Magnetic resonance imaging to identify risk of lymph node metastasis in patients with endometrial cancer

Undurraga, Manuela; Petignat, Patrick; Pelte, Marie‐Françoise; Jacob, S.; Dubuisson, Jean‐Bernard; Loubeyre, Pierre

doi:10.1016/j.ijgo.2008.10.021

Cited by 27 publications

(23 citation statements)

References 18 publications

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“…4) [13,39]. This study evaluated the diagnostic performance of MRI using standard final surgical staging and lymph node evaluation by a pathologist as reference standard.…”

Section: Discussionmentioning

confidence: 99%

“…Ideally, MRI should identify deep myometrial invasion (invasion of ≥50% of the myometrial wall), cervical stroma invasion and extent of local or regional tumour spread, including metastasis to lymph nodes [7][8][9]. However, the reported accuracy of MRI in the detection of these findings varies considerably, even in the recent literature [10][11][12][13][14]. This may be due to the different MRI protocols applied as well as interobserver variability in the interpretation of the diagnostic images.…”

Section: Introductionmentioning

confidence: 99%

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Standard 1.5-T MRI of endometrial carcinomas: modest agreement between radiologists

et al. 2012

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“…4) [13,39]. This study evaluated the diagnostic performance of MRI using standard final surgical staging and lymph node evaluation by a pathologist as reference standard.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Standard 1.5-T MRI of endometrial carcinomas: modest agreement between radiologists

et al. 2012

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“…Cystoscopy, proctoscopy and intravenous urography are only indicated in case of abnormality on MRI. This technique allows studying the myometrial invasion degree with a sensitivity and specificity in the literature varying between 50 and 64% and between 70 and 89% respectively [32][33][34][35] and appreciating the cervical and lymph node invasion [35]. However, physical examination under general anesthesia remains interesting in the clinical evaluation of tumor extension [36], especially for these obese patients who do not let themselves to be examined easily.…”

Section: Obesity Through Androgens Conversion To Estrogens In Adipocytesmentioning

confidence: 99%

The endometrial cancer in Southern Tunisia: Investigation about 52 cases

Kebaïli¹,

K²,

Louati³

et al. 2015

Integr Cancer Sci Therap

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To study the epidemiological, clinical, paraclinical and therapeutic caracteristics of this cancer in south Tunisia population, a retrospective descriptive and analytic study was conducted over a period of 12 years from January 1993 until December 2004 on 52 patients carrying endometrial cancer. Diagnosis and therapeutic management were made in the departments of Obstetrics and Gynecology University Hospital HediChaker of Sfax and radiotherapy at the University Hospital Habib Bourguiba of Sfax. The average age of patients was 57.53 years. Menopause was observed in 76.92% cases. Hypertension, obesity and diabetes were observed, respectively, in 40.38%, 26.92% and 11.53% of cases. The mean delay of consulting was 8 months. Uterine bleeding was observed in 98.07% cases. Endometrial b iopsy curettage or directed biopsy was performed in 50 women (96.15%) including 35 women under hysteroscopy. Histopathological examination was conclusive in 46 patients (92%) Adenocarcinoma was the most frequent histological type found in 39 cases (84.78%). Physical examination under general anesthesia was carried out for 44 patients it was normal in 77.27% of cases. The magnetic resonance imaging was performed in 3 patients. Stage I and II were the most observed stages. Preoperative brachytherapy was achieved only in 30 women. Surgery was indicated in 49 cases (94.23%). Thirty three patients (63.46%) received supplemental external radiotherapy. Overall survival at 5 years was 66.8%. Endometrial cancer in associated with many risk factors it must be evoked in front of any abnormal bleeding in aged women. Endometrial biopsy curettage performed under hysteroscopy allows the diagnosis in most cases. Magnetic resonance imaging allows tumorstaging. Treatment is based on the triade brachytherapy, surgery and external post operative radiotherapy. Chemotherapyis added in the therapeutic arsenal in high recidive risk tumor.

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“…For diagnosis of deep myometrial infiltration, cervical invasion, or both, MRI sensitivity and specificity were 56% and 85%; 47% and 83%; and 67% and 77%, respectively. However MRI has limited value in identifying patients with endometrial carcinoma who are at risk of lymph node metastasis [31]. …”

Section: Diagnostic Approachmentioning

confidence: 99%

Controversies in the Management of Endometrial Carcinoma

Zhang

Wang

2010

Obstetrics and Gynecology International

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Endometrial carcinoma is the most common type of female genital tract malignancy. Although endometrial carcinoma is a low grade curable malignancy, the condition of the disease can range from excellent prognosis with high curability to aggressive disease with poor outcome. During the last 10 years many researches have provided some new valuable data of optimal treatments for endometrial carcinoma. Progression in diagnostic imaging, radiation delivery systems, and systemic therapies potentially can improve outcomes while minimizing morbidity. Firstly, total hysterectomy and bilateral salphingo-oophorectomy is the primary operative procedure. Pelvic lymhadenectomy is performed in most centers on therapeutic and prognostic grounds and to individualize adjuvant treatment. Women with endometrial carcinoma can be readily segregated intraoperatively into “low-risk” and “high-risk” groups to better identify those women who will most likely benefit from thorough lymphadenectomy. Secondly, adjuvant therapies have been proposed for women with endometrial carcinoma postoperatively. Postoperative irradiation is used to reduce pelvic and vaginal recurrences in high risk cases. Chemotherapy is emerging as an important treatment modality in advanced endometrial carcinoma. Meanwhile the availability of new hormonal and biological agents presents new opportunities for therapy.

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Magnetic resonance imaging to identify risk of lymph node metastasis in patients with endometrial cancer

Abstract: MRI has limited value in identifying patients with endometrial cancer who are at risk of lymph node metastasis. Minimally invasive laparoscopic lymph node staging should be undertaken when it is feasible.

Cited by 27 publications

References 18 publications

Standard 1.5-T MRI of endometrial carcinomas: modest agreement between radiologists

Standard 1.5-T MRI of endometrial carcinomas: modest agreement between radiologists

The endometrial cancer in Southern Tunisia: Investigation about 52 cases

Controversies in the Management of Endometrial Carcinoma

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