walls, 6,7) aneurysms, 8) blood vessels of the lower limbs, 9,10) brain metastasis detection, 11,12) and visualization of peripheral nerves (MR neurography). 13,14) On the other hand, until the report by Horie et al, 3) there were no reports that applied iMSDE to observe CSF dynamics. However, actively inducing dephasing using MSG is feasible in CSF similar to blood, and we reported this usefulness in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Please refer to the cited literature for details on the magnetic resonance imaging (MRI) sequence. 3)…”

Section: Patientsmentioning

confidence: 99%

“…Furthermore, we could also capture the recovery of CSF motion through fenestration of the intraventricular cyst wall. In addition, focusing on the imaging time, the commonly reported PC method requires 2-3 min (dependent on pulse), 3) and the Time-SLIP method requires approximately 4 min, 25) whereas the Dynamic iMSDE SSFP only takes 30 s, 3) indicating that the short imaging time is an advantage especially for pediatric patients or at outpatient clinics. Moreover, the Dynamic iMSDE SSFP method can achieve asynchronous images, which do not require triggers such as electrocardiogram or peripheral pulse waveform required by the PC method, indicating that the settings are simple and that fluctuation in the imaging time that relies on a trigger is minimal.…”

Section: Fig 3 Left: a 13-year-old Female Who Presented With Obstrucmentioning

confidence: 99%

“…In addition to accelerating and becoming turbulent like this in certain spaces, it is also known that when, for example, the movement of water molecules propagates through a narrow stoma between two cavities, water molecules move more aggressively at this time, and when fluid propagates to another cavity, it becomes turbulent. 3) In the case of endoscopic third ventriculostomy (ETV), the fenestration of the third ventricle floor corresponds to such stoma, and neurosurgeons equalize the CSF motion between the third ventricle and the subarachnoid space of the ventral surface of the brainstem through this stoma, thereby improving hydrocephalus. To achieve this, neurosurgeons must determine the turbulence at the fenestration after ETV by evaluating images of the stoma patency.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Simple Identification of Cerebrospinal Fluid Turbulent Motion Using a Dynamic Improved Motion-sensitized Driven-equilibrium Steady-state Free Precession Method Applied to Various Types of Cerebrospinal Fluid Motion Disturbance

Aoki

Horie

Kajihara

et al. 2020

Neurol. Med. Chir.(Tokyo)

Self Cite

View full text Add to dashboard Cite

The motion of cerebrospinal fluid (CSF) within the subarachnoid space and ventricles is greatly modulated when propagating synchronously with the cardiac pulse and respiratory cycle and path through the nerves, blood vessels, and arachnoid trabeculae. Water molecule movement that propagates between two spaces via a stoma, foramen, or duct presents increased acceleration when passing through a narrow area and can exhibit "turbulence." Recently, neurosurgeons have started to perform fenestration procedures using neuroendoscopy to treat hydrocephalus and cystic lesions. As part of the postoperative evaluation, a noninvasive diagnostic technique to visualize the water molecules at the fenestrated site is necessary. Because turbulence is observed at this fenestrated site, an imaging technique appropriate for observing this turbulence is essential. We therefore investigated the usefulness of a dynamic improved motion-sensitized driven-equilibrium steady-state free precession (Dynamic iMSDE SSFP) sequence of magnetic resonance imaging that is superior for ascertaining turbulent motions in healthy volunteers and patients. Images of Dynamic iMSDE SSFP from volunteers revealed that CSF motion at the ventral surface of the brainstem and the third ventricle is augmented and turbulent. Moreover, our findings confirmed that this technique is useful for evaluating treatments that utilize neuroendoscopy. As a result, Dynamic iMSDE SSFP, a simple sequence for visualizing CSF motion, entails a short imaging time, can extensively visualize CSF motion, does not require additional processes such as labeling or trigger setting, and is anticipated to have wide-ranging clinical applications in the future.

show abstract

“…Horie et al 3) presented the Dynamic iMSDE SSFP method that visualizes random CSF motion in a short duration. This method is excellent for capturing turbulence.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Please refer to the cited literature for details on the magnetic resonance imaging (MRI) sequence. 3)…”

Section: Patientsmentioning

confidence: 99%

Section: Fig 3 Left: a 13-year-old Female Who Presented With Obstrucmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Simple Identification of Cerebrospinal Fluid Turbulent Motion Using a Dynamic Improved Motion-sensitized Driven-equilibrium Steady-state Free Precession Method Applied to Various Types of Cerebrospinal Fluid Motion Disturbance

Aoki

Horie

Kajihara

et al. 2020

Neurol. Med. Chir.(Tokyo)

Self Cite

View full text Add to dashboard Cite

show abstract

Enlarged Perivascular Spaces in Infancy and Autism Diagnosis, Cerebrospinal Fluid Volume, and Later Sleep Problems

Garic,

McKinstry,

Rutsohn

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

ImportancePerivascular spaces (PVS) and cerebrospinal fluid (CSF) are essential components of the glymphatic system, regulating brain homeostasis and clearing neural waste throughout the lifespan. Enlarged PVS have been implicated in neurological disorders and sleep problems in adults, and excessive CSF volume has been reported in infants who develop autism. Enlarged PVS have not been sufficiently studied longitudinally in infancy or in relation to autism outcomes or CSF volume.ObjectiveTo examine whether enlarged PVS are more prevalent in infants who develop autism compared with controls and whether they are associated with trajectories of extra-axial CSF volume (EA-CSF) and sleep problems in later childhood.Design, Setting, and ParticipantsThis prospective, longitudinal cohort study used data from the Infant Brain Imaging Study. Magnetic resonance images were acquired at ages 6, 12, and 24 months (2007-2017), with sleep questionnaires performed between ages 7 and 12 years (starting in 2018). Data were collected at 4 sites in North Carolina, Missouri, Pennsylvania, and Washington. Data were analyzed from March 2021 through August 2022.ExposurePVS (ie, fluid-filled channels that surround blood vessels in the brain) that are enlarged (ie, visible on magnetic resonance imaging).Main Outcomes and MeasuresOutcomes of interest were enlarged PVS and EA-CSF volume from 6 to 24 months, autism diagnosis at 24 months, sleep problems between ages 7 and 12 years.ResultsA total of 311 infants (197 [63.3%] male) were included: 47 infants at high familial likelihood for autism (ie, having an older sibling with autism) who were diagnosed with autism at age 24 months, 180 high likelihood infants not diagnosed with autism, and 84 low likelihood control infants not diagnosed with autism. Sleep measures at school-age were available for 109 participants. Of infants who developed autism, 21 (44.7%) had enlarged PVS at 24 months compared with 48 infants (26.7%) in the high likelihood but no autism diagnosis group (P = .02) and 22 infants in the control group (26.2%) (P = .03). Across all groups, enlarged PVS at 24 months was associated with greater EA-CSF volume from ages 6 to 24 months (β = 4.64; 95% CI, 0.58-8.72; P = .002) and more frequent night wakings at school-age (F = 7.76; η2 = 0.08; P = .006).Conclusions and RelevanceThese findings suggest that enlarged PVS emerged between ages 12 and 24 months in infants who developed autism. These results add to a growing body of evidence that, along with excessive CSF volume and sleep dysfunction, the glymphatic system could be dysregulated in infants who develop autism.

show abstract

Visualization of cerebrospinal fluid dynamics using multi‐spin echo acquisition cine imaging (MUSACI)

Wada

Tokunaga

Togao

et al. 2018

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

Magnetic Resonance Imaging Technique for Visualization of Irregular Cerebrospinal Fluid Motion in the Ventricular System and Subarachnoid Space

Cited by 36 publications

References 27 publications

Simple Identification of Cerebrospinal Fluid Turbulent Motion Using a Dynamic Improved Motion-sensitized Driven-equilibrium Steady-state Free Precession Method Applied to Various Types of Cerebrospinal Fluid Motion Disturbance

Simple Identification of Cerebrospinal Fluid Turbulent Motion Using a Dynamic Improved Motion-sensitized Driven-equilibrium Steady-state Free Precession Method Applied to Various Types of Cerebrospinal Fluid Motion Disturbance

Enlarged Perivascular Spaces in Infancy and Autism Diagnosis, Cerebrospinal Fluid Volume, and Later Sleep Problems

Visualization of cerebrospinal fluid dynamics using multi‐spin echo acquisition cine imaging (MUSACI)

Contact Info

Product

Resources

About